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Items: 6

1.

Blood transfusion reaction

Complications of BLOOD TRANSFUSION. [from MeSH]

MedGen UID:
452371
Concept ID:
C0274435
Pathologic Function
2.

Hb SS disease

Sickle cell disease (SCD) is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia. Vaso-occlusive events result in tissue ischemia leading to acute and chronic pain as well as organ damage that can affect any organ system, including the bones, spleen, liver, brain, lungs, kidneys, and joints. Dactylitis (pain and/or swelling of the hands or feet) is often the earliest manifestation of SCD. In children, the spleen can become engorged with blood cells in a “splenic sequestration.” The spleen is particularly vulnerable to infarction and the majority of individuals with SCD who are not on hydroxyurea or transfusion therapy become functionally asplenic in early childhood, increasing their risk for certain types of bacterial infections. Acute chest syndrome is a major cause of mortality in SCD. Chronic hemolysis can result in varying degrees of anemia, jaundice, cholelithiasis, and delayed growth and sexual maturation. Individuals with the highest rates of hemolysis are predisposed to pulmonary artery hypertension, priapism, and leg ulcers but may be relatively protected from vaso-occlusive pain. [from GTR]

MedGen UID:
287
Concept ID:
C0002895
Disease or Syndrome
3.

Erythroid hyperplasia

Increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. [from HPO]

MedGen UID:
765831
Concept ID:
C3552917
Finding
4.

Hemolytic transfusion reaction

MedGen UID:
526155
Concept ID:
C0221123
Pathologic Function
5.

Reticulocytopenia

A reduced number of reticulocytes in the peripheral blood. [from HPO]

MedGen UID:
167812
Concept ID:
C0858867
Finding
6.

Erythroid hyperplasia

Increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. [from HPO]

MedGen UID:
4536
Concept ID:
C0014800
Disease or Syndrome
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