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Items: 3

1.

Melatonin

A hormone involved in sleep regulatory activity, and a tryptophan-derived neurotransmitter, which inhibits the synthesis and secretion of other neurotransmitters such as dopamine and GABA. Melatonin is synthesized from serotonin intermediate in the pineal gland and the retina where the enzyme 5-hydroxyindole-O-methyltransferase, that catalyzes the last step of synthesis, is found. This hormone binds to and activates melatonin receptors and is involved in regulating the sleep and wake cycles. In addition, melatonin possesses antioxidative and immunoregulatory properties via regulating other neurotransmitters. [from NCI]

MedGen UID:
44345
Concept ID:
C0025219
Hormone; Organic Chemical; Pharmacologic Substance
2.

His bundle tachycardia

His bundle tachycardia is a very rare congenital genetic tachyarrhythmia characterized by incessant tachycardia and high morbidity and mortality. [from ORDO]

MedGen UID:
832768
Concept ID:
CN204172
Finding
3.

Jet lag

A subtype of circadian rhythm sleep disorder in which the individual exhibits an endogenous pattern of sleep and wakefulness that comes into conflict with the pattern of sleep and wakefulness required by a new time zone. [from NCI]

MedGen UID:
115901
Concept ID:
C0231311
Disease or Syndrome
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