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Items: 5

1.

Isoniazid

A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. (NCI04) [from NCI]

MedGen UID:
43975
Concept ID:
C0022209
Organic Chemical; Pharmacologic Substance
2.

Cytochrome P-450 CYP2E1 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2E1. [from MeSH]

MedGen UID:
827151
Concept ID:
C3850057
Pharmacologic Substance
3.

Parafon

MedGen UID:
327845
Concept ID:
C1564758
Organic Chemical; Pharmacologic Substance
4.

Paraflex

MedGen UID:
208828
Concept ID:
C0813433
Organic Chemical; Pharmacologic Substance
5.

Chlorzoxozone

A benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities. Although its exact mechanism of action is unknown, chlorzoxazone (CZ) appears to act at the spinal cord and subcortical levels of the brain to inhibit multisynaptic reflex arcs involved in producing and maintaining muscle spasms. This agent is extensively hydroxylated by cytochrome P450 2E1 (CYP2E1) to 6-hydroxychlorzoxazone (HCZ),11,12 which is subsequently glucuronidated and eliminated renally. Highly selective for CYP2E1, CZ may be used as a selective probe for phenotyping CYP2E1 in humans; the ratio of HCZ-to-CZ plasma concentrations obtained 2 to 4 hours after oral administration of CZ may be used as a phenotypic measure of CYP2E1 enzymatic activity. [from NCI]

MedGen UID:
915
Concept ID:
C0008296
Organic Chemical; Pharmacologic Substance
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