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Alkaloid

MedGen UID:
7968
Concept ID:
C0002062
Organic Chemical; Pharmacologic Substance
Synonyms: Alkaloids
SNOMED CT: Alkaloid (419001004)
 

Definition

A family or group of nitrogen-containing base compounds primarily derived from plant and animal sources. Many alkaloids are used medicinally, including cancer therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlkaloid

Recent clinical studies

Etiology

Huang G, Drakopoulos A, Saedtler M, Zou H, Meinel L, Heilmann J, Decker M
Bioorg Med Chem Lett 2017 Nov 1;27(21):4937-4941. Epub 2017 Aug 24 doi: 10.1016/j.bmcl.2017.08.045. PMID: 28958621
Zhang H, Loveridge ST, Tenney K, Crews P
Nat Prod Res 2016 Jun;30(11):1262-5. Epub 2015 Jul 13 doi: 10.1080/14786419.2015.1054826. PMID: 26165203Free PMC Article
Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY
Drug Des Devel Ther 2015;9:4861-8. Epub 2015 Aug 25 doi: 10.2147/DDDT.S87858. PMID: 26346783Free PMC Article
da Silva G, Martinho A, Soengas RG, Duarte AP, Serrano R, Gomes ET, Silva O
Fitoterapia 2015 Oct;106:7-11. Epub 2015 Aug 1 doi: 10.1016/j.fitote.2015.07.020. PMID: 26241493
Armenian P, Kearney TE
Clin Toxicol (Phila) 2014 Mar;52(3):214-9. Epub 2014 Feb 16 doi: 10.3109/15563650.2014.885037. PMID: 24528175

Diagnosis

Galadari S, Rahman A, Pallichankandy S, Thayyullathil F
Phytomedicine 2017 Oct 15;34:143-153. Epub 2017 Aug 8 doi: 10.1016/j.phymed.2017.08.006. PMID: 28899497
Stegelmeier BL, Colegate SM, Brown AW
Toxins (Basel) 2016 Nov 29;8(12) doi: 10.3390/toxins8120356. PMID: 27916846Free PMC Article
Mohan V, Agarwal R, Singh RP
Biochem Biophys Res Commun 2016 Sep 2;477(4):1065-1071. Epub 2016 Jul 9 doi: 10.1016/j.bbrc.2016.07.037. PMID: 27402273
Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY
Drug Des Devel Ther 2015;9:4861-8. Epub 2015 Aug 25 doi: 10.2147/DDDT.S87858. PMID: 26346783Free PMC Article
Patel K, Gadewar M, Tripathi R, Prasad SK, Patel DK
Asian Pac J Trop Biomed 2012 Aug;2(8):660-4. doi: 10.1016/S2221-1691(12)60116-6. PMID: 23569990Free PMC Article

Therapy

Suhaimi FW, Yusoff NH, Hassan R, Mansor SM, Navaratnam V, Müller CP, Hassan Z
Brain Res Bull 2016 Sep;126(Pt 1):29-40. Epub 2016 Mar 25 doi: 10.1016/j.brainresbull.2016.03.015. PMID: 27018165
Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY
Drug Des Devel Ther 2015;9:4861-8. Epub 2015 Aug 25 doi: 10.2147/DDDT.S87858. PMID: 26346783Free PMC Article
Cavalcante-Silva LH, Falcão MA, Vieira AC, Viana MD, de Araújo-Júnior JX, Sousa JC, da Silva TM, Barbosa-Filho JM, Noël F, de Miranda GE, Santos BV, Alexandre-Moreira MS
Molecules 2014 Sep 16;19(9):14699-709. doi: 10.3390/molecules190914699. PMID: 25230124
Kaiser S, Dietrich F, de Resende PE, Verza SG, Moraes RC, Morrone FB, Batastini AM, Ortega GG
Planta Med 2013 Oct;79(15):1413-20. Epub 2013 Aug 23 doi: 10.1055/s-0033-1350742. PMID: 23975868
Fernandes LM, Garcez WS, Mantovani MS, Figueiredo PO, Fernandes CA, Garcez FR, Guterres ZR
Food Chem Toxicol 2013 Sep;59:405-11. Epub 2013 Jun 20 doi: 10.1016/j.fct.2013.05.052. PMID: 23793037

