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Items: 11

1.

Proliferative vitreoretinopathy

Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes. [from MeSH]

MedGen UID:
66167
Concept ID:
C0242852
Disease or Syndrome
2.

Cytotoxicity

The adverse effect of some iatrogenic therapies. It is an accepted side effect in radiation therapy where the desired effect is to kill rapidly growing tumor cells. In the killing of tumor cells, other cells that are rapidly growing e.g hair, mucous membranes are also killed. [from NCI]

MedGen UID:
108579
Concept ID:
C0596402
Cell or Molecular Dysfunction
3.

Adhesion

A fibrous band of tissue that connects normally separate body regions.(NICHD) [from NCI]

MedGen UID:
7891
Concept ID:
C0001511
Pathologic Function
4.

Ro-236019

MedGen UID:
214655
Concept ID:
C0919268
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
5.

Tetradecanoylphorbol Acetate

A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04) [from NCI]

MedGen UID:
21493
Concept ID:
C0039654
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
6.

Protein binding

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. [from MeSH]

MedGen UID:
18704
Concept ID:
C0033618
Molecular Function
7.

Competitive binding

The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements. [from MeSH]

MedGen UID:
14124
Concept ID:
C0005458
Molecular Function
8.

Immunoglobulin G

An immunoglobulin isotype (subclass) that characterizes secondary immune responses. This isotype is further broken down into several smaller subclasses (IgG1, IgG2a, IgG2b, IgG3 in the mouse; IgG1-4 in the human), and each subclass is differentially synthesized and secreted into the serum upon differential immune stimuli. [from NCI]

MedGen UID:
9407
Concept ID:
C0020852
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
9.

Interferon

Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. [from MeSH]

MedGen UID:
5847
Concept ID:
C0021747
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
10.

Interferon gamma

Interferon gamma (166 aa, ~19 kDa) is encoded by the human IFNG gene. This protein is involved in antiviral activity, macrophage activation, antiproliferative activity and immunopotentiation. [from NCI]

MedGen UID:
5846
Concept ID:
C0021745
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
11.

Terpenes allergy

MedGen UID:
654947
Concept ID:
C0571176
Disease or Syndrome
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