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Carcinoid heart disease

MedGen UID:
762
Concept ID:
C0007093
Disease or Syndrome
Synonyms: Carcinoid Heart Disease; Carcinoid Heart Diseases; Heart Disease, Carcinoid; Heart Diseases, Carcinoid
SNOMED CT: Carcinoid heart disease (36222008)
 

Definition

Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoid heart disease

Recent clinical studies

Etiology

Baur AD, Kunz F, Schwenke C, Pschowski R, Röpke TK, Pavel M, Denecke T
J Comput Assist Tomogr 2016 Mar-Apr;40(2):277-82. doi: 10.1097/RCT.0000000000000354. PMID: 26760186
Dobson R, Burgess MI, Valle JW, Pritchard DM, Vora J, Wong C, Chadwick C, Keevi B, Adaway J, Hofmann U, Poston GJ, Cuthbertson DJ
Br J Cancer 2014 Oct 28;111(9):1703-9. Epub 2014 Sep 11 doi: 10.1038/bjc.2014.468. PMID: 25211656Free PMC Article
Requilé A, Van De Bruaene A, Reenaers V, Dendale P
Echocardiography 2014 Nov;31(10):E307-9. Epub 2014 Aug 5 doi: 10.1111/echo.12713. PMID: 25092066
Manoly I, McAnelly SL, Sriskandarajah S, McLaughlin KE
Interact Cardiovasc Thorac Surg 2014 Aug;19(2):302-5. Epub 2014 May 8 doi: 10.1093/icvts/ivu146. PMID: 24812331
Bhattacharyya S, Toumpanakis C, Chilkunda D, Caplin ME, Davar J
Am J Cardiol 2011 Apr 15;107(8):1221-6. Epub 2011 Feb 4 doi: 10.1016/j.amjcard.2010.12.025. PMID: 21296329

Diagnosis

Baur AD, Kunz F, Schwenke C, Pschowski R, Röpke TK, Pavel M, Denecke T
J Comput Assist Tomogr 2016 Mar-Apr;40(2):277-82. doi: 10.1097/RCT.0000000000000354. PMID: 26760186
Dobson R, Valle JW, Burgess MI, Poston GJ, Cuthbertson DJ
Clin Oncol (R Coll Radiol) 2015 Dec;27(12):741-6. Epub 2015 Jul 11 doi: 10.1016/j.clon.2015.06.016. PMID: 26170123
Dobson R, Burgess MI, Valle JW, Pritchard DM, Vora J, Wong C, Chadwick C, Keevi B, Adaway J, Hofmann U, Poston GJ, Cuthbertson DJ
Br J Cancer 2014 Oct 28;111(9):1703-9. Epub 2014 Sep 11 doi: 10.1038/bjc.2014.468. PMID: 25211656Free PMC Article
Dobson R, Burgess MI, Banks M, Pritchard DM, Vora J, Valle JW, Wong C, Chadwick C, George K, Keevil B, Adaway J, Ardill JE, Anthoney A, Hofmann U, Poston GJ, Cuthbertson DJ
PLoS One 2013;8(9):e73679. Epub 2013 Sep 12 doi: 10.1371/journal.pone.0073679. PMID: 24069222Free PMC Article
Bhattacharyya S, Toumpanakis C, Chilkunda D, Caplin ME, Davar J
Am J Cardiol 2011 Apr 15;107(8):1221-6. Epub 2011 Feb 4 doi: 10.1016/j.amjcard.2010.12.025. PMID: 21296329

Therapy

Edwards NC, Yuan M, Nolan O, Pawade TA, Oelofse T, Singh H, Mehrzad H, Zia Z, Geh JI, Palmer DH, May CJ, Ayuk J, Shah T, Rooney SJ, Steeds RP
J Clin Endocrinol Metab 2016 Jan;101(1):183-90. Epub 2015 Nov 18 doi: 10.1210/jc.2015-3295. PMID: 26580239
Patel C, Mathur M, Escarcega RO, Bove AA
Am Heart J 2014 Jun;167(6):789-95. Epub 2014 Apr 5 doi: 10.1016/j.ahj.2014.03.018. PMID: 24890526
Manoly I, McAnelly SL, Sriskandarajah S, McLaughlin KE
Interact Cardiovasc Thorac Surg 2014 Aug;19(2):302-5. Epub 2014 May 8 doi: 10.1093/icvts/ivu146. PMID: 24812331
Palaniswamy C, Frishman WH, Aronow WS
Cardiol Rev 2012 Jul-Aug;20(4):167-76. doi: 10.1097/CRD.0b013e31824c866e. PMID: 22314145
Bhattacharyya S, Raja SG, Toumpanakis C, Caplin ME, Dreyfus GD, Davar J
Eur J Cardiothorac Surg 2011 Jul;40(1):168-72. Epub 2010 Dec 14 doi: 10.1016/j.ejcts.2010.10.035. PMID: 21156347