Prognosis

Stegelmeier BL, Colegate SM, Brown AW
Toxins (Basel) 2016 Nov 29;8(12) doi: 10.3390/toxins8120356. PMID: 27916846Free PMC Article
Jähne EA, Eigenmann DE, Sampath C, Butterweck V, Culot M, Cecchelli R, Gosselet F, Walter FR, Deli MA, Smieško M, Hamburger M, Oufir M
Planta Med 2016 Jul;82(11-12):1021-9. Epub 2016 Apr 19 doi: 10.1055/s-0042-105295. PMID: 27093249
Dyshlovoy SA, Venz S, Hauschild J, Tabakmakher KM, Otte K, Madanchi R, Walther R, Guzii AG, Makarieva TN, Shubina LK, Fedorov SN, Stonik VA, Bokemeyer C, Balabanov S, Honecker F, V Amsberg G
Proteomics 2016 May;16(10):1590-603. Epub 2016 Apr 27 doi: 10.1002/pmic.201500334. PMID: 27001414
Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY
Drug Des Devel Ther 2015;9:4861-8. Epub 2015 Aug 25 doi: 10.2147/DDDT.S87858. PMID: 26346783Free PMC Article
Cortes N, Alvarez R, Osorio EH, Alzate F, Berkov S, Osorio E
J Pharm Biomed Anal 2015 Jan;102:222-8. Epub 2014 Sep 28 doi: 10.1016/j.jpba.2014.09.022. PMID: 25305596

Clinical prediction guides

Ismail A, Noolu B, Gogulothu R, Perugu S, Rajanna A, Babu SK
J Med Food 2016 Dec;19(12):1155-1165. doi: 10.1089/jmf.2016.3767. PMID: 27982755
Wang XD, Li CY, Jiang MM, Li D, Wen P, Song X, Chen JD, Guo LX, Hu XP, Li GQ, Zhang J, Wang CH, He ZD
Phytomedicine 2016 Jun 1;23(6):641-53. Epub 2016 Mar 24 doi: 10.1016/j.phymed.2016.03.003. PMID: 27161405
Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY
Drug Des Devel Ther 2015;9:4861-8. Epub 2015 Aug 25 doi: 10.2147/DDDT.S87858. PMID: 26346783Free PMC Article
Jin H, Chen L, Tian Y, Li B, Dong JX
J Asian Nat Prod Res 2015;17(1):33-9. Epub 2014 Nov 4 doi: 10.1080/10286020.2014.968560. PMID: 25367562
Kaiser S, Dietrich F, de Resende PE, Verza SG, Moraes RC, Morrone FB, Batastini AM, Ortega GG
Planta Med 2013 Oct;79(15):1413-20. Epub 2013 Aug 23 doi: 10.1055/s-0033-1350742. PMID: 23975868

Recent systematic reviews

Dos Santos RG, Hallak JE
J Psychoactive Drugs 2017 Jan-Mar;49(1):1-10. Epub 2016 Dec 5 doi: 10.1080/02791072.2016.1260189. PMID: 27918874
Chan TY
Phytother Res 2015 Aug;29(8):1107-11. Epub 2015 May 14 doi: 10.1002/ptr.5370. PMID: 25974837
Ng JS
J Oncol Pharm Pract 2011 Sep;17(3):209-24. Epub 2010 Jun 28 doi: 10.1177/1078155210373525. PMID: 20584744
Douillard JY, Laporte S, Fossella F, Georgoulias V, Pujol JL, Kubota K, Monnier A, Kudoh S, Rubio JE, Cucherat M
J Thorac Oncol 2007 Oct;2(10):939-46. doi: 10.1097/JTO.0b013e318153fa2b. PMID: 17909357
Hughes JR, Williams JG, Currier RD
J Am Geriatr Soc 1976 Nov;24(11):490-7. PMID: 823192

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