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Items: 12

1.

human leukocyte interferon

A biological response modifier (a substance that can improve the body's natural response to infection and disease). Interferons interfere with the division of cancer cells and can slow tumor growth. There are several types of interferons, including interferon-alpha, -beta, and -gamma. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases. [from NCI]

MedGen UID:
196514
Concept ID:
C0733470
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
2.

Interferon

Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. [from MeSH]

MedGen UID:
5847
Concept ID:
C0021747
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
3.

Vesicular stomatitis

A viral disease caused by at least two distinct species (serotypes) in the VESICULOVIRUS genus: VESICULAR STOMATITIS INDIANA VIRUS and VESICULAR STOMATITIS NEW JERSEY VIRUS. It is characterized by vesicular eruptions on the ORAL MUCOSA in cattle, horses, pigs, and other animals. In humans, vesicular stomatitis causes an acute influenza-like illness. [from MeSH]

MedGen UID:
75624
Concept ID:
C0266999
Disease or Syndrome
4.

oligoadenylate

MedGen UID:
54014
Concept ID:
C0133819
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
5.

Stomatitis

Stomatitis is an inflammation of the mucous membranes of any of the structures in the mouth. [from HPO]

MedGen UID:
52511
Concept ID:
C0038362
Disease or Syndrome
6.

Superimposed infection

A frequent complication of drug therapy for microbial infection. It may result from opportunistic colonization following immunosuppression by the primary pathogen and can be influenced by the time interval between infections, microbial physiology, or host resistance. Experimental challenge and in vitro models are sometimes used in virulence and infectivity studies. [from MeSH]

MedGen UID:
11659
Concept ID:
C0038826
Disease or Syndrome
7.

Able

MedGen UID:
721424
Concept ID:
C1299581
Finding
8.

Stomatitis

Stomatitis is an inflammation of the mucous membranes of any of the structures in the mouth. [from HPO]

MedGen UID:
508414
Concept ID:
C0149704
Disease or Syndrome
9.

metaplastic cell transformation

In medicine, the change that a normal cell undergoes as it becomes malignant. [from NCI]

MedGen UID:
266929
Concept ID:
C1510411
Pathologic Function
10.

Anophthalmos with limb anomalies

Microphthalmia, anophthalmia, and coloboma comprise the MAC spectrum of ocular malformations. Microphthalmia refers to a globe with a total axial length that is at least two standard deviations below the mean for age. Anophthalmia refers to complete absence of the globe in the presence of ocular adnexa (eyelids, conjunctiva, and lacrimal apparatus). Coloboma refers to the ocular malformations that result from failure of closure of the optic fissure. Chorioretinal coloboma refers to coloboma of the retina and choroid. Iris coloboma causes the iris to appear keyhole-shaped. Microphthalmia, anophthalmia, and coloboma may be unilateral or bilateral; when bilateral they may occur in any combination. [from GeneReviews]

MedGen UID:
154638
Concept ID:
C0599973
Disease or Syndrome
11.

2',5'-oligoadenylate

An oligonucleotide synthesized from adenosine triphosphate (ATP) by enzymes in the 2'-5'-oligoadenylate synthase family. The production of 2'-5'-oligoadenylate is stimulated by the presence of double stranded RNA (dsRNA) and binds to inactive monomeric forms of ribonuclease L (RNase L), thereby promoting RNase L dimerization and activation. Active RNase L degrades both cellular and viral RNAs, which inhibits protein translation and leads to the abrogation of viral replication. 2'-5'-oligoadenylates play a key role in the innate immunity against viruses. [from NCI]

MedGen UID:
53415
Concept ID:
C0045143
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
12.

VP-2

MedGen UID:
57339
Concept ID:
C0148584
Organic Chemical; Pharmacologic Substance; Steroid
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