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Organic brain syndrome

MedGen UID:
45219
Concept ID:
C0029221
Disease or Syndrome
Synonyms: OBS - Organic brain syndrome; Organic Brain Syndrome
SNOMED CT: Organic brain syndrome (2776000); OBS - Organic brain syndrome (2776000)
 

Definition

A mental disorder caused by intrinsic disease which is characterized by acute or chronic impairment of intellectual functioning, behavior, mood or judgment. It is attributable to a medical etiology and excludes a primary psychiatric cause. A chronic course usually correlates to a poorer prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrganic brain syndrome

Recent clinical studies

Etiology

Eriksson M, Samuelsson E, Gustafson Y, Aberg T, Engström KG
Scand Cardiovasc J 2002 Aug;36(4):250-5. doi: 10.1080/14017430260180436. PMID: 12201975
Grekin ER, Brennan PA, Hodgins S, Mednick SA
Am J Psychiatry 2001 Jul;158(7):1099-104. doi: 10.1176/appi.ajp.158.7.1099. PMID: 11431232
Kanowski S, Kinzler E, Lehmann E, Schweizer A, Kuntz G
Pharmacopsychiatry 1995 Jul;28(4):125-33. doi: 10.1055/s-2007-979604. PMID: 7491366
Hjorther A, Browne E, Jakobsen K, Viskum P, Gyntelberg F
Acta Neurol Scand 1987 Apr;75(4):271-6. PMID: 3296624
Joborn C, Hetta J, Frisk P, Palmér M, Akerström G, Ljunghall S
Acta Med Scand 1986;219(1):91-8. PMID: 3953319

Diagnosis

Shinno H, Hikasa S, Matsuoka T, Fujita H, Yamamoto O, Takebayashi M, Uchida Y, Nishiura T, Horiguchi J
Gen Hosp Psychiatry 2006 Sep-Oct;28(5):455-7. doi: 10.1016/j.genhosppsych.2006.06.003. PMID: 16950388
Kato T, Shiratori K, Kobashigawa T, Hidaka Y
Intern Med 2006;45(2):95-9. Epub 2006 Feb 15 PMID: 16484747
Björkelund KB, Larsson S, Gustafson L, Andersson E
Int J Geriatr Psychiatry 2006 Mar;21(3):210-22. doi: 10.1002/gps.1449. PMID: 16440405
Eriksson M, Samuelsson E, Gustafson Y, Aberg T, Engström KG
Scand Cardiovasc J 2002 Aug;36(4):250-5. doi: 10.1080/14017430260180436. PMID: 12201975
Grekin ER, Brennan PA, Hodgins S, Mednick SA
Am J Psychiatry 2001 Jul;158(7):1099-104. doi: 10.1176/appi.ajp.158.7.1099. PMID: 11431232

Therapy

Shinno H, Hikasa S, Matsuoka T, Fujita H, Yamamoto O, Takebayashi M, Uchida Y, Nishiura T, Horiguchi J
Gen Hosp Psychiatry 2006 Sep-Oct;28(5):455-7. doi: 10.1016/j.genhosppsych.2006.06.003. PMID: 16950388
Kato T, Shiratori K, Kobashigawa T, Hidaka Y
Intern Med 2006;45(2):95-9. Epub 2006 Feb 15 PMID: 16484747
Eriksson M, Samuelsson E, Gustafson Y, Aberg T, Engström KG
Scand Cardiovasc J 2002 Aug;36(4):250-5. doi: 10.1080/14017430260180436. PMID: 12201975
Grekin ER, Brennan PA, Hodgins S, Mednick SA
Am J Psychiatry 2001 Jul;158(7):1099-104. doi: 10.1176/appi.ajp.158.7.1099. PMID: 11431232
Kanowski S, Kinzler E, Lehmann E, Schweizer A, Kuntz G
Pharmacopsychiatry 1995 Jul;28(4):125-33. doi: 10.1055/s-2007-979604. PMID: 7491366

Prognosis

Spagnoli A, Foresti G, MacDonald A, Williams P
Psychol Med 1987 May;17(2):507-13. PMID: 3602241
Joborn C, Hetta J, Frisk P, Palmér M, Akerström G, Ljunghall S
Acta Med Scand 1986;219(1):91-8. PMID: 3953319
Saletu B, Saletu M, Grünberger J, Mader R
Psychiatry Res 1983 Sep;10(1):59-75. PMID: 6580659
Gaitz CM, Varner RV, Overall JE
Arch Gen Psychiatry 1977 Jul;34(7):839-45. PMID: 406875
Sperber MA
Biol Psychiatry 1975 Feb;10(1):27-43. PMID: 1120174

Clinical prediction guides

Shinno H, Hikasa S, Matsuoka T, Fujita H, Yamamoto O, Takebayashi M, Uchida Y, Nishiura T, Horiguchi J
Gen Hosp Psychiatry 2006 Sep-Oct;28(5):455-7. doi: 10.1016/j.genhosppsych.2006.06.003. PMID: 16950388
Kanowski S, Kinzler E, Lehmann E, Schweizer A, Kuntz G
Pharmacopsychiatry 1995 Jul;28(4):125-33. doi: 10.1055/s-2007-979604. PMID: 7491366
Stapleton JM, Eckardt MJ, Martin P, Adinoff B, Roehrich L, Bone G, Rubinow D, Linnoila M
Adv Alcohol Subst Abuse 1988;7(3-4):47-51. doi: 10.1300/J251v07n03_08. PMID: 2464912
Hjorther A, Browne E, Jakobsen K, Viskum P, Gyntelberg F
Acta Neurol Scand 1987 Apr;75(4):271-6. PMID: 3296624
Saletu B, Saletu M, Grünberger J, Mader R
Psychiatry Res 1983 Sep;10(1):59-75. PMID: 6580659

Recent systematic reviews

Trevisani VF, Castro AA, Neves Neto JF, Atallah AN
Cochrane Database Syst Rev 2006 Apr 19;(2):CD002265. doi: 10.1002/14651858.CD002265.pub2. PMID: 16625558
Björkelund KB, Larsson S, Gustafson L, Andersson E
Int J Geriatr Psychiatry 2006 Mar;21(3):210-22. doi: 10.1002/gps.1449. PMID: 16440405
Trevisani VF, Castro AA, Neves Neto JF, Atallah AN
Cochrane Database Syst Rev 2000;(3):CD002265. doi: 10.1002/14651858.CD002265. PMID: 10908541
Fava M
Psychiatr Clin North Am 1997 Jun;20(2):427-51. PMID: 9196923
Smith DA, Perry PJ
Ann Pharmacother 1992 Nov;26(11):1400-8. doi: 10.1177/106002809202601114. PMID: 1362095

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