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Golgi Targeting

MedGen UID:
268807
Concept ID:
C1512241
Molecular Function
 

Definition

1) To direct or use toward the Golgi apparatus as a target. Targeting of the Golgi apparatus by specific substances to disrupt or alter its function. 2) Related to structural elements in a protein, such as a peptide sequence, that directs the localization of a protein or protein complex to the Golgi apparatus. [from NCI]

Recent clinical studies

Etiology

Yuan C, Smith WL
J Biol Chem 2015 Feb 27;290(9):5606-20. Epub 2014 Dec 29 doi: 10.1074/jbc.M114.632463. PMID: 25548276Free PMC Article
Lu L, Tai G, Wu M, Song H, Hong W
Traffic 2006 Oct;7(10):1399-407. Epub 2006 Aug 10 doi: 10.1111/j.1600-0854.2006.00473.x. PMID: 16899086
Han Z, Harty RN
J Biol Chem 2004 Oct 8;279(41):43092-7. Epub 2004 Aug 3 doi: 10.1074/jbc.M403663200. PMID: 15292261
Barr FA
Curr Biol 1999 Apr 8;9(7):381-4. PMID: 10209123

Diagnosis

Egerer J, Emmerich D, Fischer-Zirnsak B, Chan WL, Meierhofer D, Tuysuz B, Marschner K, Sauer S, Barr FA, Mundlos S, Kornak U
J Invest Dermatol 2015 Oct;135(10):2368-2376. Epub 2015 May 22 doi: 10.1038/jid.2015.192. PMID: 26000619
Petrosyan A, Holzapfel MS, Muirhead DE, Cheng PW
Mol Cancer Res 2014 Dec;12(12):1704-16. Epub 2014 Aug 1 doi: 10.1158/1541-7786.MCR-14-0291-T. PMID: 25086069Free PMC Article
Nishimura T, Uchida Y, Yachi R, Kudlyk T, Lupashin V, Inoue T, Taguchi T, Arai H
Mol Biol Cell 2013 Nov;24(22):3534-44. Epub 2013 Sep 18 doi: 10.1091/mbc.E13-05-0250. PMID: 24048449Free PMC Article
Bertolotti-Ciarlet A, Smith J, Strecker K, Paragas J, Altamura LA, McFalls JM, Frias-Stäheli N, García-Sastre A, Schmaljohn CS, Doms RW
J Virol 2005 May;79(10):6152-61. doi: 10.1128/JVI.79.10.6152-6161.2005. PMID: 15858000Free PMC Article
Kjer-Nielsen L, van Vliet C, Erlich R, Toh BH, Gleeson PA
J Cell Sci 1999 Jun;112 ( Pt 11):1645-54. PMID: 10318758

Therapy

Kawano M, Kumagai K, Nishijima M, Hanada K
J Biol Chem 2006 Oct 6;281(40):30279-88. Epub 2006 Aug 8 doi: 10.1074/jbc.M605032200. PMID: 16895911

Prognosis

Li Y, Surya W, Claudine S, Torres J
J Biol Chem 2014 May 2;289(18):12535-49. Epub 2014 Mar 25 doi: 10.1074/jbc.M114.560094. PMID: 24668816Free PMC Article
Nissilä E, Ohsaki Y, Weber-Boyvat M, Perttilä J, Ikonen E, Olkkonen VM
Biochim Biophys Acta 2012 Dec;1821(12):1472-84. Epub 2012 Aug 11 doi: 10.1016/j.bbalip.2012.08.004. PMID: 22906437
Montori-Grau M, Guitart M, García-Martínez C, Orozco A, Gómez-Foix AM
BMC Biochem 2011 Nov 4;12:57. doi: 10.1186/1471-2091-12-57. PMID: 22054094Free PMC Article
Puri S, Bachert C, Fimmel CJ, Linstedt AD
Traffic 2002 Sep;3(9):641-53. PMID: 12191016
Hicks SW, Machamer CE
J Biol Chem 2002 Sep 27;277(39):35833-9. Epub 2002 Jul 18 doi: 10.1074/jbc.M206280200. PMID: 12130652

Clinical prediction guides

Li Y, Surya W, Claudine S, Torres J
J Biol Chem 2014 May 2;289(18):12535-49. Epub 2014 Mar 25 doi: 10.1074/jbc.M114.560094. PMID: 24668816Free PMC Article
Nissilä E, Ohsaki Y, Weber-Boyvat M, Perttilä J, Ikonen E, Olkkonen VM
Biochim Biophys Acta 2012 Dec;1821(12):1472-84. Epub 2012 Aug 11 doi: 10.1016/j.bbalip.2012.08.004. PMID: 22906437
Montori-Grau M, Guitart M, García-Martínez C, Orozco A, Gómez-Foix AM
BMC Biochem 2011 Nov 4;12:57. doi: 10.1186/1471-2091-12-57. PMID: 22054094Free PMC Article
Modiano N, Lu YE, Cresswell P
Proc Natl Acad Sci U S A 2005 Jun 14;102(24):8680-5. Epub 2005 Jun 3 doi: 10.1073/pnas.0503227102. PMID: 15937107Free PMC Article
Hardt B, Völker C, Mundt S, Salska-Navarro M, Hauptmann M, Bause E
Biochimie 2005 Feb;87(2):169-79. doi: 10.1016/j.biochi.2004.11.004. PMID: 15760709

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