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Items: 9

1.

Receptor Binding

Receptor Binding involves a temporary non-covalent, typically highly specific and high affinity, interaction through intermolecular physical forces of attraction and spatial complementarity with a diverse group of intrinsic membrane or cytoplasmic proteins that mediate the biological effects of secreted regulatory signaling molecules through modification of the activity of signal transduction pathways. [from NCI]

MedGen UID:
154572
Concept ID:
C0597358
Molecular Function
2.

Nulojix

MedGen UID:
469016
Concept ID:
C3160359
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
3.

Abatacept

A fusion protein immunoconjugate of the extracellular domain of CTLA4 and the Fc domain of human IgG1. It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of T-LYMPHOCYTES. It is used in the treatment of RHEUMATOID ARTHRITIS. [from MeSH]

MedGen UID:
346383
Concept ID:
C1619966
Amino Acid, Peptide, or Protein; Pharmacologic Substance
4.

MDX-CTLA4

MedGen UID:
305578
Concept ID:
C1691227
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
5.

Belatacept

MedGen UID:
301872
Concept ID:
C1619962
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
6.

LEA 29Y

MedGen UID:
207423
Concept ID:
C1120969
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
7.

Sequence Deletion

Deletion of sequences of nucleic acids from the genetic material of an individual. [from MeSH]

MedGen UID:
102460
Concept ID:
C0162773
Cell or Molecular Dysfunction
8.

Immunoconjugate

An agent that consists of an immune substance, such as a monoclonal antibody, antigen or an immunoglobulin, and covalently bound to other molecule(s), usually either a toxin, a radioisotope, or a cytotoxic agent. Immunoconjugates allow for specific delivery of certain substances to specific cells or tissues for diagnostic or therapeutic purposes. [from NCI]

MedGen UID:
66203
Concept ID:
C0243020
Immunologic Factor; Pharmacologic Substance
9.

Radioimmunoconjugate

Monoclonal antibodies (MoAb) conjugated with radioisotopes, i.e., I-131, Y-90, T-99, or In-111. Using radioimmunoconjugates in radiotherapy or radioimaging has the advantage of targeting cells carrying specific antigens, thereby limiting toxic effects on normal cells. Tumor eradication can be achieved by either the antibody-mediated immune response or by only the cytotoxic activity of the radiation. [from NCI]

MedGen UID:
66202
Concept ID:
C0243019
Immunologic Factor; Pharmacologic Substance
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