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Cytomegalovirus infection

MedGen UID:
8239
Concept ID:
C0010823
Disease or Syndrome
Synonyms: Cytomegalic Inclusion Disease; Cytomegalic Inclusion Diseases; Cytomegalovirus Infection; Cytomegalovirus Infections; Disease, Cytomegalic Inclusion; Diseases, Cytomegalic Inclusion; Inclusion Disease; Inclusion Disease, Cytomegalic; Inclusion Diseases; Inclusion Diseases, Cytomegalic; Infection, Cytomegalovirus; Infections, Cytomegalovirus; Salivary Gland Virus Disease
SNOMED CT: CMV - Cytomegalovirus infection (28944009); Disease due to Cytomegalovirus (28944009); Cytomegalovirus disease (28944009); Cytomegalovirus infection (28944009); Cytomegalic inclusion disease (28944009); Salivary gland virus disease (28944009)
 

Definition

Cytomegalovirus (CMV) is a virus found around the world. It is related to the viruses that cause chickenpox and infectious mononucleosis (mono). Between 50 percent and 80 percent of adults in the United States have had a CMV infection by age 40. Once CMV is in a person's body, it stays there for life. . CMV is spread through close contact with body fluids. Most people with CMV don't get sick and don't know that they've been infected. But infection with the virus can be serious in babies and people with weak immune systems. If a woman gets CMV when she is pregnant, she can pass it on to her baby. Usually the babies do not have health problems. But some babies can develop lifelong disabilities. A blood test can tell whether a person has ever been infected with CMV. Most people with CMV don't need treatment. If you have a weakened immune system, your doctor may prescribe antiviral medicine. Good hygiene, including proper hand washing, may help prevent infections. Centers for Disease Control and Prevention.  [from MedlinePlus]

Recent clinical studies

Etiology

Ishihara H, Ishida H, Toki D, Omoto K, Sirakawa H, Shimizu T, Okumi M, Tanabe K
Exp Clin Transplant 2015 Dec;13(6):573-80. PMID: 26643678
Afshari A, Yaghobi R, Karimi MH, Darbouy M, Azarpira N, Geramizadeh B, Malek-Hosseini SA, Nikeghbalian S
Exp Clin Transplant 2015 Apr;13 Suppl 1:83-9. PMID: 25894133
Nijman J, Mandemaker FS, Verboon-Maciolek MA, Aitken SC, van Loon AM, de Vries LS, Schuurman R
PLoS One 2014 Sep 30;9(9):e108018. doi: 10.1371/journal.pone.0108018. PMID: 25268349Free PMC Article
White AL, Hedlund GL, Bale JF Jr
Pediatr Neurol 2014 Mar;50(3):218-23. Epub 2013 Nov 16 doi: 10.1016/j.pediatrneurol.2013.11.005. PMID: 24373410
Kim YS, Kim YH, Kim JS, Cheon JH, Ye BD, Jung SA, Park YS, Choi CH, Jang BI, Han DS, Yang SK, Kim WH; IBD Study Group of the Korean Association for the Study of Intestinal Diseases.
J Clin Gastroenterol 2012 Jan;46(1):51-6. doi: 10.1097/MCG.0b013e3182160c9c. PMID: 21552140

Diagnosis

Afshari A, Yaghobi R, Karimi MH, Darbouy M, Azarpira N, Geramizadeh B, Malek-Hosseini SA, Nikeghbalian S
Exp Clin Transplant 2015 Apr;13 Suppl 1:83-9. PMID: 25894133
Nijman J, Mandemaker FS, Verboon-Maciolek MA, Aitken SC, van Loon AM, de Vries LS, Schuurman R
PLoS One 2014 Sep 30;9(9):e108018. doi: 10.1371/journal.pone.0108018. PMID: 25268349Free PMC Article
Rupp C, Herpel E, Schnitzler P, Zawierucha A, Zwickel P, Klute L, Kadmon M, Stremmel W, Gauss A
J Med Case Rep 2014 May 26;8:163. doi: 10.1186/1752-1947-8-163. PMID: 24885004Free PMC Article
White AL, Hedlund GL, Bale JF Jr
Pediatr Neurol 2014 Mar;50(3):218-23. Epub 2013 Nov 16 doi: 10.1016/j.pediatrneurol.2013.11.005. PMID: 24373410
Kalil AC, Florescu DF
Crit Care Med 2009 Aug;37(8):2350-8. doi: 10.1097/CCM.0b013e3181a3aa43. PMID: 19531944

