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Items: 19

1.

Dopamine

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [from NCI]

MedGen UID:
41644
Concept ID:
C0013030
Biologically Active Substance; Neuroreactive Substance or Biogenic Amine; Organic Chemical; Pharmacologic Substance
2.

Bupropion

A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment. [from MeSH]

MedGen UID:
38816
Concept ID:
C0085208
Organic Chemical; Pharmacologic Substance
3.

Increased body weight

A change in overall body weight, relative to the beginning of the collection period. [from NCI_CDISC]

MedGen UID:
12145
Concept ID:
C0043094
Finding
4.

Weight gain

MedGen UID:
881038
Concept ID:
CN236654
Disease or Syndrome
5.

Decreasing

MedGen UID:
617794
Concept ID:
C0442797
Finding; Qualitative Concept
6.

TaqI POLYMORPHISM

MedGen UID:
374172
Concept ID:
C1839238
Disease or Syndrome; Finding
7.

Ameliorated by

Weakened or thinned. Attenuated strains of disease-causing bacteria and viruses are often used as vaccines. The weakened strains are used as vaccines because they stimulate a protective immune response while causing no disease or only mild disease in the person receiving the vaccine. [from NCI_NCI-GLOSS]

MedGen UID:
83049
Concept ID:
C0332161
Qualitative Concept
8.

Pharmaceutical Preparations

You may need to take medicines every day, or only once in a while. Either way, you want to make sure that the medicines are safe and will help you get better. In the United States, the Food and Drug Administration is in charge of assuring the safety and effectiveness of both prescription and over-the-counter medicines. Even safe drugs can cause unwanted side effects or interactions with food or other medicines you may be taking. They may not be safe during pregnancy. To reduce the risk of reactions and make sure that you get better, it is important for you to take your medicines correctly and be careful when giving medicines to children.  [from MedlinePlus]

MedGen UID:
8496
Concept ID:
C0013227
Pharmacologic Substance
9.

Zyntabac

MedGen UID:
304558
Concept ID:
C1450942
Organic Chemical; Pharmacologic Substance
10.

Membrane Transport Modulators

Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS. [from MeSH]

MedGen UID:
288786
Concept ID:
C1563710
Pharmacologic Substance
11.

Quomen

MedGen UID:
260269
Concept ID:
C1450941
Organic Chemical; Pharmacologic Substance
12.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
13.

Neurotransmitter Agents

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. [from MeSH]

MedGen UID:
69321
Concept ID:
C0243051
Pharmacologic Substance
14.

Dopamine Uptake Inhibitors

Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake. [from MeSH]

MedGen UID:
67025
Concept ID:
C0242980
Pharmacologic Substance
15.

Wellbutrin

a depression treatment drug [from CHV]

MedGen UID:
39143
Concept ID:
C0085934
Organic Chemical; Pharmacologic Substance
16.

Neurotransmitter Uptake Inhibitors

Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects. [from MeSH]

MedGen UID:
11888
Concept ID:
C0040724
Pharmacologic Substance
17.

Heredity

The transmission of traits encoded in GENES from parent to offspring. [from MeSH]

MedGen UID:
6814
Concept ID:
C0019266
Molecular Function
18.

Dopaminergic Agents

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. [from MeSH]

MedGen UID:
4380
Concept ID:
C0013036
Pharmacologic Substance
19.

Bupropion Hydrochloride, (+-)-Isomer

MedGen UID:
165759
Concept ID:
C0887733
Organic Chemical; Pharmacologic Substance
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