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ATP Hydrolysis

MedGen UID:
266945
Concept ID:
C1510699
Molecular Function
 

Definition

ATP Hydrolysis is the cleavage of a high-energy phosphate bond of adenosine triphosphate by the addition of water. The energy derived from hydrolysis of ATP is used to drive metabolic reactions including nucleic acid and protein synthesis, to move molecules against concentration gradients (active transport), and to produce mechanical motion (contraction of microfibrils and microtubules). [from NCI]

Recent clinical studies

Etiology

Davis W Jr
Biochim Biophys Acta 2014 Jan;1841(1):168-79. Epub 2013 Nov 5 doi: 10.1016/j.bbalip.2013.10.019. PMID: 24201375Free PMC Article
Jardim-Messeder D, Camacho-Pereira J, Galina A
Int J Biochem Cell Biol 2012 May;44(5):801-7. Epub 2012 Feb 17 doi: 10.1016/j.biocel.2012.02.002. PMID: 22343412
Jun B, Kim S
J Biol Chem 2010 Apr 9;285(15):11073-7. Epub 2010 Feb 12 doi: 10.1074/jbc.C110.103762. PMID: 20154092Free PMC Article
Lee DY, Park SJ, Jeong W, Sung HJ, Oho T, Wu X, Rhee SG, Gruschus JM
Biochemistry 2006 Dec 26;45(51):15301-9. Epub 2006 Dec 5 doi: 10.1021/bi061824h. PMID: 17176052
Hu Y, Benedict MA, Ding L, Núñez G
EMBO J 1999 Jul 1;18(13):3586-95. doi: 10.1093/emboj/18.13.3586. PMID: 10393175Free PMC Article

Diagnosis

Epling LB, Grace CR, Lowe BR, Partridge JF, Enemark EJ
J Mol Biol 2015 May 8;427(9):1779-1796. Epub 2015 Feb 25 doi: 10.1016/j.jmb.2015.02.015. PMID: 25724843Free PMC Article
Loo TW, Bartlett MC, Clarke DM
Biochemistry 2007 Aug 14;46(32):9328-36. Epub 2007 Jul 18 doi: 10.1021/bi700837y. PMID: 17636884
Smith CL, Peterson CL
Mol Cell Biol 2005 Jul;25(14):5880-92. doi: 10.1128/MCB.25.14.5880-5892.2005. PMID: 15988005Free PMC Article
Sauna ZE, Nandigama K, Ambudkar SV
J Biol Chem 2004 Nov 19;279(47):48855-64. Epub 2004 Sep 9 doi: 10.1074/jbc.M408849200. PMID: 15364914
Yang R, Cui L, Hou YX, Riordan JR, Chang XB
J Biol Chem 2003 Aug 15;278(33):30764-71. Epub 2003 Jun 3 doi: 10.1074/jbc.M304118200. PMID: 12783859

Therapy

Hawley JA, Leckey JJ
Sports Med 2015 Nov;45 Suppl 1:S5-12. doi: 10.1007/s40279-015-0400-1. PMID: 26553495Free PMC Article
Peterson JR, De La Rosa S, Eboda O, Cilwa KE, Agarwal S, Buchman SR, Cederna PS, Xi C, Morris MD, Herndon DN, Xiao W, Tompkins RG, Krebsbach PH, Wang SC, Levi B
Sci Transl Med 2014 Sep 24;6(255):255ra132. doi: 10.1126/scitranslmed.3008810. PMID: 25253675Free PMC Article
Stukalin EB, Kolomeisky AB
Biophys J 2006 Apr 15;90(8):2673-85. Epub 2006 Jan 27 doi: 10.1529/biophysj.105.074211. PMID: 16443647Free PMC Article
Sauna ZE, Ambudkar SV
J Biol Chem 2001 Apr 13;276(15):11653-61. Epub 2001 Jan 11 doi: 10.1074/jbc.M011294200. PMID: 11154703
Steel GJ, Harley C, Boyd A, Morgan A
Mol Biol Cell 2000 Apr;11(4):1345-56. PMID: 10749934Free PMC Article

Prognosis

Nagao K, Takahashi K, Azuma Y, Takada M, Kimura Y, Matsuo M, Kioka N, Ueda K
J Lipid Res 2012 Jan;53(1):126-36. Epub 2011 Oct 25 doi: 10.1194/jlr.M019976. PMID: 22028339Free PMC Article
Stukalin EB, Kolomeisky AB
Biophys J 2006 Apr 15;90(8):2673-85. Epub 2006 Jan 27 doi: 10.1529/biophysj.105.074211. PMID: 16443647Free PMC Article
Wackerhage H, Hoffmann U, Essfeld D, Leyk D, Mueller K, Zange J
J Appl Physiol (1985) 1998 Dec;85(6):2140-5. PMID: 9843537
Hrycyna CA, Airan LE, Germann UA, Ambudkar SV, Pastan I, Gottesman MM
Biochemistry 1998 Sep 29;37(39):13660-73. doi: 10.1021/bi9808823. PMID: 9753453
Ishihara H, Welsh MJ
Am J Physiol 1997 Oct;273(4 Pt 1):C1278-89. PMID: 9357772

Clinical prediction guides

Belknap B, Harris SP, White HD
Biochemistry 2014 Oct 28;53(42):6717-24. Epub 2014 Oct 20 doi: 10.1021/bi500787f. PMID: 25265574Free PMC Article
Jih KY, Hwang TC
Proc Natl Acad Sci U S A 2013 Mar 12;110(11):4404-9. Epub 2013 Feb 25 doi: 10.1073/pnas.1215982110. PMID: 23440202Free PMC Article
Jardim-Messeder D, Camacho-Pereira J, Galina A
Int J Biochem Cell Biol 2012 May;44(5):801-7. Epub 2012 Feb 17 doi: 10.1016/j.biocel.2012.02.002. PMID: 22343412
Nagao K, Takahashi K, Azuma Y, Takada M, Kimura Y, Matsuo M, Kioka N, Ueda K
J Lipid Res 2012 Jan;53(1):126-36. Epub 2011 Oct 25 doi: 10.1194/jlr.M019976. PMID: 22028339Free PMC Article
Krzysiak TC, Gilbert SP
J Biol Chem 2006 Dec 22;281(51):39444-54. Epub 2006 Oct 23 doi: 10.1074/jbc.M608056200. PMID: 17062577Free PMC Article

Recent systematic reviews

Luan J, Chu Z, Chandra J, Zhang P
Curr Protein Pept Sci 2016;17(5):455-62. PMID: 26796303
Oudman I, Clark JF, Brewster LM
PLoS One 2013;8(1):e52879. Epub 2013 Jan 9 doi: 10.1371/journal.pone.0052879. PMID: 23326362Free PMC Article
Shukla S, Ohnuma S, Ambudkar SV
Curr Drug Targets 2011 May;12(5):621-30. PMID: 21039338Free PMC Article
Yarmola EG, Dranishnikov DA, Bubb MR
Biophys J 2008 Dec 15;95(12):5544-73. Epub 2008 Oct 3 doi: 10.1529/biophysj.108.134569. PMID: 18835900Free PMC Article

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