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Items: 15

1.

Proguanil hydrochloride

The hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite. [from NCI]

MedGen UID:
107476
Concept ID:
C0546856
Organic Chemical; Pharmacologic Substance
2.

Atovaquone

A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. [from MeSH]

MedGen UID:
58474
Concept ID:
C0165603
Organic Chemical; Pharmacologic Substance
3.

Chloroguanide

A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent. [from MeSH]

MedGen UID:
40250
Concept ID:
C0008241
Organic Chemical; Pharmacologic Substance
4.

Quinine

A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) [from NCI]

MedGen UID:
11086
Concept ID:
C0034417
Organic Chemical; Pharmacologic Substance
5.

Disease due to Plasmodiidae

A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia. [from MeSH]

MedGen UID:
7443
Concept ID:
C0024530
Disease or Syndrome
6.

Severe

Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
104640
Concept ID:
C0205082
Qualitative Concept
7.

Falciparum malaria

Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations. [from MeSH]

MedGen UID:
6185
Concept ID:
C0024535
Disease or Syndrome
8.

Wellvone

MedGen UID:
902313
Concept ID:
C4082282
Organic Chemical; Pharmacologic Substance
9.

Bigumal

MedGen UID:
208623
Concept ID:
C0795708
Organic Chemical; Pharmacologic Substance
10.

566C80

MedGen UID:
196061
Concept ID:
C0700939
Organic Chemical; Pharmacologic Substance
11.

Chloriguane

MedGen UID:
162859
Concept ID:
C0795709
Organic Chemical; Pharmacologic Substance
12.

Mepron

MedGen UID:
138397
Concept ID:
C0378468
Organic Chemical; Pharmacologic Substance
13.

566C

MedGen UID:
104005
Concept ID:
C0165602
Organic Chemical; Pharmacologic Substance
14.

Paludrine

MedGen UID:
79380
Concept ID:
C0282100
Organic Chemical; Pharmacologic Substance
15.

Atovaquone + Proguanil

MedGen UID:
182635
Concept ID:
C0939219
Pharmacologic Substance
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