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Items: 1 to 20 of 41

1.

Lopinavir

A peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related drug ritonavir. [from NCI]

MedGen UID:
145897
Concept ID:
C0674432
Organic Chemical; Pharmacologic Substance
2.

Ritonavir

A peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cytochrome P450. [from NCI]

MedGen UID:
132886
Concept ID:
C0292818
Organic Chemical; Pharmacologic Substance
3.

Nelfinavir

A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. [from MeSH]

MedGen UID:
105646
Concept ID:
C0525005
Organic Chemical; Pharmacologic Substance
4.

Stavudine

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. [from MeSH]

MedGen UID:
103901
Concept ID:
C0164662
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
5.

Lamivudine

A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease. [from MeSH]

MedGen UID:
64917
Concept ID:
C0209738
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
6.

Lopinavir+ritonavir

A fixed combination of two protease inhibitors, lopinavir and ritonavir, used to treat human immunodeficiency virus (HIV) infection. The ritonavir in the combination drug increases the concentration and biological half-life of lopinavir but is not present in sufficient concentration to act as a protease inhibitor. [from NCI]

MedGen UID:
215250
Concept ID:
C0939237
Pharmacologic Substance
7.

Peptide hydrolase inhibitor

Any substance that inhibits a protease, an enzyme that breaks peptide bonds. Proteases are required for many cell processes and inhibition of proteases can inhibit viral replication, inflammatory responses, proliferation, and tumor growth. [from NCI]

MedGen UID:
18701
Concept ID:
C0033607
Pharmacologic Substance
8.

Human immunodeficiency virus

MedGen UID:
842721
Concept ID:
C3854222
Disease or Syndrome
9.

Immunodeficiency

Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral. [from MeSH]

MedGen UID:
7034
Concept ID:
C0021051
Disease or Syndrome
10.

Hiv

An infection caused by the human immunodeficiency virus. [from NCI]

MedGen UID:
5583
Concept ID:
C0019693
Disease or Syndrome
11.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
12.

Antimicrobial substance

Generically, any agent that destroys microbes. However, usage of the term is increasingly being confined to agents that prevent or reduce the transmission of SEXUALLY TRANSMITTED DISEASES. [from MeSH]

MedGen UID:
209727
Concept ID:
C1136254
Pharmacologic Substance
13.

A-157378.0

MedGen UID:
205108
Concept ID:
C1110556
Organic Chemical; Pharmacologic Substance
14.

Zerit

MedGen UID:
196126
Concept ID:
C0701312
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
15.

Norvir

MedGen UID:
195697
Concept ID:
C0678152
Organic Chemical; Pharmacologic Substance
16.

GR109714X

MedGen UID:
152738
Concept ID:
C0733528
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
17.

NSC-606170

MedGen UID:
152737
Concept ID:
C0733527
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
18.

BMY-27857

MedGen UID:
148750
Concept ID:
C0701313
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
19.

Epivir

MedGen UID:
146253
Concept ID:
C0678151
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
20.

Hivid

MedGen UID:
146249
Concept ID:
C0678123
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
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