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Risedronate

MedGen UID:
67788
Concept ID:
C0246719
Organic Chemical; Pharmacologic Substance
Synonyms: 1-Hydroxy-2-(3-pyridyl)ethylidene diphosphonate; 2-(3-pyridinyl)-1-hydroxyethylidene-bisphosphonate; 2-(3-pyridinyl)-1-hydroxyethylidenebisphosphonate
SNOMED CT: Risedronate (387582001)
 

Definition

A synthetic pyridinyl bisphosphonate agent. Risedronate binds to hydroxyapatite crystals in bone and inhibits osteoclast-dependent bone resorption Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256445&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256445&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1528" NCI Thesaurus) [from PDQ]

Recent clinical studies

Etiology

Aspenberg P, Malouf J, Tarantino U, García-Hernández PA, Corradini C, Overgaard S, Stepan JJ, Borris L, Lespessailles E, Frihagen F, Papavasiliou K, Petto H, Caeiro JR, Marin F
J Bone Joint Surg Am 2016 Nov 16;98(22):1868-1878. doi: 10.2106/JBJS.15.01217. PMID: 27852903
Inoue D, Muraoka R, Okazaki R, Nishizawa Y, Sugimoto T
Calcif Tissue Int 2016 Feb;98(2):114-22. Epub 2015 Oct 14 doi: 10.1007/s00223-015-0071-9. PMID: 26466937Free PMC Article
Paliologo T, Shimano RC, Shimano AC, Macedo AP, Falcai MJ, Issa JP
Micron 2015 Nov;78:40-4. Epub 2015 Jul 10 doi: 10.1016/j.micron.2015.07.002. PMID: 26210684
Sánchez-Escuredo A, Fuster D, Rubello D, Muxí A, Ramos A, Campos F, Marzola MC, Cook GJ, Tapias A, Torregrosa JV
Nucl Med Commun 2015 Aug;36(8):815-8. doi: 10.1097/MNM.0000000000000316. PMID: 25856225
León Vázquez F, Herrero Hernández S, Cuerpo Triguero C, Andrés Prado MJ, Cabello Ballesteros L
Reumatol Clin 2015 Mar-Apr;11(2):64-7. Epub 2014 Aug 6 doi: 10.1016/j.reuma.2014.05.003. PMID: 25107345

Diagnosis

Gu JM, Wang L, Lin H, Chen DC, Tang H, Jin XL, Xia WB, Hu YQ, Fu WZ, He JW, Zhang H, Wang C, Yue H, Hu WW, Liu YJ, Zhang ZL
Acta Pharmacol Sin 2015 Jul;36(7):841-6. Epub 2015 Jun 8 doi: 10.1038/aps.2015.30. PMID: 26051110Free PMC Article
Hongo M, Miyakoshi N, Kasukawa Y, Ishikawa Y, Shimada Y
J Bone Miner Metab 2015 Jul;33(4):432-9. Epub 2014 Aug 15 doi: 10.1007/s00774-014-0603-9. PMID: 25123562
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A
Clin Schizophr Relat Psychoses 2015 Apr;9(1):36-9. doi: 10.3371/CSRP.HIGI.043013. PMID: 23644167
Seo YH, Chung YH, Lim CH, Jeong JH
J Chromatogr Sci 2014 Aug;52(7):713-8. Epub 2013 Jul 12 doi: 10.1093/chromsci/bmt105. PMID: 23851998
Ghassabian S, Wright LA, Dejager AD, Smith MT
J Chromatogr B Analyt Technol Biomed Life Sci 2012 Jan 15;881-882:34-41. Epub 2011 Nov 28 doi: 10.1016/j.jchromb.2011.11.031. PMID: 22197608

Therapy

Aspenberg P, Malouf J, Tarantino U, García-Hernández PA, Corradini C, Overgaard S, Stepan JJ, Borris L, Lespessailles E, Frihagen F, Papavasiliou K, Petto H, Caeiro JR, Marin F
J Bone Joint Surg Am 2016 Nov 16;98(22):1868-1878. doi: 10.2106/JBJS.15.01217. PMID: 27852903
Inoue D, Muraoka R, Okazaki R, Nishizawa Y, Sugimoto T
Calcif Tissue Int 2016 Feb;98(2):114-22. Epub 2015 Oct 14 doi: 10.1007/s00223-015-0071-9. PMID: 26466937Free PMC Article
Paliologo T, Shimano RC, Shimano AC, Macedo AP, Falcai MJ, Issa JP
Micron 2015 Nov;78:40-4. Epub 2015 Jul 10 doi: 10.1016/j.micron.2015.07.002. PMID: 26210684
León Vázquez F, Herrero Hernández S, Cuerpo Triguero C, Andrés Prado MJ, Cabello Ballesteros L
Reumatol Clin 2015 Mar-Apr;11(2):64-7. Epub 2014 Aug 6 doi: 10.1016/j.reuma.2014.05.003. PMID: 25107345
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A
Clin Schizophr Relat Psychoses 2015 Apr;9(1):36-9. doi: 10.3371/CSRP.HIGI.043013. PMID: 23644167

