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Items: 5

1.

Parecoxib

An amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation. [from NCI]

MedGen UID:
214201
Concept ID:
C0915142
Organic Chemical; Pharmacologic Substance
2.

Parecoxib Sodium

A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation. [from NCI]

MedGen UID:
182012
Concept ID:
C0915144
Organic Chemical; Pharmacologic Substance
3.

Pain

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. [from MeSH]

MedGen UID:
45282
Concept ID:
C0030193
Sign or Symptom
4.

Pain

MedGen UID:
880950
Concept ID:
CN236637
Disease or Syndrome
5.

Analgesic

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. [from MeSH]

MedGen UID:
8049
Concept ID:
C0002771
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
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