Therapy

Ishihara H, Ishida H, Toki D, Omoto K, Sirakawa H, Shimizu T, Okumi M, Tanabe K
Exp Clin Transplant 2015 Dec;13(6):573-80. PMID: 26643678
Afshari A, Yaghobi R, Karimi MH, Darbouy M, Azarpira N, Geramizadeh B, Malek-Hosseini SA, Nikeghbalian S
Exp Clin Transplant 2015 Apr;13 Suppl 1:83-9. PMID: 25894133
Rupp C, Herpel E, Schnitzler P, Zawierucha A, Zwickel P, Klute L, Kadmon M, Stremmel W, Gauss A
J Med Case Rep 2014 May 26;8:163. doi: 10.1186/1752-1947-8-163. PMID: 24885004Free PMC Article
Kim YS, Kim YH, Kim JS, Cheon JH, Ye BD, Jung SA, Park YS, Choi CH, Jang BI, Han DS, Yang SK, Kim WH; IBD Study Group of the Korean Association for the Study of Intestinal Diseases.
J Clin Gastroenterol 2012 Jan;46(1):51-6. doi: 10.1097/MCG.0b013e3182160c9c. PMID: 21552140
Kalil AC, Florescu DF
Crit Care Med 2009 Aug;37(8):2350-8. doi: 10.1097/CCM.0b013e3181a3aa43. PMID: 19531944

Prognosis

Krakar G, Đaković I, Delin S, Bošnjak VM
J Child Neurol 2015 Jan;30(1):93-5. Epub 2014 Jan 21 doi: 10.1177/0883073813514292. PMID: 24453153
Rupp C, Herpel E, Schnitzler P, Zawierucha A, Zwickel P, Klute L, Kadmon M, Stremmel W, Gauss A
J Med Case Rep 2014 May 26;8:163. doi: 10.1186/1752-1947-8-163. PMID: 24885004Free PMC Article
El-Sayed MF, Goldfarb DM, Fulford M, Pernica JM
BMC Pediatr 2013 Sep 11;13:142. doi: 10.1186/1471-2431-13-142. PMID: 24024982Free PMC Article
Ivanov IS, Popov NT, Moshe RI, Chepisheva EV, Geneva IE, Panova MV, Karparov AA, Shmilev TI, Stefanov RS, Bosheva MN
Folia Med (Plovdiv) 2012 Oct-Dec;54(4):37-44. PMID: 23441468
Kalil AC, Florescu DF
Crit Care Med 2009 Aug;37(8):2350-8. doi: 10.1097/CCM.0b013e3181a3aa43. PMID: 19531944

Clinical prediction guides

Ishihara H, Ishida H, Toki D, Omoto K, Sirakawa H, Shimizu T, Okumi M, Tanabe K
Exp Clin Transplant 2015 Dec;13(6):573-80. PMID: 26643678
Averill LW, Kandula VV, Akyol Y, Epelman M
Semin Ultrasound CT MR 2015 Dec;36(6):476-86. Epub 2015 Apr 3 doi: 10.1053/j.sult.2015.04.001. PMID: 26614131
Amir J, Attias J, Pardo J
Clin Pediatr (Phila) 2014 May;53(5):444-8. Epub 2013 Nov 25 doi: 10.1177/0009922813510204. PMID: 24275215
Gow AJ, Firth CM, Harrison R, Starr JM, Moss P, Deary IJ
Neurobiol Aging 2013 Jul;34(7):1846-52. Epub 2013 Feb 22 doi: 10.1016/j.neurobiolaging.2013.01.011. PMID: 23434472
Kim YS, Kim YH, Kim JS, Cheon JH, Ye BD, Jung SA, Park YS, Choi CH, Jang BI, Han DS, Yang SK, Kim WH; IBD Study Group of the Korean Association for the Study of Intestinal Diseases.
J Clin Gastroenterol 2012 Jan;46(1):51-6. doi: 10.1097/MCG.0b013e3182160c9c. PMID: 21552140

Recent systematic reviews

Ellington SR, Clarke KE, Kourtis AP
J Infect Dis 2016 Mar 15;213(6):891-900. Epub 2015 Nov 23 doi: 10.1093/infdis/jiv549. PMID: 26597258
Wu XW, Wu L, Ji HZ, Wang FY
Dig Dis Sci 2015 Nov;60(11):3203-8. Epub 2015 Jun 2 doi: 10.1007/s10620-015-3733-6. PMID: 26031424Free PMC Article
Britt W
Med Microbiol Immunol 2015 Jun;204(3):263-71. Epub 2015 Mar 13 doi: 10.1007/s00430-015-0399-9. PMID: 25764180
Marinho-Dias J, Sousa H
Acta Med Port 2013 Mar-Apr;26(2):154-60. Epub 2013 May 31 PMID: 23809748
Kalil AC, Florescu DF
Crit Care Med 2009 Aug;37(8):2350-8. doi: 10.1097/CCM.0b013e3181a3aa43. PMID: 19531944

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