Prognosis

Gu JM, Wang L, Lin H, Chen DC, Tang H, Jin XL, Xia WB, Hu YQ, Fu WZ, He JW, Zhang H, Wang C, Yue H, Hu WW, Liu YJ, Zhang ZL
Acta Pharmacol Sin 2015 Jul;36(7):841-6. Epub 2015 Jun 8 doi: 10.1038/aps.2015.30. PMID: 26051110Free PMC Article
Muren O, Akbarian E, Salemyr M, Bodén H, Eisler T, Stark A, Sköldenberg O
Acta Orthop 2015;86(5):569-74. doi: 10.3109/17453674.2015.1041846. PMID: 25885280Free PMC Article
Benlidayi IC, Ortac EA, Kozanoglu E
Acta Clin Belg 2015 Apr;70(2):130-2. Epub 2014 Oct 22 doi: 10.1179/2295333714Y.0000000094. PMID: 25338093
Sestak I, Singh S, Cuzick J, Blake GM, Patel R, Gossiel F, Coleman R, Dowsett M, Forbes JF, Howell A, Eastell R
Lancet Oncol 2014 Dec;15(13):1460-8. Epub 2014 Nov 11 doi: 10.1016/S1470-2045(14)71035-6. PMID: 25456365
van Bodegraven AA, Bravenboer N, Witte BI, Dijkstra G, van der Woude CJ, Stokkers PC, Russel MG, Oldenburg B, Pierik M, Roos JC, van Hogezand RA, Dik VK, Oostlander AE, Netelenbos JC, van de Langerijt L, Hommes DW, Lips P; Dutch Initiative on Crohn and Colitis (ICC).
Gut 2014 Sep;63(9):1424-30. Epub 2013 Oct 21 doi: 10.1136/gutjnl-2013-305523. PMID: 24146170

Clinical prediction guides

Aspenberg P, Malouf J, Tarantino U, García-Hernández PA, Corradini C, Overgaard S, Stepan JJ, Borris L, Lespessailles E, Frihagen F, Papavasiliou K, Petto H, Caeiro JR, Marin F
J Bone Joint Surg Am 2016 Nov 16;98(22):1868-1878. doi: 10.2106/JBJS.15.01217. PMID: 27852903
Paliologo T, Shimano RC, Shimano AC, Macedo AP, Falcai MJ, Issa JP
Micron 2015 Nov;78:40-4. Epub 2015 Jul 10 doi: 10.1016/j.micron.2015.07.002. PMID: 26210684
Sánchez-Escuredo A, Fuster D, Rubello D, Muxí A, Ramos A, Campos F, Marzola MC, Cook GJ, Tapias A, Torregrosa JV
Nucl Med Commun 2015 Aug;36(8):815-8. doi: 10.1097/MNM.0000000000000316. PMID: 25856225
Hongo M, Miyakoshi N, Kasukawa Y, Ishikawa Y, Shimada Y
J Bone Miner Metab 2015 Jul;33(4):432-9. Epub 2014 Aug 15 doi: 10.1007/s00774-014-0603-9. PMID: 25123562
Hagino H, Kishimoto H, Ohishi H, Horii S, Nakamura T
Bone 2014 Feb;59:44-52. Epub 2013 Oct 29 doi: 10.1016/j.bone.2013.10.017. PMID: 24184313

Recent systematic reviews

Eiken P, Vestergaard P
Osteoporos Int 2016 Jan;27(1):1-12. Epub 2015 Oct 5 doi: 10.1007/s00198-015-3334-4. PMID: 26438307
Recker RR, Ste-Marie LG, Chavassieux P, McClung MR, Lundy MW
Osteoporos Int 2015 Jan;26(1):327-37. Epub 2014 Oct 11 doi: 10.1007/s00198-014-2850-y. PMID: 25304456
Bradbury LA, Barlow S, Geoghegan F, Hannon RA, Stuckey SL, Wass JA, Russell RG, Brown MA, Duncan EL
Osteoporos Int 2012 Jan;23(1):285-94. Epub 2011 Jul 8 doi: 10.1007/s00198-011-1658-2. PMID: 21739105
Roux C, Goldstein JL, Zhou X, Klemes A, Lindsay R
Osteoporos Int 2012 Jan;23(1):277-84. Epub 2011 Mar 2 doi: 10.1007/s00198-011-1574-5. PMID: 21365461
Boonen S, Klemes AB, Zhou X, Lindsay R
J Am Geriatr Soc 2010 Apr;58(4):658-63. Epub 2010 Mar 22 doi: 10.1111/j.1532-5415.2010.02763.x. PMID: 20345865

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