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Items: 1 to 20 of 48

1.

Warfarin

A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. [from NCI]

MedGen UID:
22695
Concept ID:
C0043031
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
2.

Coagulation factor deficiency syndrome

Includes both quantitative and qualitative disorders of procoagulants [from SNOMEDCT_US]

MedGen UID:
543969
Concept ID:
C0272315
Disease or Syndrome
3.

Warfarin response

Warfarin is an oral anti-coagulant used world-wide to treat and prevent thrombotic disorders. While it is highly effective, it has a very narrow therapeutic index making it difficult to dose correctly. Genetic variants in both cytochrome P450-2C9 (CYP2C9) and vitamin K-epoxide reductase complex (VKORC1) enzymes, along with non-genetic factors, are known to affect warfarin dose variability. Patients with specific variants in the gene CYP2C9 (the primary warfarin-metabolizing enzyme), such as CYP2C9*2 and CYP2C9*3, may require a lower dose of warfarin as compared to patients without these variants. Patients with a specific variant in VKORC1 (the target enzyme of warfarin), known as -1639G>A or rs9923231, may require a lower warfarin dose as compared to patients who do not have this variant. The combination of CYP2C9 and VKORC1 genetic variants, along with clinical factors, can put some patients at risk for adverse events such as bleeding. Guidelines regarding the use of pharmacogenomic tests in dosing for warfarin have been published in Clinical Pharmacology and Therapeutics by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and are available on the PharmGKB website. [from GTR]

MedGen UID:
450501
Concept ID:
CN078029
Sign or Symptom
4.

Blood clotting factor

Endogenous substances, usually proteins, that are involved in the blood coagulation process. [from MeSH]

MedGen UID:
605
Concept ID:
C0005789
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
5.

Coumarinic anhydride

O hydroxycinnamic acid. Pleasant smelling compound found in many plants and released on wilting. Has anticoagulant activity by competing with Vitamin K.(from On-line Medical Dictionary) [from NCI]

MedGen UID:
41327
Concept ID:
C0010206
Organic Chemical; Pharmacologic Substance
6.

Vitamin K>2<

A group of substances similar to VITAMIN K 1 which contains a ring of 2-methyl-1,4-naphthoquinione and an isoprenoid side chain of varying number of isoprene units. In vitamin K 2, each isoprene unit contains a double bond. They are produced by bacteria including the normal intestinal flora. [from MeSH]

MedGen UID:
39473
Concept ID:
C0086605
Organic Chemical; Pharmacologic Substance; Vitamin
7.

Hydroquinone

Produced as an inhibitor, an antioxidant, and an intermediate in the synthesis of dyes, motor fuels, and oils; in photographic processing; and naturally in certain plant species, Hydroquinone is a phenol derivative with antioxidant properties that can cause toxicity in several organs, notably the kidney. Used as a topical treatment for skin hyperpigmentation and in various cosmetic products, it is metabolized mainly to glutathione conjugates and forms mutagenic DNA adducts in in-vitro systems. (NCI04) [from NCI]

MedGen UID:
6948
Concept ID:
C0020306
Organic Chemical; Pharmacologic Substance
8.

Coumarins

Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid. [from MeSH]

MedGen UID:
1156
Concept ID:
C0010207
Organic Chemical; Pharmacologic Substance
9.

Vitamin K-Dependent Clotting Factors

MedGen UID:
893582
Concept ID:
CN239236
Disease or Syndrome
10.

Thromboembolism

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
505000
Concept ID:
CN001725
Finding
11.

Mode of inheritance

The pattern in which a particular genetic trait or disorder is passed from one generation to the next. [from HPO]

MedGen UID:
353811
Concept ID:
C1708511
Genetic Function
12.

Vitamin k-dependent clotting factors, combined deficiency of, 2

Deficiency of all vitamin K-dependent clotting factors leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. Familial multiple coagulation factor deficiency is rare. Clinical symptoms of the disease include episodes of intracranial hemorrhage in the first weeks of life, sometimes leading to a fatal outcome (Fregin et al., 2002). [from GTR]

MedGen UID:
334505
Concept ID:
C1843832
Disease or Syndrome
13.

Embolism and thrombosis

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
43147
Concept ID:
C0085307
Disease or Syndrome
14.

Vitamin preparation

A group of organic food substances found in animals and plants in small quantities. They must be supplied in diet or dietary supplement and are essential for normal metabolism. [from NCI]

MedGen UID:
12117
Concept ID:
C0042890
Organic Chemical; Pharmacologic Substance; Vitamin
15.

Anticoagulant

Agents that prevent BLOOD CLOTTING. [from MeSH]

MedGen UID:
1970
Concept ID:
C0003280
Pharmacologic Substance
16.

Tedicumar

MedGen UID:
327754
Concept ID:
C1564396
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
17.

Coumadine

MedGen UID:
327753
Concept ID:
C1564394
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
18.

Aldocumar

MedGen UID:
296050
Concept ID:
C1564393
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
19.

Gen-Warfarin

MedGen UID:
296049
Concept ID:
C1564392
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
20.

Warfant

MedGen UID:
289814
Concept ID:
C1564397
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
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