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Items: 1 to 20 of 59

1.

Coronary artery disease

Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); previous myocardial infarction. (ACC) [from NCI]

MedGen UID:
365486
Concept ID:
C1956346
Disease or Syndrome
2.

Human insulin product

Regular insulin preparations that contain the HUMAN insulin peptide sequence. [from MeSH]

MedGen UID:
162753
Concept ID:
C0795635
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
3.

Protein Cleavage

Protein Cleavage involves hydrolysis by proteolytic enzymes of specific peptide bond(s), forming smaller polypeptides in the target protein during maturation or modification of functional activity. [from NCI]

MedGen UID:
108934
Concept ID:
C0597304
Molecular Function
4.

Metabolic syndrome X

A clustering of abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol (HDLC), high blood pressure, and elevated fasting glucose levels is sometimes called metabolic syndrome X (Reaven, 1988) or abdominal obesity-metabolic syndrome (Bjorntorp, 1991). The syndrome may affect nearly 1 in 4 U.S. adults and is considered a veritable epidemic (Ford et al., 2002). It is a major risk factor for both diabetes mellitus (see 125853 and Haffner et al., 1992) and cardiovascular disease (Isomaa et al., 2001). The etiology is complex, determined by the interplay of both genetic and environmental factors. The prevalence varies substantially among ethnic groups, with the highest rates in Mexican American women (Park et al., 2003). Other factors influencing the metabolic syndrome include age, smoking, alcohol, diet, and physical inactivity. Genetic Heterogeneity of Abdominal Obesity-Metabolic Syndrome AOMS2 (605572) has been mapped to chromosome 17p12. AOMS3 (615812) is caused by mutation in the DYRK1B gene (604556) on chromosome 19q13. [from GTR]

MedGen UID:
99356
Concept ID:
C0524620
Disease or Syndrome
5.

Risk factor

An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, on the basis of epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. [from MeSH]

MedGen UID:
48477
Concept ID:
C0035648
Finding
6.

Insulin resistance

Decreased sensitivity to circulating insulin which may result in acanthosis nigicrans, elevated insulin level or hyperglycemia. [from NCI]

MedGen UID:
43904
Concept ID:
C0021655
Pathologic Function
7.

Hypertriglyceridemia

A condition of elevated levels of TRIGLYCERIDES in the blood. [from MeSH]

MedGen UID:
43788
Concept ID:
C0020557
Disease or Syndrome
8.

Atherosclerosis

A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow. [from HPO]

MedGen UID:
13948
Concept ID:
C0004153
Disease or Syndrome
9.

Syndrome

A characteristic symptom complex. [from MeSH]

MedGen UID:
11688
Concept ID:
C0039082
Disease or Syndrome
10.

Lipase preparation

An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3. [from MeSH]

MedGen UID:
9778
Concept ID:
C0023764
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
11.

Inflammation

A localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. [from NCI]

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
12.

Hypertension

Blood pressure that is abnormally high. [from NCI]

MedGen UID:
6969
Concept ID:
C0020538
Disease or Syndrome
13.

Regular insulin

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). [from MeSH]

MedGen UID:
5827
Concept ID:
C0021641
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
14.

Coronary Artery Disease

MedGen UID:
881070
Concept ID:
CN236626
Disease or Syndrome
15.

Combined hyperlipidemia

MedGen UID:
833258
Concept ID:
CN205835
Finding
16.

Cold agglutinin disease

Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C). [from ORDO]

MedGen UID:
798230
Concept ID:
CN205305
Disease or Syndrome
17.

Low density serum cholesterol level

MedGen UID:
776850
Concept ID:
CN185700
Finding
18.

Hypertension

A finding of increased blood pressure; not necessarily hypertensive disorder [from SNOMEDCT_US]

MedGen UID:
635666
Concept ID:
C0497247
Finding
19.

Very low

MedGen UID:
617805
Concept ID:
C0442811
Finding
20.

Prolonged

MedGen UID:
615082
Concept ID:
C0439590
Temporal Concept
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