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1.

Lymphoma

Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is Hodgkin disease. The rest are called non-Hodgkin lymphomas. Non-Hodgkin lymphomas begin when a type of white blood cell, called a T cell or B cell, becomes abnormal. The cell divides again and again, making more and more abnormal cells. These abnormal cells can spread to almost any other part of the body. Most of the time, doctors don't know why a person gets non-Hodgkin lymphoma. You are at increased risk if you have a weakened immune system or have certain types of infections. Non-Hodgkin lymphoma can cause many symptoms, such as . -Swollen, painless lymph nodes in the neck, armpits or groin. -Unexplained weight loss . -Fever . -Soaking night sweats . -Coughing, trouble breathing or chest pain . -Weakness and tiredness that don't go away . -Pain, swelling or a feeling of fullness in the abdomen . Your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. Treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. Targeted therapy uses substances that attack cancer cells without harming normal cells. Biologic therapy boosts your body's own ability to fight cancer. If you don't have symptoms, you may not need treatment right away. This is called watchful waiting. NIH: National Cancer Institute.  [from MedlinePlus]

MedGen UID:
44223
Concept ID:
C0024299
Neoplastic Process
2.

Hodgkin lymphoma

Hodgkin lymphoma (HL) is a heterogeneous group of malignant lymphoid neoplasms of B-cell origin characterized histologically by the presence of Hodgkin and Reed-Sternberg (HRS) cells in the vast majority of cases. [from ORDO]

MedGen UID:
799611
Concept ID:
CN206988
Disease or Syndrome
3.

Hodgkin lymphoma

A typer of lymphoma characterized microscopically by multinucleated Reed-Sternberg cells. [from HPO]

MedGen UID:
776519
Concept ID:
CN167915
Finding
4.

Lymphoma

A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells. [from HPO]

MedGen UID:
505322
Concept ID:
CN002422
Finding
5.

Hodgkin lymphoma

Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009). [from OMIM]

MedGen UID:
9283
Concept ID:
C0019829
Neoplastic Process
6.

Frequency

MedGen UID:
91210
Concept ID:
C0376249
Temporal Concept
7.

Risk factor

Something that increases the chance of developing a disease. Some examples of risk factors for cancer are age, a family history of certain cancers, use of tobacco products, being exposed to radiation or certain chemicals, infection with certain viruses or bacteria, and certain genetic changes. [from NCI_NCI-GLOSS]

MedGen UID:
48477
Concept ID:
C0035648
Finding
8.

First Relapse

The reemergence of a disorder as diagnosed by clinical and/or laboratory evidence following a single documented period of remission. [from NCI]

MedGen UID:
885107
Concept ID:
C4054953
Finding
9.

Employed

MedGen UID:
642401
Concept ID:
C0557351
Finding
10.

B-Symptoms

Features commonly associated with lymphoma, including fever above 38C, drenching night sweats, and weight loss of more than 10% of body mass in the previous 6 months. B symptoms are signs of a poor prognosis in patients with lymphoma. [from NCI]

MedGen UID:
353402
Concept ID:
C1706867
Finding
11.

Unlikely

Having little chance of being the case or of coming about. [from NCI]

MedGen UID:
152899
Concept ID:
C0750558
Finding
12.

Base Pairing

Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule. [GOC:krc] [from GO]

MedGen UID:
108706
Concept ID:
C0600436
Molecular Function
13.

Frequent

Coming at short intervals or in great quantities. [from NCI]

MedGen UID:
87144
Concept ID:
C0332183
Temporal Concept
14.

Central

Applies to an abnormality that is located close to the median plane or midline of the body or of the referenced structure. [from HPO]

MedGen UID:
59958
Concept ID:
C0205099
Spatial Concept
15.

Lymphatism

MedGen UID:
141817
Concept ID:
C0524631
Disease or Syndrome
16.

Epstein-Barr virus disease

Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY). [from MeSH]

MedGen UID:
57439
Concept ID:
C0149678
Disease or Syndrome
17.

VP-2

MedGen UID:
57339
Concept ID:
C0148584
Organic Chemical; Pharmacologic Substance
18.

Viral disease

Viruses are capsules with genetic material inside. They are very tiny, much smaller than bacteria. Viruses cause familiar infectious diseases such as the common cold, flu and warts. They also cause severe illnesses such as HIV/AIDS, smallpox and hemorrhagic fevers. . Viruses are like hijackers. They invade living, normal cells and use those cells to multiply and produce other viruses like themselves. This eventually kills the cells, which can make you sick. Viral infections are hard to treat because viruses live inside your body's cells. They are protected from medicines, which usually move through your bloodstream. Antibiotics do not work for viral infections. There are a few antiviral medicines available. Vaccines can help prevent you from getting many viral diseases. NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

MedGen UID:
53027
Concept ID:
C0042769
Disease or Syndrome
19.

Papilloma, Shope

papillomatous growth found in wild cottontail rabbits that is caused by a virus in the family Papovaviridae and can be transferred to domestic rabbits where it will cause similar growths; marked by the formation of horny warts, a high percentage of these growths may become malignant. [from CRISP]

MedGen UID:
45305
Concept ID:
C0030357
Neoplastic Process
20.

DNA Virus Infections

Diseases caused by DNA VIRUSES. [from MeSH]

MedGen UID:
41636
Concept ID:
C0012922
Disease or Syndrome
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