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Chromosome 11;14 translocation

MedGen UID:
441047
•Concept ID:
CN072184
•
Disease or Syndrome

Professional guidelines

PubMed

Mantle cell lymphoma: 2013 Update on diagnosis, risk-stratification, and clinical management.
Vose JM
Am J Hematol 2013 Dec;88(12):1082-8. doi: 10.1002/ajh.23615. PMID: 24273091
Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management.
Vose JM
Am J Hematol 2012 Jun;87(6):604-9. doi: 10.1002/ajh.23176. PMID: 22615102
Current treatment standards and emerging strategies in mantle cell lymphoma.
Dreyling M, Hiddemann W; European MCL Network
Hematology Am Soc Hematol Educ Program 2009:542-51. doi: 10.1182/asheducation-2009.1.542. PMID: 20008239

Recent clinical studies

Etiology

11q23/MLL rearrangements in adult acute leukemia.
Zotova OV, Lukianova AS, Valchuk MO, Karol YS, Shalay OO, Novak VL, Loginsky VE
Exp Oncol 2021 Sep;43(3):229-233. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-3.16495. PMID: 34591430
Phase I Study of Venetoclax Plus Daratumumab and Dexamethasone, With or Without Bortezomib, in Patients With Relapsed or Refractory Multiple Myeloma With and Without t(11;14).
Bahlis NJ, Baz R, Harrison SJ, Quach H, Ho SJ, Vangsted AJ, Plesner T, Moreau P, Gibbs SD, Coppola S, Yang X, Al Masud A, Ross JA, Bueno O, Kaufman JL
J Clin Oncol 2021 Nov 10;39(32):3602-3612. Epub 2021 Aug 13 doi: 10.1200/JCO.21.00443. PMID: 34388020Free PMC Article
Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma.
Kaufman JL, Gasparetto C, Schjesvold FH, Moreau P, Touzeau C, Facon T, Boise LH, Jiang Y, Yang X, Dunbar F, Vishwamitra D, Unger S, Macartney T, Pesko J, Yu Y, Salem AH, Ross JA, Hong WJ, Maciag PC, Pauff JM, Kumar S
Am J Hematol 2021 Apr 1;96(4):418-427. Epub 2021 Jan 19 doi: 10.1002/ajh.26083. PMID: 33368455Free PMC Article
Immunophenotypic and laboratory features of t(11;14)(q13;q32)-positive plasma cell neoplasms.
Shi M, Ternus JA, Ketterling RP, Jevremovic D, McPhail ED
Leuk Lymphoma 2018 Aug;59(8):1913-1919. Epub 2017 Dec 7 doi: 10.1080/10428194.2017.1410885. PMID: 29214874
Translocation t(11;14) in newly diagnosed patients with multiple myeloma: Is it always favorable?
Leiba M, Duek A, Amariglio N, Avigdor A, Benyamini N, Hardan I, Zilbershats I, Ganzel C, Shevetz O, Novikov I, Cohen Y, Ishoev G, Rozic G, Nagler A, Trakhtenbrot L
Genes Chromosomes Cancer 2016 Sep;55(9):710-8. Epub 2016 Jun 24 doi: 10.1002/gcc.22372. PMID: 27152944

Diagnosis

11q23/MLL rearrangements in adult acute leukemia.
Zotova OV, Lukianova AS, Valchuk MO, Karol YS, Shalay OO, Novak VL, Loginsky VE
Exp Oncol 2021 Sep;43(3):229-233. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-3.16495. PMID: 34591430
Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.
Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT
Cancer Med 2021 Jun;10(12):3839-3847. Epub 2021 May 27 doi: 10.1002/cam4.3904. PMID: 34042280Free PMC Article
Translocation (11;14) in newly diagnosed multiple myeloma, time to reclassify this standard risk chromosomal aberration?
Gran C, Uttervall K, Borg Bruchfeld J, Wallblom A, Alici E, Gahrton G, Nahi H
Eur J Haematol 2019 Dec;103(6):588-596. Epub 2019 Oct 6 doi: 10.1111/ejh.13325. PMID: 31487754
Immunophenotypic and laboratory features of t(11;14)(q13;q32)-positive plasma cell neoplasms.
Shi M, Ternus JA, Ketterling RP, Jevremovic D, McPhail ED
Leuk Lymphoma 2018 Aug;59(8):1913-1919. Epub 2017 Dec 7 doi: 10.1080/10428194.2017.1410885. PMID: 29214874
Translocation t(11;14) in newly diagnosed patients with multiple myeloma: Is it always favorable?
Leiba M, Duek A, Amariglio N, Avigdor A, Benyamini N, Hardan I, Zilbershats I, Ganzel C, Shevetz O, Novikov I, Cohen Y, Ishoev G, Rozic G, Nagler A, Trakhtenbrot L
Genes Chromosomes Cancer 2016 Sep;55(9):710-8. Epub 2016 Jun 24 doi: 10.1002/gcc.22372. PMID: 27152944

