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Items: 18

1.

DNA Methylation

The process by which methyl groups are added to nucleotides in genomic DNA. [from NCI]

MedGen UID:
138191
Concept ID:
C0376452
Molecular Function
2.

Folate

Class of water-soluble vitamins that are coenzymes in single-carbon transfers in the metabolism of nucleic and amino acids. (DRI) [from NCI_CRCH]

MedGen UID:
59819
Concept ID:
C0178638
Organic Chemical; Pharmacologic Substance; Vitamin
3.

5,10-methylenetetrahydrofolate

A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity. [from NCI]

MedGen UID:
59057
Concept ID:
C0048858
Organic Chemical; Pharmacologic Substance; Vitamin
4.

Methylation

The covalent chemical or biochemical addition of a methyl group(s) to a compound. (NCI) [from NCI]

MedGen UID:
44400
Concept ID:
C0025723
Molecular Function
5.

5-Methyltetrahydrofolate

MedGen UID:
59149
Concept ID:
C0049315
Organic Chemical; Pharmacologic Substance; Vitamin
6.

Methionine

a kind of amino acid [from CHV]

MedGen UID:
9989
Concept ID:
C0025646
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
7.

Liquid

MedGen UID:
725915
Concept ID:
C1304698
Finding
8.

Peripheral

On or near an edge or constituting an outer boundary; the outer area. (NCI) [from NCI_CDISC]

MedGen UID:
59959
Concept ID:
C0205100
Spatial Concept
9.

Coronary artery disease

Coronary artery disease (CAD) is the most common type of heart disease. It is the leading cause of death in the United States in both men and women. CAD happens when the arteries that supply blood to heart muscle become hardened and narrowed. This is due to the buildup of cholesterol and other material, called plaque, on their inner walls. This buildup is called atherosclerosis. As it grows, less blood can flow through the arteries. As a result, the heart muscle can't get the blood or oxygen it needs. This can lead to chest pain (angina) or a heart attack. Most heart attacks happen when a blood clot suddenly cuts off the hearts' blood supply, causing permanent heart damage. . Over time, CAD can also weaken the heart muscle and contribute to heart failure and arrhythmias. Heart failure means the heart can't pump blood well to the rest of the body. Arrhythmias are changes in the normal beating rhythm of the heart. . NIH: National Heart, Lung, and Blood Institute.  [from MedlinePlus]

MedGen UID:
365486
Concept ID:
C1956346
Disease or Syndrome
10.

Folacin

folate and its derivatives. [from CRISP]

MedGen UID:
152036
Concept ID:
C0699376
Organic Chemical; Pharmacologic Substance; Vitamin
11.

Myocardial Ischemia

blood deficiency in the myocardium caused by a constriction or obstruction of its blood vessels; frequently occurs in conjunction with hypoxia, which is reduction in oxygen supply. [from CRISP]

MedGen UID:
101801
Concept ID:
C0151744
Disease or Syndrome
12.

Vascular disorder

The vascular system is the body's network of blood vessels. It includes the arteries, veins and capillaries that carry blood to and from the heart. Problems of the vascular system are common and can be serious. Arteries can become thick and stiff, a problem called atherosclerosis. Blood clots can clog vessels and block blood flow to the heart or brain. Weakened blood vessels can burst, causing bleeding inside the body. . You are more likely to have vascular disease as you get older. Other factors that make vascular disease more likely include. - Family history of vascular or heart diseases. - Pregnancy. - Illness or injury . - Long periods of sitting or standing still. - Any condition that affects the heart and blood vessels, such as diabetes or high cholesterol . - Smoking . - Obesity . Losing weight, eating healthy foods, being active and not smoking can help vascular disease. Other treatments include medicines and surgery.  [from MedlinePlus]

MedGen UID:
22621
Concept ID:
C0042373
Disease or Syndrome
13.

Peripheral artery occlusive disease

A narrowing of the peripheral arteries (i.e., of arteries other than thos that supply the heart and the brain). [from HPO]

MedGen UID:
13913
Concept ID:
C0003838
Disease or Syndrome
14.

Folic Acid

Folic acid is a B vitamin. It helps the body make healthy new cells. Everyone needs folic acid. For women who may get pregnant, it is really important. Getting enough folic acid before and during pregnancy can prevent major birth defects of her baby's brain or spine. . Foods with folic acid in them include. -Leafy green vegetables. -Fruits. -Dried beans, peas, and nuts. -Enriched breads, cereals and other grain products. If you don't get enough folic acid from the foods you eat, you can also take it as a dietary supplement. NIH: National Institutes of Health Office of Dietary Supplements.  [from MedlinePlus]

MedGen UID:
8876
Concept ID:
C0016410
Organic Chemical; Pharmacologic Substance; Vitamin
15.

Heart disease

If you're like most people, you think that heart disease is a problem for others. But heart disease is the number one killer in the U.S. It is also a major cause of disability. There are many different forms of heart disease. The most common cause of heart disease is narrowing or blockage of the coronary arteries, the blood vessels that supply blood to the heart itself. This is called coronary artery disease and happens slowly over time. It's the major reason people have heart attacks. Other kinds of heart problems may happen to the valves in the heart, or the heart may not pump well and cause heart failure. Some people are born with heart disease. You can help reduce your risk of heart disease by taking steps to control factors that put you at greater risk:. - Control your blood pressure. - Lower your cholesterol. - Don't smoke. - Get enough exercise. NIH: National Heart, Lung, and Blood Institute.  [from MedlinePlus]

MedGen UID:
5458
Concept ID:
C0018799
Disease or Syndrome
16.

Coronary heart disease

An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. [from MeSH]

MedGen UID:
3624
Concept ID:
C0010068
Disease or Syndrome
17.

Disorder of cardiovascular system

Any abnormality of the cardiovascular system. [from HPO]

MedGen UID:
2848
Concept ID:
C0007222
Disease or Syndrome
18.

Arteriosclerosis

Sclerosis (hardening) of the arteries with increased thickness of the wall of arteries as well as increased stiffness and a loss of elasticity. [from HPO]

MedGen UID:
2076
Concept ID:
C0003850
Disease or Syndrome
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