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Items: 5

1.

brilliant black

MedGen UID:
155158
Concept ID:
C0602865
Organic Chemical; Pharmacologic Substance
2.

Micronucleus

A toxicology screening result where proliferating cells that are exposed to a genotoxic chemical produce some daughter cells containing cytoplasmic bodies that are comprised of chromosomes or chromosome fragments, which were not sorted properly during mitosis or meiosis, and are bounded by a nuclear membrane. [from NCI]

MedGen UID:
507946
Concept ID:
C0026004
Finding
3.

DNA Fragmentation

Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS. [from MeSH]

MedGen UID:
138244
Concept ID:
C0376669
Molecular Function
4.

DNA damage

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. [from MeSH]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
5.

C.I. 27260

MedGen UID:
110324
Concept ID:
C0602864
Organic Chemical; Pharmacologic Substance
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