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Items: 1 to 20 of 46

1.

Azathioprine

A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. [from NCI]

MedGen UID:
13991
Concept ID:
C0004482
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
2.

Inosine

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed) [from MeSH]

MedGen UID:
9477
Concept ID:
C0021528
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
3.

CI 4

MedGen UID:
94875
Concept ID:
C0387382
Amino Acid, Peptide, or Protein; Pharmacologic Substance
4.

Thioguanine

A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04) [from NCI]

MedGen UID:
21146
Concept ID:
C0039902
Organic Chemical; Pharmacologic Substance
5.

Pancreatitis

INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis. [from MeSH]

MedGen UID:
14586
Concept ID:
C0030305
Disease or Syndrome
6.

Vomiting

Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions. [from HPO]

MedGen UID:
12124
Concept ID:
C0042963
Sign or Symptom
7.

Nausea

A sensation of unease in the stomach together with an urge to vomit. [from HPO]

MedGen UID:
10196
Concept ID:
C0027497
Sign or Symptom
8.

Accumulation

A state characterized by the gradual increase in entities or substances. [from NCI]

MedGen UID:
883922
Concept ID:
C4055506
Finding
9.

Inflammation of the large intestine

MedGen UID:
662273
Concept ID:
C0578878
Pathologic Function
10.

Autoimmune thrombocytopenia

An autoimmune coagulation disorder characterized by isolated thrombocytopenia (a platelet count <100,000/microL), in the absence of any underlying disorder that may be associated with thrombocytopenia. [from SNOMEDCT_US]

MedGen UID:
584986
Concept ID:
C0398650
Disease or Syndrome
11.

Inflammation of the large intestine

MedGen UID:
505065
Concept ID:
CN001842
Finding
12.

Adverse reaction

Any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out. [from NCI]

MedGen UID:
154330
Concept ID:
C0559546
Pathologic Function
13.

Suffering

State of severe distress associated with events that threaten the intactness of the person, can be physical, mental, or emotional. [from SNOMEDCT_US]

MedGen UID:
151916
Concept ID:
C0683278
Mental or Behavioral Dysfunction
14.

Influenza-like symptoms

Complaints describing a pattern similar to influenza, which may include one or more of the following symptoms: fever, chills, muscle or body aches, cough, sore throat, rhinitis, or fatigue. [from NCI]

MedGen UID:
140262
Concept ID:
C0392171
Sign or Symptom
15.

Inflammatory bowel disease

A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type. [from NCI]

MedGen UID:
43877
Concept ID:
C0021390
Disease or Syndrome
16.

Skin rash

A red eruption of the skin. [from HPO]

MedGen UID:
8732
Concept ID:
C0015230
Finding; Sign or Symptom
17.

Immunomodulator

agents of both drug and biological origin often used in immunotherapy to stimulate, potentiate, or depress the immune response; also used to inhibit or enhance specific subclasses of immunocytes. [from CRISP]

MedGen UID:
282900
Concept ID:
C1527392
Immunologic Factor; Pharmacologic Substance
18.

Rectocolitis, Hemorrhagic

MedGen UID:
226206
Concept ID:
C1257847
Disease or Syndrome
19.

Purinethol

MedGen UID:
196307
Concept ID:
C0722911
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
20.

Ileocolitis

MedGen UID:
184943
Concept ID:
C0949272
Disease or Syndrome
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