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Heparin-induced thrombocytopenia

MedGen UID:
124423
Concept ID:
C0272285
Disease or Syndrome
Synonyms: HAT; Heparin Induced Thrombocytopenia; Heparin induced thrombocytopenia; Heparin-associated thrombocytopenia; Heparin-Induced Thrombocytopenia; Heparin-induced thrombocytopenia type 2; HIT
Modes of inheritance:
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
not inherited (Orphanet)
SNOMED CT: Heparin-induced thrombocytopenia (73397007); Heparin induced thrombocytopenia (73397007)
 
HPO: HP:0011874
Orphanet: ORPHA3325

Definition

Low platelet count following administration of unfractionated or (less commonly) low-molecular weight heparin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeparin-induced thrombocytopenia
Follow this link to review classifications for Heparin-induced thrombocytopenia in Orphanet.

Recent clinical studies

Etiology

Itabashi R, Yazawa Y, Kawata K, Shigehatake Y, Yang S, Otomo K, Furui E
J Stroke Cerebrovasc Dis 2015 Aug;24(8):e219-21. Epub 2015 May 14 doi: 10.1016/j.jstrokecerebrovasdis.2015.04.021. PMID: 25980337
Pericleous A, Sadek M, Fitzmaurice M, Caldwell C, Natividad K, Plestis KA
Tex Heart Inst J 2014 Dec 1;41(6):645-8. doi: 10.14503/THIJ-13-3631. PMID: 25593533Free PMC Article
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576
Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators.; Canadian Critical Care Trials Group.; Australian and New Zealand Intensive Care Society Clinical Trials Group.
J Crit Care 2014 Jun;29(3):470.e7-15. Epub 2014 Feb 14 doi: 10.1016/j.jcrc.2014.02.004. PMID: 24726205
Benken ST, Tillman N, Dajani S, Shah A, Thomas T
J Cardiothorac Surg 2014 Mar 21;9:55. doi: 10.1186/1749-8090-9-55. PMID: 24656312Free PMC Article

Diagnosis

Itabashi R, Yazawa Y, Kawata K, Shigehatake Y, Yang S, Otomo K, Furui E
J Stroke Cerebrovasc Dis 2015 Aug;24(8):e219-21. Epub 2015 May 14 doi: 10.1016/j.jstrokecerebrovasdis.2015.04.021. PMID: 25980337
Pericleous A, Sadek M, Fitzmaurice M, Caldwell C, Natividad K, Plestis KA
Tex Heart Inst J 2014 Dec 1;41(6):645-8. doi: 10.14503/THIJ-13-3631. PMID: 25593533Free PMC Article
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576
Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators.; Canadian Critical Care Trials Group.; Australian and New Zealand Intensive Care Society Clinical Trials Group.
J Crit Care 2014 Jun;29(3):470.e7-15. Epub 2014 Feb 14 doi: 10.1016/j.jcrc.2014.02.004. PMID: 24726205
Seigerman M, Cavallaro P, Itagaki S, Chung I, Chikwe J
J Cardiothorac Vasc Anesth 2014 Feb;28(1):98-102. Epub 2013 Dec 2 doi: 10.1053/j.jvca.2013.07.021. PMID: 24295719

Therapy

Yuan SM
Pak J Pharm Sci 2015 Sep;28(5):1793-6. PMID: 26408899
Itabashi R, Yazawa Y, Kawata K, Shigehatake Y, Yang S, Otomo K, Furui E
J Stroke Cerebrovasc Dis 2015 Aug;24(8):e219-21. Epub 2015 May 14 doi: 10.1016/j.jstrokecerebrovasdis.2015.04.021. PMID: 25980337
Miyares MA, Davis KA
Ann Pharmacother 2015 Jun;49(6):735-9. Epub 2015 Apr 8 doi: 10.1177/1060028015579424. PMID: 25855702
Vianello F, Furian L, Nordio M, Treleani M, Fabris F
Hematology 2015 Jan;20(1):48-9. Epub 2014 Feb 28 doi: 10.1179/1607845414Y.0000000157. PMID: 24580134
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576

