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Items: 17

1.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
2.

Methionine preparation

A sulfur-containing essential L-amino acid that is important in many body functions. [from MeSH]

MedGen UID:
9989
Concept ID:
C0025646
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
3.

Decreasing

MedGen UID:
617794
Concept ID:
C0442797
Finding
4.

Amino acid

Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
5.

Growth substance

Signal molecules that are involved in the control of cell growth and differentiation. [from MeSH]

MedGen UID:
315661
Concept ID:
C1812630
Biologically Active Substance; Pharmacologic Substance
6.

Angiogenesis Modulating Agents

Agents that modulate the PHYSIOLOGIC ANGIOGENESIS process. This is accomplished by endogenous ANGIOGENIC PROTEINS and a variety of other chemicals and pharmaceutical agents. [from MeSH]

MedGen UID:
263447
Concept ID:
C1257849
Pharmacologic Substance
7.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
8.

Magnesiocard

MedGen UID:
195605
Concept ID:
C0677518
Amino Acid, Peptide, or Protein; Pharmacologic Substance
9.

Angiogenesis inhibitor

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. [from MeSH]

MedGen UID:
154540
Concept ID:
C0596087
Biologically Active Substance; Pharmacologic Substance
10.

Mutagenesis

Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS. [from MeSH]

MedGen UID:
86969
Concept ID:
C0079866
Molecular Function
11.

Growth Inhibitors

Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS). [from MeSH]

MedGen UID:
42306
Concept ID:
C0018282
Biologically Active Substance; Pharmacologic Substance
12.

Protein binding

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. [from MeSH]

MedGen UID:
18704
Concept ID:
C0033618
Molecular Function
13.

Mg-5-Longoral

MedGen UID:
9851
Concept ID:
C0024470
Amino Acid, Peptide, or Protein; Pharmacologic Substance
14.

Enzyme inhibitor

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from MeSH]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance
15.

Enzyme stability

The extent to which an enzyme retains its structural conformation or its activity when subjected to storage, isolation, and purification or various other physical or chemical manipulations, including proteolytic enzymes and heat. [from MeSH]

MedGen UID:
4976
Concept ID:
C0014439
Molecular Function
16.

Antineoplastic agent

A substance that inhibits the maturation, growth or spread of tumor cells. [from NCI]

MedGen UID:
1984
Concept ID:
C0003392
Organic Chemical; Pharmacologic Substance
17.

MetAP2 Inhibitor SDX-7320

A synthetic copolymer-drug conjugate of a fumagillin-derived methionine aminopeptidase 2 (MetAP2) inhibitor conjugated to the bio-compatible polymer poly(N-(hydroxypropyl)methacrylamide) (HPMA), with potential antineoplastic activity. Upon administration of SDX-7320, the active moiety SDX7539 is released inside the tumor cells. SDX7539 binds to and inhibits MetAP2, which prevents MetAP2-mediated signal transduction pathways and results in tumor cell death. MetAP2, a member of the dimetallohydrolase family upregulated in certain tumor cell types, plays a key role in angiogenesis, proliferation and survival. Polymer conjugation reduces systemic drug exposure and increases this agent's efficacy as compared to non-polymer conjugates. [from NCI]

MedGen UID:
925243
Concept ID:
C4287711
Organic Chemical; Pharmacologic Substance
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