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Items: 1 to 20 of 75

1.

SK&F-100273

MedGen UID:
435845
Concept ID:
C2607866
Amino Acid, Peptide, or Protein; Pharmacologic Substance
2.

SK&F-82526

MedGen UID:
196543
Concept ID:
C0733626
Organic Chemical; Pharmacologic Substance
3.

SK&F-14287

MedGen UID:
196149
Concept ID:
C0701475
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
4.

SK&F-62979

MedGen UID:
196022
Concept ID:
C0700706
Organic Chemical; Pharmacologic Substance
5.

SK&F-92676

MedGen UID:
168010
Concept ID:
C0878322
Organic Chemical; Pharmacologic Substance
6.

SK&F-92058

MedGen UID:
163862
Concept ID:
C0878345
Organic Chemical; Pharmacologic Substance
7.

SK&F-104864-A

MedGen UID:
148681
Concept ID:
C0700912
Organic Chemical; Pharmacologic Substance
8.

SK&F-92334

MedGen UID:
148629
Concept ID:
C0700700
Organic Chemical; Pharmacologic Substance
9.

SK&F-18667

MedGen UID:
147519
Concept ID:
C0728932
Organic Chemical; Pharmacologic Substance
10.

SK&F-525-A

MedGen UID:
119429
Concept ID:
C0618948
Organic Chemical; Pharmacologic Substance
11.

SK&F-96356

MedGen UID:
58847
Concept ID:
C0168348
Organic Chemical; Pharmacologic Substance
12.

SK&F-105657

MedGen UID:
56918
Concept ID:
C0142484
Organic Chemical; Pharmacologic Substance
13.

SK&F-38393

MedGen UID:
20775
Concept ID:
C0037239
Organic Chemical; Pharmacologic Substance
14.

Abnormality of extrapyramidal motor function

A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless). [from HPO]

MedGen UID:
115941
Concept ID:
C0234133
Sign or Symptom
15.

Tardive dyskinesia

Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is estimated to occur in 20 to 30% of chronic schizophrenics on long-term treatment (Thelma et al., 2008). [from OMIM]

MedGen UID:
151939
Concept ID:
C0686347
Disease or Syndrome
16.

DNA Fragmentation

Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS. [from MeSH]

MedGen UID:
138244
Concept ID:
C0376669
Molecular Function
17.

AT 10

MedGen UID:
108470
Concept ID:
C0591126
Organic Chemical; Pharmacologic Substance
18.

Haloperidol

A drug used to treat certain mental and neurological disorders. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of antiemetic and a type of antipsychotic. [from NCI_NCI-GLOSS]

MedGen UID:
42327
Concept ID:
C0018546
Organic Chemical; Pharmacologic Substance
19.

Dopamine

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [from NCI]

MedGen UID:
41644
Concept ID:
C0013030
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
20.

Risperidone

A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA. [from MeSH]

MedGen UID:
34414
Concept ID:
C0073393
Organic Chemical; Pharmacologic Substance
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