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Items: 20

1.

Dopamine

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [from NCI]

MedGen UID:
41644
Concept ID:
C0013030
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
2.

AGON

Used with chemicals, drugs, and endogenous substances to indicate substances or agents that have affinity for a receptor and intrinsic activity at that receptor. (From Textbook of Pharmacology, 1991, p.16) [from MeSH]

MedGen UID:
116746
Concept ID:
C0243192
Pharmacologic Substance
3.

Acid, Aminobutyric

MedGen UID:
113108
Concept ID:
C0220780
Amino Acid, Peptide, or Protein; Pharmacologic Substance
4.

Quinpirole

A dopamine D2/D3 receptor agonist. [from MeSH]

MedGen UID:
75025
Concept ID:
C0072892
Organic Chemical; Pharmacologic Substance
5.

Adenosine preparation

A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. [from MeSH]

MedGen UID:
127
Concept ID:
C0001443
Biologically Active Substance; Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
6.

Agonist

An agent that has affinity for a receptor and intrinsic activity at that receptor. [from NCI]

MedGen UID:
459858
Concept ID:
C2987634
Pharmacologic Substance
7.

Receptor Signaling

An intercellular process that involves a cellular receptor binding to a cognate ligand and results in a specific cellular response. [from NCI]

MedGen UID:
271464
Concept ID:
C1514762
Molecular Function
8.

Triggered by

A trigger is defined as an external factor that leads to the manifestation of a sign or symptom in a person with a susceptibility to developing that manifestation. [from HPO]

MedGen UID:
252950
Concept ID:
C1444748
Qualitative Concept
9.

Signaling Pathway

An elaboration of the known or inferred interactions involved in a signal transduction pathway. [from NCI]

MedGen UID:
39530
Concept ID:
C0086982
Molecular Function
10.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
11.

Magnesiocard

MedGen UID:
195605
Concept ID:
C0677518
Amino Acid, Peptide, or Protein; Pharmacologic Substance
12.

Intropin

MedGen UID:
147406
Concept ID:
C0721081
Organic Chemical; Pharmacologic Substance
13.

Agonists, Excitatory Amino Acid

Drugs that bind to and activate excitatory amino acid receptors. [from MeSH]

MedGen UID:
116699
Concept ID:
C0242909
Pharmacologic Substance
14.

Excitatory Amino Acid Agents

Drugs used for their actions on any aspect of excitatory amino acid neurotransmitter systems. Included are drugs that act on excitatory amino acid receptors, affect the life cycle of excitatory amino acid transmitters, or affect the survival of neurons using excitatory amino acids. [from MeSH]

MedGen UID:
116696
Concept ID:
C0242900
Pharmacologic Substance
15.

Neurotransmitter Agents

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. [from MeSH]

MedGen UID:
69321
Concept ID:
C0243051
Pharmacologic Substance
16.

METHYLASPARTATE N

An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA). [from MeSH]

MedGen UID:
36348
Concept ID:
C0079883
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
17.

Mg-5-Longoral

MedGen UID:
9851
Concept ID:
C0024470
Amino Acid, Peptide, or Protein; Pharmacologic Substance
18.

Biogenic amine

A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology. [from MeSH]

MedGen UID:
2255
Concept ID:
C0005496
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
19.

Catecholamine

A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine. [from MeSH]

MedGen UID:
805
Concept ID:
C0007412
Biologically Active Substance; Pharmacologic Substance
20.

Amino acid

Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
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