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Items: 5

1.

Valacyclovir product

The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicella-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase. [from NCI]

MedGen UID:
70357
Concept ID:
C0249458
Organic Chemical; Pharmacologic Substance
2.

Fatigue

A subjective feeling of tiredness characterized by a lack of energy and motivation. [from HPO]

MedGen UID:
41971
Concept ID:
C0015672
Sign or Symptom
3.

Chronic fatigue

Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer. [from HPO]

MedGen UID:
760077
Concept ID:
C0518656
Finding
4.

Left

Being located on the left side of the body. [from HPO]

MedGen UID:
618170
Concept ID:
C0443246
Spatial Concept
5.

Chronic fatigue syndrome

A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9) [from MeSH]

MedGen UID:
5130
Concept ID:
C0015674
Disease or Syndrome
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