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Items: 1 to 20 of 21

1.

Fluorouracil

An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. [from NCI]

MedGen UID:
5229
Concept ID:
C0016360
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
2.

Accumulation

An increase of substance (e.g., proteinaceous fluid and glycogen) in either the intracellular space, extracellular space, or within a hollow organ or structure. [from NCI_CDISC]

MedGen UID:
883922
Concept ID:
C4055506
Finding
3.

5-[18F]Fluorouracil

The fluorine-18 (18F)-radiolabeled pyrimidine analog 5-fluorouracil (5-FU) with positron-emitting activity. Upon administration, 5-[18F]fluorouracil distribution in tumor tissue may be measured with positron emission tomography (PET). The degree of 5-[18F]fluorouracil uptake in tumor tissue may help to predict the response to 5-fluorouracil-based chemotherapy or to determine the response to other therapeutic agents used to treat 5-FU-sensitive tumors. [from NCI]

MedGen UID:
398465
Concept ID:
C2700356
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
4.

Haploinsufficiency

A copy number variation that results in reduced GENE DOSAGE due to any loss-of-function mutation. The loss of heterozygosity is associated with abnormal phenotypes or diseased states because the remaining gene is insufficient. [from MeSH]

MedGen UID:
424691
Concept ID:
C2936267
Cell or Molecular Dysfunction
5.

Antimetabolites

A drug that is very similar to natural chemicals in a normal biochemical reaction in cells but different enough to interfere with the normal division and functions of cells. [from NCI_NCI-GLOSS]

MedGen UID:
8136
Concept ID:
C0003376
Pharmacologic Substance
6.

Onkofluor

MedGen UID:
297394
Concept ID:
C1564851
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
7.

Neofluor

MedGen UID:
289931
Concept ID:
C1564850
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
8.

Haemato-fu

MedGen UID:
289930
Concept ID:
C1564849
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
9.

5-Fluorouracil-biosyn

MedGen UID:
289928
Concept ID:
C1564842
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
10.

Fluorouracil-GRY

MedGen UID:
289059
Concept ID:
C1564846
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
11.

Ribofluor

MedGen UID:
274518
Concept ID:
C1517232
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
12.

Fluracedyl

MedGen UID:
274517
Concept ID:
C1517230
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
13.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
14.

Polyadenylation

The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here. [from MeSH]

MedGen UID:
215435
Concept ID:
C0949765
Molecular Function
15.

Carac

MedGen UID:
215257
Concept ID:
C0939777
Organic Chemical; Pharmacologic Substance
16.

Fluoroplex

MedGen UID:
195881
Concept ID:
C0699375
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
17.

Efudex

MedGen UID:
195880
Concept ID:
C0699372
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
18.

Adrucil

MedGen UID:
152035
Concept ID:
C0699374
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
19.

Sequence Deletion

Deletion of sequences of nucleic acids from the genetic material of an individual. [from MeSH]

MedGen UID:
102460
Concept ID:
C0162773
Cell or Molecular Dysfunction
20.

Mutagenesis Process

Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS. [from MeSH]

MedGen UID:
86969
Concept ID:
C0079866
Molecular Function
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