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Undifferentiated Pleomorphic Sarcoma

MedGen UID:
87248
Concept ID:
C0334463
Neoplastic Process
Synonyms: Fibrohistiocytic Tumor, Malignant; Fibrohistiocytic Tumors, Malignant; Fibrous Histiocytoma, Malignant; Fibrous Histiocytomas, Malignant; Histiocytoma, Malignant Fibrous; Histiocytomas, Malignant Fibrous; Malignant Fibrohistiocytic Tumor; Malignant Fibrohistiocytic Tumors; Malignant Fibrous Histiocytoma; Malignant Fibrous Histiocytomas; Tumor, Malignant Fibrohistiocytic; Tumors, Malignant Fibrohistiocytic
Modes of inheritance:
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
not inherited (Orphanet)
SNOMED CT: Malignant fibrous histiocytoma (34360000); Malignant fibroxanthoma (34360000); Malignant fibrous histiocytoma (443439001); Undifferentiated high grade pleomorphic sarcoma (34360000); Fibrous histiocytoma, malignant (34360000); Fibroxanthoma, malignant (34360000)
 
Orphanet: ORPHA2023

Definition

An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma. [from NCI]

Recent clinical studies

Etiology

Hanlon A, Stasko T, Christiansen D, Cyrus N, Galan A
Dermatol Surg 2017 Mar;43(3):431-436. doi: 10.1097/DSS.0000000000001000. PMID: 28079637
Imanishi J, Slavin J, Pianta M, Jackett L, Ngan SY, Tanaka T, Charoenlap C, DI Bella C, Choong PF
Anticancer Res 2016 May;36(5):2339-44. PMID: 27127141
Toll A, Gimeno J, Baró T, Hernández-Muñoz MI, Pujol RM
Am J Dermatopathol 2016 Apr;38(4):270-7. doi: 10.1097/DAD.0000000000000396. PMID: 26999338
Di Marco J, Kaci R, Orcel P, Nizard R, Laredo JD
Cancer Radiother 2016 Feb;20(1):36-8. Epub 2015 Dec 22 doi: 10.1016/j.canrad.2015.06.021. PMID: 26725422
Ozcelik M, Seker M, Eraslan E, Koca S, Yazilitas D, Ercelep O, Ozaslan E, Kaya S, Hacibekiroglu I, Menekse S, Aksoy A, Taskoylu BY, Varol U, Arpaci E, Ciltas A, Oksuzoglu B, Zengin N, Gumus M, Aliustaoglu M
Tumour Biol 2016 Apr;37(4):5231-7. Epub 2015 Nov 10 doi: 10.1007/s13277-015-4359-1. PMID: 26553363

Diagnosis

Chen S, Fritchie K, Wei S, Ali N, Curless K, Shen T, Brini AT, Latif F, Sumathi V, Siegal GP, Cheng L
Hum Pathol 2017 Jul;65:239-246. Epub 2017 May 25 doi: 10.1016/j.humpath.2017.05.015. PMID: 28552826
Choi W, Hwang JH, Kim GE, Yoon KC
Medicine (Baltimore) 2017 May;96(18):e6616. doi: 10.1097/MD.0000000000006616. PMID: 28471957Free PMC Article
Osio A, Vignon-Pennamen MD, Pedeutour F, Le Maignan C, Koskas F, Lebbé C, Janin A, Battistella M
J Cutan Pathol 2017 May;44(5):477-479. Epub 2017 Feb 15 doi: 10.1111/cup.12907. PMID: 28105789
Bekki H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Otsuka H, Yamamoto H, Hakozaki M, Nabeshima K, Iwamoto Y, Oda Y
Pathobiology 2017;84(3):161-169. Epub 2016 Sep 22 doi: 10.1159/000448524. PMID: 27652596
Di Marco J, Kaci R, Orcel P, Nizard R, Laredo JD
Cancer Radiother 2016 Feb;20(1):36-8. Epub 2015 Dec 22 doi: 10.1016/j.canrad.2015.06.021. PMID: 26725422