Prognosis

Baur AD, Kunz F, Schwenke C, Pschowski R, Röpke TK, Pavel M, Denecke T
J Comput Assist Tomogr 2016 Mar-Apr;40(2):277-82. doi: 10.1097/RCT.0000000000000354. PMID: 26760186
Dobson R, Burgess MI, Valle JW, Pritchard DM, Vora J, Wong C, Chadwick C, Keevi B, Adaway J, Hofmann U, Poston GJ, Cuthbertson DJ
Br J Cancer 2014 Oct 28;111(9):1703-9. Epub 2014 Sep 11 doi: 10.1038/bjc.2014.468. PMID: 25211656Free PMC Article
Manoly I, McAnelly SL, Sriskandarajah S, McLaughlin KE
Interact Cardiovasc Thorac Surg 2014 Aug;19(2):302-5. Epub 2014 May 8 doi: 10.1093/icvts/ivu146. PMID: 24812331
Dobson R, Burgess MI, Banks M, Pritchard DM, Vora J, Valle JW, Wong C, Chadwick C, George K, Keevil B, Adaway J, Ardill JE, Anthoney A, Hofmann U, Poston GJ, Cuthbertson DJ
PLoS One 2013;8(9):e73679. Epub 2013 Sep 12 doi: 10.1371/journal.pone.0073679. PMID: 24069222Free PMC Article
Bhattacharyya S, Toumpanakis C, Chilkunda D, Caplin ME, Davar J
Am J Cardiol 2011 Apr 15;107(8):1221-6. Epub 2011 Feb 4 doi: 10.1016/j.amjcard.2010.12.025. PMID: 21296329

Clinical prediction guides

Baur AD, Kunz F, Schwenke C, Pschowski R, Röpke TK, Pavel M, Denecke T
J Comput Assist Tomogr 2016 Mar-Apr;40(2):277-82. doi: 10.1097/RCT.0000000000000354. PMID: 26760186
Dobson R, Valle JW, Burgess MI, Poston GJ, Cuthbertson DJ
Clin Oncol (R Coll Radiol) 2015 Dec;27(12):741-6. Epub 2015 Jul 11 doi: 10.1016/j.clon.2015.06.016. PMID: 26170123
Dobson R, Burgess MI, Banks M, Pritchard DM, Vora J, Valle JW, Wong C, Chadwick C, George K, Keevil B, Adaway J, Ardill JE, Anthoney A, Hofmann U, Poston GJ, Cuthbertson DJ
PLoS One 2013;8(9):e73679. Epub 2013 Sep 12 doi: 10.1371/journal.pone.0073679. PMID: 24069222Free PMC Article
Castillo JG, Silvay G, Solís J
Semin Cardiothorac Vasc Anesth 2013 Sep;17(3):212-23. Epub 2012 Nov 20 doi: 10.1177/1089253212465475. PMID: 23171718
Bhattacharyya S, Toumpanakis C, Chilkunda D, Caplin ME, Davar J
Am J Cardiol 2011 Apr 15;107(8):1221-6. Epub 2011 Feb 4 doi: 10.1016/j.amjcard.2010.12.025. PMID: 21296329

Recent systematic reviews

Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants.
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Manoly I, McAnelly SL, Sriskandarajah S, McLaughlin KE
Interact Cardiovasc Thorac Surg 2014 Aug;19(2):302-5. Epub 2014 May 8 doi: 10.1093/icvts/ivu146. PMID: 24812331
Seymour N, Sawh SC
Can J Anaesth 2013 May;60(5):492-9. Epub 2013 Jan 18 doi: 10.1007/s12630-012-9879-1. PMID: 23328959
Plöckinger U, Gustafsson B, Ivan D, Szpak W, Davar J; Mallorca Consensus Conference participants.; European Neuroendocrine Tumor Society.
Neuroendocrinology 2009;90(2):190-3. Epub 2009 Aug 28 doi: 10.1159/000225947. PMID: 19713710

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