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Germinoma

MedGen UID:
64626
Concept ID:
C0206660
Neoplastic Process
Synonyms: Germinomas
SNOMED CT: Germinoma (28307001)
 
HPO: HP:0100620
Orphanet: ORPHA182127

Definition

A malignant germ cell tumor arising in the central nervous system. It is characterized by the presence of primitive, large malignant germ cells and lymphocytes. [from NCI]

Recent clinical studies

Etiology

Fu H, Guo X, Li R, Xing B
J Clin Neurosci 2017 Sep;43:32-38. Epub 2017 Jun 8 doi: 10.1016/j.jocn.2017.05.024. PMID: 28602629
Yoneoka Y, Yoshimura J, Okada M, Fujii Y
Pediatr Neurosurg 2017;52(2):87-92. Epub 2016 Nov 11 doi: 10.1159/000450583. PMID: 27832656
Nikitović M, Grujičić D, Skender Gazibara M, Stanić D, Bokun J, Sarić M
World Neurosurg 2016 Nov;95:392-398. Epub 2016 Aug 20 doi: 10.1016/j.wneu.2016.08.039. PMID: 27554307
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2016 Oct;40(10):1417-23. doi: 10.1097/PAS.0000000000000704. PMID: 27454939
Fukuoka K, Yanagisawa T, Suzuki T, Shirahata M, Adachi JI, Mishima K, Fujimaki T, Katakami H, Matsutani M, Nishikawa R
J Neurosurg Pediatr 2016 Nov;18(5):573-577. Epub 2016 Jul 8 doi: 10.3171/2016.4.PEDS1658. PMID: 27391806

Diagnosis

Wang L, Zhu W, Li X, He J, Li C, Gong J
Childs Nerv Syst 2017 Nov;33(11):2039-2045. Epub 2017 Jul 8 doi: 10.1007/s00381-017-3502-2. PMID: 28689343
Scherz A, Feller K, Berezowska S, Genitsch V, Zweifel M
Anticancer Res 2017 Jun;37(6):3111-3115. doi: 10.21873/anticanres.11668. PMID: 28551652
Hu Q, Yu W, Du Q, Zhu Q, Che Z
Neurosurg Rev 2017 Jan;40(1):171-176. Epub 2016 Nov 7 doi: 10.1007/s10143-016-0793-9. PMID: 27822593
Nikitović M, Grujičić D, Skender Gazibara M, Stanić D, Bokun J, Sarić M
World Neurosurg 2016 Nov;95:392-398. Epub 2016 Aug 20 doi: 10.1016/j.wneu.2016.08.039. PMID: 27554307
Fukuoka K, Yanagisawa T, Suzuki T, Shirahata M, Adachi JI, Mishima K, Fujimaki T, Katakami H, Matsutani M, Nishikawa R
J Neurosurg Pediatr 2016 Nov;18(5):573-577. Epub 2016 Jul 8 doi: 10.3171/2016.4.PEDS1658. PMID: 27391806

Therapy

Fu H, Guo X, Li R, Xing B
J Clin Neurosci 2017 Sep;43:32-38. Epub 2017 Jun 8 doi: 10.1016/j.jocn.2017.05.024. PMID: 28602629
Scherz A, Feller K, Berezowska S, Genitsch V, Zweifel M
Anticancer Res 2017 Jun;37(6):3111-3115. doi: 10.21873/anticanres.11668. PMID: 28551652
Yoneoka Y, Yoshimura J, Okada M, Fujii Y
Pediatr Neurosurg 2017;52(2):87-92. Epub 2016 Nov 11 doi: 10.1159/000450583. PMID: 27832656
Strowd RE, Burger P, Holdhoff M, Kleinberg L, Okun MS, Olivi A, Pardo-Villamizar C, Schiess N
J Clin Neurosci 2015 May;22(5):911-3. Epub 2015 Mar 21 doi: 10.1016/j.jocn.2014.11.013. PMID: 25800941Free PMC Article
Saito R, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Mugikura S, Takahashi S, Tominaga T
J Clin Neurosci 2014 Jan;21(1):124-30. Epub 2013 Nov 12 doi: 10.1016/j.jocn.2013.05.014. PMID: 24238633