Prognosis

Samuelson BT, Glynn E, Holmes M, White AA, Martin DB, Garcia D
Thromb Res 2015 Nov;136(5):928-31. Epub 2015 Sep 8 doi: 10.1016/j.thromres.2015.09.005. PMID: 26384443
Miyares MA, Davis KA
Ann Pharmacother 2015 Jun;49(6):735-9. Epub 2015 Apr 8 doi: 10.1177/1060028015579424. PMID: 25855702
Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators.; Canadian Critical Care Trials Group.; Australian and New Zealand Intensive Care Society Clinical Trials Group.
J Crit Care 2014 Jun;29(3):470.e7-15. Epub 2014 Feb 14 doi: 10.1016/j.jcrc.2014.02.004. PMID: 24726205
Benken ST, Tillman N, Dajani S, Shah A, Thomas T
J Cardiothorac Surg 2014 Mar 21;9:55. doi: 10.1186/1749-8090-9-55. PMID: 24656312Free PMC Article
Seigerman M, Cavallaro P, Itagaki S, Chung I, Chikwe J
J Cardiothorac Vasc Anesth 2014 Feb;28(1):98-102. Epub 2013 Dec 2 doi: 10.1053/j.jvca.2013.07.021. PMID: 24295719

Clinical prediction guides

Samuelson BT, Glynn E, Holmes M, White AA, Martin DB, Garcia D
Thromb Res 2015 Nov;136(5):928-31. Epub 2015 Sep 8 doi: 10.1016/j.thromres.2015.09.005. PMID: 26384443
Miyares MA, Davis KA
Ann Pharmacother 2015 Jun;49(6):735-9. Epub 2015 Apr 8 doi: 10.1177/1060028015579424. PMID: 25855702
Chen YC, Lin CY, Tsai CS
J Formos Med Assoc 2015 Oct;114(10):981-7. Epub 2013 Dec 12 doi: 10.1016/j.jfma.2013.11.003. PMID: 24331583
Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators.; Canadian Critical Care Trials Group.; Australian and New Zealand Intensive Care Society Clinical Trials Group.
J Crit Care 2014 Jun;29(3):470.e7-15. Epub 2014 Feb 14 doi: 10.1016/j.jcrc.2014.02.004. PMID: 24726205
Seigerman M, Cavallaro P, Itagaki S, Chung I, Chikwe J
J Cardiothorac Vasc Anesth 2014 Feb;28(1):98-102. Epub 2013 Dec 2 doi: 10.1053/j.jvca.2013.07.021. PMID: 24295719

Recent systematic reviews

Snodgrass MN, Shields J, Rai H
Clin Appl Thromb Hemost 2016 Nov;22(8):712-717. Epub 2016 May 13 doi: 10.1177/1076029616646873. PMID: 27179015
Miyares MA, Davis KA
Ann Pharmacother 2015 Jun;49(6):735-9. Epub 2015 Apr 8 doi: 10.1177/1060028015579424. PMID: 25855702
Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators.; Canadian Critical Care Trials Group.; Australian and New Zealand Intensive Care Society Clinical Trials Group.
J Crit Care 2014 Jun;29(3):470.e7-15. Epub 2014 Feb 14 doi: 10.1016/j.jcrc.2014.02.004. PMID: 24726205
Bhatt VR, Aryal MR, Shrestha R, Armitage JO
Eur J Haematol 2013 Nov;91(5):437-41. Epub 2013 Aug 20 doi: 10.1111/ejh.12179. PMID: 23905719
Rosenberger LH, Smith PW, Sawyer RG, Hanks JB, Adams RB, Hedrick TL
Crit Care Med 2011 Apr;39(4):833-8. doi: 10.1097/CCM.0b013e318206d0eb. PMID: 21242799Free PMC Article

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