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Items: 10

1.

Pravastatin

A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04) [from NCI]

MedGen UID:
88434
Concept ID:
C0085542
Organic Chemical; Pharmacologic Substance
2.

Fosinopril

A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow. [from NCI]

MedGen UID:
49641
Concept ID:
C0118168
Organic Chemical; Pharmacologic Substance
3.

Microalbuminuria

MedGen UID:
896933
Concept ID:
C1654921
Finding
4.

Microalbuminuria

The presence of mildly increased concentrations of albumin in the urine (in adults, 30-150 mg per day). [from HPO]

MedGen UID:
676540
Concept ID:
C0730345
Finding
5.

Fozitec

MedGen UID:
292624
Concept ID:
C1567475
Organic Chemical; Pharmacologic Substance
6.

Hiperlex

MedGen UID:
291354
Concept ID:
C1567479
Amino Acid, Peptide, or Protein; Pharmacologic Substance
7.

Dynacil

MedGen UID:
291352
Concept ID:
C1567477
Organic Chemical; Pharmacologic Substance
8.

Fosinil

MedGen UID:
291351
Concept ID:
C1567476
Organic Chemical; Pharmacologic Substance
9.

Newace

MedGen UID:
147524
Concept ID:
C0728957
Amino Acid, Peptide, or Protein; Pharmacologic Substance
10.

SQ-28,555

MedGen UID:
107769
Concept ID:
C0543474
Amino Acid, Peptide, or Protein; Pharmacologic Substance
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