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Items: 1 to 20 of 54

1.

Acute myeloid leukemia

CEBPA-associated familial acute myeloid leukemia (AML) is defined as AML in which a heterozygous germline CEBPA pathogenic variant is present in a family in which multiple individuals have AML. In contrast, sporadic CEBPA-associated AML is defined as AML in which a CEBPA pathogenic variant(s) is identified in leukemic cells but not in the non-leukemic cells. Too few individuals with CEBPA-associated familial AML have been reported to be certain about the natural history of the disease. In the majority of individuals, the age of onset of familial AML appears to be earlier than sporadic AML; disease onset has been reported in persons as young as age 1.8 years and older than age 45 years. The prognosis of CEBPA-associated familial AML appears to be favorable compared with sporadic CEBPA-associated AML. Individuals with CEBPA-associated familial AML who have been cured of their initial disease may be at greater risk of developing additional independent leukemic episodes in addition to the risk of relapse due to preexisting clones. [from GTR]

MedGen UID:
9730
Concept ID:
C0023467
Neoplastic Process
2.

Acute myeloid leukemia, M6 type

Familial erythroleukemia is a leukemic or preleukemic state in which red cell proliferation is the predominant feature. Hematologic characteristics include particularly ineffective and hyperplastic erythropoiesis with megaloblastic components accompanied by myeloblastic proliferation of varying degree (Park et al., 2002). Park et al. (2002) discussed the evolution of the definition of 'erythroleukemia,' which is considered by most to be a subtype of acute myelogenous leukemia (AML; 601626). Controversy about the precise definition of erythroleukemia revolves around the number or percentage of erythroblasts and myeloblasts found in the bone marrow and peripheral circulation. In the French-American-British (FAB) classification system (Bennett et al., 1985), it is known as AML-M6, whereas in the revised World Health Organization (WHO) classification system (Harris et al., 1999), it is known as 'AML, not otherwise categorized' (Zini and D'Onofrio, 2004). [from GTR]

MedGen UID:
7316
Concept ID:
C0023440
Neoplastic Process
3.

Acute Basophilic Leukemia

A rare acute myeloid leukemia in which the immature cells differentiate towards basophils. [from NCI]

MedGen UID:
7314
Concept ID:
C0023437
Neoplastic Process
4.

Acute erythroleukemia

MedGen UID:
443946
Concept ID:
C2930974
Disease or Syndrome
5.

Iron agent

A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. [from MeSH]

MedGen UID:
137068
Concept ID:
C0302583
Biologically Active Substance; Element, Ion, or Isotope; Pharmacologic Substance
6.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [from HPO]

MedGen UID:
9725
Concept ID:
C0023418
Neoplastic Process
7.

Myeloid leukemia

A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia. [from NCI]

MedGen UID:
7320
Concept ID:
C0023470
Neoplastic Process
8.

Gigantism

A clinical finding indicating abnormal and excessive body growth and height resulting from the overproduction of human growth hormone. [from NCI]

MedGen UID:
6602
Concept ID:
C0017547
Disease or Syndrome
9.

Blood platelet disease

An abnormality of platelets. [from HPO]

MedGen UID:
893128
Concept ID:
C4020863
Disease or Syndrome
10.

Schistocytosis

The presence of an abnormal number of fragmented red blood cells (schistocytes) in the blood. [from HPO]

MedGen UID:
576247
Concept ID:
C0344386
Laboratory or Test Result
11.

Basophilic stippling

MedGen UID:
569400
Concept ID:
C0333812
Finding
12.

Acute myeloid leukemia

A form of leukemia characterized by overproduction of an early myeloid cell. [from HPO]

MedGen UID:
505691
Concept ID:
CN004254
Finding
13.

Complex Karyotype

Karyotype with at least three chromosomal aberrations. [from NCI]

MedGen UID:
474886
Concept ID:
C3273253
Cell or Molecular Dysfunction
14.

History

The aggregate of past events; the continuum of events occurring in succession leading from the past to the present; a record or narrative description of past events. [from NCI]

MedGen UID:
389153
Concept ID:
C2004062
Finding
15.

Acute erythroid leukemia

MedGen UID:
377038
Concept ID:
C1851482
Neoplastic Process
16.

Karyorrhexis

Degeneration of the cell nucleus marked by contraction of the chromatin into small pieces and loss of the nuclear boundary. [from NCI]

MedGen UID:
137694
Concept ID:
C0333732
Cell or Molecular Dysfunction
17.

Dysplasia

A usually neoplastic transformation of the cell, associated with altered architectural tissue patterns. The cellular changes include nuclear and cytoplasmic abnormalities. Molecular genetic abnormalities are also often found and, in some instances, may lead to cancer. [from NCI]

MedGen UID:
87191
Concept ID:
C0334044
Pathologic Function
18.

Frequent

Coming at short intervals or in great quantities. [from NCI]

MedGen UID:
87144
Concept ID:
C0332183
Temporal Concept
19.

Acute

Sudden appearance of disease manifestations over a short period of time. [from HPO]

MedGen UID:
61381
Concept ID:
C0205178
Temporal Concept
20.

Peripheral

On or near an edge or constituting an outer boundary; the outer area. [from NCI]

MedGen UID:
59959
Concept ID:
C0205100
Spatial Concept
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