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Items: 15

1.

Independent

MedGen UID:
721426
Concept ID:
C1299583
Finding
2.

cytotoxicity

The adverse effect of some iatrogenic therapies. It is an accepted side effect in radiation therapy where the desired effect is to kill rapidly growing tumor cells. In the killing of tumor cells, other cells that are rapidly growing e.g hair, mucous membranes are also killed. [from NCI]

MedGen UID:
108579
Concept ID:
C0596402
Cell or Molecular Dysfunction
3.

Immunomodulators

agents of both drug and biological origin often used in immunotherapy to stimulate, potentiate, or depress the immune response; also used to inhibit or enhance specific subclasses of immunocytes. [from CRISP]

MedGen UID:
282900
Concept ID:
C1527392
Immunologic Factor; Pharmacologic Substance
4.

Sequence Deletion

Deletion of sequences of nucleic acids from the genetic material of an individual. [from MeSH]

MedGen UID:
102460
Concept ID:
C0162773
Cell or Molecular Dysfunction
5.

Mutagenesis Process

OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level. [ISBN:0198506732] [from GO]

MedGen UID:
86969
Concept ID:
C0079866
Molecular Function
6.

Vaccines

A Type of medicine that creates an immune protection without the recipient experiencing the disease.  [from HL7]

MedGen UID:
52963
Concept ID:
C0042210
Immunologic Factor; Pharmacologic Substance
7.

Polysaccharide

A large carbohydrate molecule. It contains many small sugar molecules that are joined chemically. [from NCI]

MedGen UID:
46014
Concept ID:
C0032594
Carbohydrate; Organic Chemical; Pharmacologic Substance
8.

Trehalose-6,6'-Dimycolate

MedGen UID:
21250
Concept ID:
C0040817
Biologically Active Substance; Lipid; Organic Chemical; Pharmacologic Substance
9.

Cord Factors

Toxic glycolipids composed of trehalose dimycolate derivatives. They are produced by MYCOBACTERIUM TUBERCULOSIS and other species of MYCOBACTERIUM. They induce cellular dysfunction in animals. [from MeSH]

MedGen UID:
3239
Concept ID:
C0010004
Biologically Active Substance; Lipid; Organic Chemical; Pharmacologic Substance
10.

Immunologic Adjuvants

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. [from MeSH]

MedGen UID:
1759
Concept ID:
C0001551
Immunologic Factor; Pharmacologic Substance
11.

Biological Products

Complex pharmaceutical substances, preparations, or agents of organic origin, usually obtained by biological methods or assay. They are used especially in diagnosis and treatment of disease (as vaccines or pollen extracts). Biological products are differentiated from BIOLOGICAL FACTORS in that the latter are compounds with biological or physiological activity made by living organisms. (From Webster's 3d ed) [from MeSH]

MedGen UID:
577
Concept ID:
C0005522
Biologically Active Substance; Pharmacologic Substance
12.

Ribi adjuvant

MedGen UID:
63633
Concept ID:
C0170750
Lipid; Organic Chemical; Pharmacologic Substance
13.

Immunoglobulin light chain deficiency

MedGen UID:
585017
Concept ID:
C0398697
Disease or Syndrome
14.

KLH-Lymphoma Ig Vaccine

A chimeric lymphoma vaccine generated by combining the recipient's Ig idiotype (Id) protein with keyhole limpet hemocyanin (KLH), an immune stimulant, with potential antineoplastic activity. Vaccination with KLH-Lymphoma Ig Vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against lymphoma cells, resulting in decreased tumor growth. (NCI04) [from NCI]

MedGen UID:
273415
Concept ID:
C1517646
Immunologic Factor; Pharmacologic Substance
15.

Immunoglobulin heavy chain deficiency

A disorder that affects the production of complete immunoglobulins. Deletions in the heavy chain genes on chromosome 14 disrupt the synthesis and secretion of properly functioning antibodies resulting in monoclonal populations of truncated heavy chains without covalently bonded light chains. Such deletions have been implicated as playing a significant role in several diseases including leukemias, lymphomas and myelomas. [from NCI]

MedGen UID:
98309
Concept ID:
C0398692
Disease or Syndrome
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