Therapy

Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM
Anticancer Res 2017 Aug;37(8):4081-4084. doi: 10.21873/anticanres.11794. PMID: 28739691
Lee AY, Agaram NP, Qin LX, Kuk D, Curtin C, Brennan MF, Singer S
Ann Surg Oncol 2016 Mar;23(3):818-25. Epub 2016 Jan 12 doi: 10.1245/s10434-015-5063-5. PMID: 26759307Free PMC Article
Dineen SP, Roland CL, Feig R, May C, Zhou S, Demicco E, Sannaa GA, Ingram D, Wang WL, Ravi V, Guadagnolo A, Lev D, Pollock RE, Hunt K, Cormier J, Lazar A, Feig B, Torres KE
Ann Surg Oncol 2015 Nov;22(12):3913-20. Epub 2015 Mar 6 doi: 10.1245/s10434-015-4453-z. PMID: 25743327Free PMC Article
McCoppin HH, Christiansen D, Stasko T, Washington C, Martinez JC, Brown MD, Zwald FO
Dermatol Surg 2012 Feb;38(2):230-9. Epub 2011 Nov 30 doi: 10.1111/j.1524-4725.2011.02180.x. PMID: 22129349
Tsuchiya H, Takeuchi A, Yamamoto N, Shirai T, Hayashi K, Nishida H, Tomita K
J Orthop Sci 2011 Jul;16(4):476-81. Epub 2011 Apr 2 doi: 10.1007/s00776-011-0056-0. PMID: 21461725

Prognosis

Chen S, Fritchie K, Wei S, Ali N, Curless K, Shen T, Brini AT, Latif F, Sumathi V, Siegal GP, Cheng L
Hum Pathol 2017 Jul;65:239-246. Epub 2017 May 25 doi: 10.1016/j.humpath.2017.05.015. PMID: 28552826
Choi W, Hwang JH, Kim GE, Yoon KC
Medicine (Baltimore) 2017 May;96(18):e6616. doi: 10.1097/MD.0000000000006616. PMID: 28471957Free PMC Article
Bekki H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Otsuka H, Yamamoto H, Hakozaki M, Nabeshima K, Iwamoto Y, Oda Y
Pathobiology 2017;84(3):161-169. Epub 2016 Sep 22 doi: 10.1159/000448524. PMID: 27652596
Jeong CY, Kim CS
Ear Nose Throat J 2016 Dec;95(12):E12-E14. PMID: 27929601
Di Marco J, Kaci R, Orcel P, Nizard R, Laredo JD
Cancer Radiother 2016 Feb;20(1):36-8. Epub 2015 Dec 22 doi: 10.1016/j.canrad.2015.06.021. PMID: 26725422

Clinical prediction guides

Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM
Anticancer Res 2017 Aug;37(8):4081-4084. doi: 10.21873/anticanres.11794. PMID: 28739691
Chen S, Fritchie K, Wei S, Ali N, Curless K, Shen T, Brini AT, Latif F, Sumathi V, Siegal GP, Cheng L
Hum Pathol 2017 Jul;65:239-246. Epub 2017 May 25 doi: 10.1016/j.humpath.2017.05.015. PMID: 28552826
Choi W, Hwang JH, Kim GE, Yoon KC
Medicine (Baltimore) 2017 May;96(18):e6616. doi: 10.1097/MD.0000000000006616. PMID: 28471957Free PMC Article
Hanlon A, Stasko T, Christiansen D, Cyrus N, Galan A
Dermatol Surg 2017 Mar;43(3):431-436. doi: 10.1097/DSS.0000000000001000. PMID: 28079637
Ozcelik M, Seker M, Eraslan E, Koca S, Yazilitas D, Ercelep O, Ozaslan E, Kaya S, Hacibekiroglu I, Menekse S, Aksoy A, Taskoylu BY, Varol U, Arpaci E, Ciltas A, Oksuzoglu B, Zengin N, Gumus M, Aliustaoglu M
Tumour Biol 2016 Apr;37(4):5231-7. Epub 2015 Nov 10 doi: 10.1007/s13277-015-4359-1. PMID: 26553363

Recent systematic reviews

Kohlmeyer J, Steimle-Grauer SA, Hein R
J Dtsch Dermatol Ges 2017 Jun;15(6):630-648. doi: 10.1111/ddg.13249. PMID: 28591457
Kohlmeyer J, Steimle-Grauer SA, Hein R
J Dtsch Dermatol Ges 2017 Jun;15(6):630-649. doi: 10.1111/ddg.13249_g. PMID: 28591446
Trans-Atlantic RPS Working Group.
Ann Surg Oncol 2016 Oct;23(11):3531-3540. Epub 2016 Aug 1 doi: 10.1245/s10434-016-5336-7. PMID: 27480354Free PMC Article
Romeo S, Bovée JV, Kroon HM, Tirabosco R, Natali C, Zanatta L, Sciot R, Mertens F, Athanasou N, Alberghini M, Szuhai K, Hogendoorn PC, Dei Tos AP
Virchows Arch 2012 Nov;461(5):561-70. Epub 2012 Sep 22 doi: 10.1007/s00428-012-1306-z. PMID: 23001328

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