Prognosis

Wang L, Zhu W, Li X, He J, Li C, Gong J
Childs Nerv Syst 2017 Nov;33(11):2039-2045. Epub 2017 Jul 8 doi: 10.1007/s00381-017-3502-2. PMID: 28689343
Fu H, Guo X, Li R, Xing B
J Clin Neurosci 2017 Sep;43:32-38. Epub 2017 Jun 8 doi: 10.1016/j.jocn.2017.05.024. PMID: 28602629
Tajima S, Koda K
Med Mol Morphol 2017 Mar;50(1):52-58. Epub 2015 May 27 doi: 10.1007/s00795-015-0111-6. PMID: 26012485
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2016 Oct;40(10):1417-23. doi: 10.1097/PAS.0000000000000704. PMID: 27454939
Fukuoka K, Yanagisawa T, Suzuki T, Shirahata M, Adachi JI, Mishima K, Fujimaki T, Katakami H, Matsutani M, Nishikawa R
J Neurosurg Pediatr 2016 Nov;18(5):573-577. Epub 2016 Jul 8 doi: 10.3171/2016.4.PEDS1658. PMID: 27391806

Clinical prediction guides

Takano S, Yamamoto T, Ishikawa E, Akutsu H, Nakai K, Matsuda M, Muroi A, Shibata Y, Mizumoto M, Tsuboi K, Matsumura A
World Neurosurg 2015 Sep;84(3):846-54. Epub 2015 Jun 23 doi: 10.1016/j.wneu.2015.06.029. PMID: 26115804
Wataya T, Ishizaki R, Kitagawa M, Tashiro Y
Childs Nerv Syst 2015 Jun;31(6):953-8. Epub 2015 Jan 11 doi: 10.1007/s00381-015-2616-7. PMID: 25577220
Zhou ZH, Zhang HB, Rao J, Bian XW
J Craniofac Surg 2014 Sep;25(5):e467-70. doi: 10.1097/SCS.0000000000001056. PMID: 25148639
Wang R, Fan X, Zhang B
Spinal Cord 2014 Jun;52 Suppl 1:S19-22. doi: 10.1038/sc.2014.33. PMID: 24902643
Awa R, Campos F, Arita K, Sugiyama K, Tominaga A, Kurisu K, Yamasaki F, Karki P, Tokimura H, Fukukura Y, Fujii Y, Hanaya R, Oyoshi T, Hirano H
Neuroradiology 2014 Jul;56(7):525-34. Epub 2014 Apr 29 doi: 10.1007/s00234-014-1369-4. PMID: 24777305

Recent systematic reviews

Fu H, Guo X, Li R, Xing B
J Clin Neurosci 2017 Sep;43:32-38. Epub 2017 Jun 8 doi: 10.1016/j.jocn.2017.05.024. PMID: 28602629
Kilday JP, Laughlin S, Urbach S, Bouffet E, Bartels U
J Neurooncol 2015 Jan;121(1):167-75. Epub 2014 Sep 30 doi: 10.1007/s11060-014-1619-7. PMID: 25266413
Pedrazzoli P, Rosti G, Secondino S, Carminati O, Demirer T; European Group for Blood and Marrow Transplantation.; Solid Tumors Working Party.; Gruppo Italiano per il Trapianto di Midollo Osseo, Cellule Staminali Emopoietiche e Terapia Cellulare.
Semin Hematol 2007 Oct;44(4):286-95. doi: 10.1053/j.seminhematol.2007.08.009. PMID: 17961729
Vergouwe Y, Steyerberg EW, Eijkemans MJ, Albers P, Habbema JD
J Clin Oncol 2003 Nov 15;21(22):4092-9. Epub 2003 Oct 14 doi: 10.1200/JCO.2003.01.094. PMID: 14559885
Sa ki N, Tamaki K, Murai H, Kubota M, Yamaura A, Uchida D, Noguchi Y, Nakamura S, Tatsuno I, Wada K, Minagawa M, Yasuda T
Endocr J 2000 Feb;47(1):83-9. PMID: 10811297

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