Therapy

Phase I Study of Venetoclax Plus Daratumumab and Dexamethasone, With or Without Bortezomib, in Patients With Relapsed or Refractory Multiple Myeloma With and Without t(11;14).
Bahlis NJ, Baz R, Harrison SJ, Quach H, Ho SJ, Vangsted AJ, Plesner T, Moreau P, Gibbs SD, Coppola S, Yang X, Al Masud A, Ross JA, Bueno O, Kaufman JL
J Clin Oncol 2021 Nov 10;39(32):3602-3612. Epub 2021 Aug 13 doi: 10.1200/JCO.21.00443. PMID: 34388020Free PMC Article
Multiple myeloma with t(11;14)-associated immature phenotype has lower CD38 expression and higher BCL2 dependence.
Kitadate A, Terao T, Narita K, Ikeda S, Takahashi Y, Tsushima T, Miura D, Takeuchi M, Takahashi N, Matsue K
Cancer Sci 2021 Sep;112(9):3645-3654. Epub 2021 Jul 29 doi: 10.1111/cas.15073. PMID: 34288263Free PMC Article
Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.
Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT
Cancer Med 2021 Jun;10(12):3839-3847. Epub 2021 May 27 doi: 10.1002/cam4.3904. PMID: 34042280Free PMC Article
Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma.
Kaufman JL, Gasparetto C, Schjesvold FH, Moreau P, Touzeau C, Facon T, Boise LH, Jiang Y, Yang X, Dunbar F, Vishwamitra D, Unger S, Macartney T, Pesko J, Yu Y, Salem AH, Ross JA, Hong WJ, Maciag PC, Pauff JM, Kumar S
Am J Hematol 2021 Apr 1;96(4):418-427. Epub 2021 Jan 19 doi: 10.1002/ajh.26083. PMID: 33368455Free PMC Article
Translocation (11;14) in newly diagnosed multiple myeloma, time to reclassify this standard risk chromosomal aberration?
Gran C, Uttervall K, Borg Bruchfeld J, Wallblom A, Alici E, Gahrton G, Nahi H
Eur J Haematol 2019 Dec;103(6):588-596. Epub 2019 Oct 6 doi: 10.1111/ejh.13325. PMID: 31487754

Prognosis

11q23/MLL rearrangements in adult acute leukemia.
Zotova OV, Lukianova AS, Valchuk MO, Karol YS, Shalay OO, Novak VL, Loginsky VE
Exp Oncol 2021 Sep;43(3):229-233. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-3.16495. PMID: 34591430
Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.
Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT
Cancer Med 2021 Jun;10(12):3839-3847. Epub 2021 May 27 doi: 10.1002/cam4.3904. PMID: 34042280Free PMC Article
Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma.
Kaufman JL, Gasparetto C, Schjesvold FH, Moreau P, Touzeau C, Facon T, Boise LH, Jiang Y, Yang X, Dunbar F, Vishwamitra D, Unger S, Macartney T, Pesko J, Yu Y, Salem AH, Ross JA, Hong WJ, Maciag PC, Pauff JM, Kumar S
Am J Hematol 2021 Apr 1;96(4):418-427. Epub 2021 Jan 19 doi: 10.1002/ajh.26083. PMID: 33368455Free PMC Article
Translocation t(11;14) in newly diagnosed patients with multiple myeloma: Is it always favorable?
Leiba M, Duek A, Amariglio N, Avigdor A, Benyamini N, Hardan I, Zilbershats I, Ganzel C, Shevetz O, Novikov I, Cohen Y, Ishoev G, Rozic G, Nagler A, Trakhtenbrot L
Genes Chromosomes Cancer 2016 Sep;55(9):710-8. Epub 2016 Jun 24 doi: 10.1002/gcc.22372. PMID: 27152944
Mantle cell lymphoma.
Bertoni F, Zucca E, Cavalli F
Curr Opin Hematol 2004 Nov;11(6):411-8. doi: 10.1097/01.moh.0000138682.13354.da. PMID: 15548996

Clinical prediction guides

Phase I Study of Venetoclax Plus Daratumumab and Dexamethasone, With or Without Bortezomib, in Patients With Relapsed or Refractory Multiple Myeloma With and Without t(11;14).
Bahlis NJ, Baz R, Harrison SJ, Quach H, Ho SJ, Vangsted AJ, Plesner T, Moreau P, Gibbs SD, Coppola S, Yang X, Al Masud A, Ross JA, Bueno O, Kaufman JL
J Clin Oncol 2021 Nov 10;39(32):3602-3612. Epub 2021 Aug 13 doi: 10.1200/JCO.21.00443. PMID: 34388020Free PMC Article
Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.
Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT
Cancer Med 2021 Jun;10(12):3839-3847. Epub 2021 May 27 doi: 10.1002/cam4.3904. PMID: 34042280Free PMC Article
Translocation (11;14) in newly diagnosed multiple myeloma, time to reclassify this standard risk chromosomal aberration?
Gran C, Uttervall K, Borg Bruchfeld J, Wallblom A, Alici E, Gahrton G, Nahi H
Eur J Haematol 2019 Dec;103(6):588-596. Epub 2019 Oct 6 doi: 10.1111/ejh.13325. PMID: 31487754
Clinical Implications of t(11;14) in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation.
Takamatsu H, Yamashita T, Kurahashi S, Saitoh T, Kondo T, Maeda T, Nakazawa H, Murata M, Narita T, Kuroda J, Hashimoto H, Kawamura K, Miyamoto T, Honda S, Ichinohe T, Atsuta Y, Sunami K
Biol Blood Marrow Transplant 2019 Mar;25(3):474-479. Epub 2018 Nov 10 doi: 10.1016/j.bbmt.2018.11.003. PMID: 30423479
t(11;14)(q23;q32) involving IGH and DDX6 in nodal marginal zone lymphoma.
Stary S, Vinatzer U, Müllauer L, Raderer M, Birner P, Streubel B
Genes Chromosomes Cancer 2013 Jan;52(1):33-43. Epub 2012 Sep 11 doi: 10.1002/gcc.22004. PMID: 22965301

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