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Items: 1 to 20 of 23

1.

Patent ductus arteriosus

MedGen UID:
504886
Concept ID:
CN001496
Finding
2.

Patent ductus arteriosus

MedGen UID:
4415
Concept ID:
C0013274
Congenital Abnormality
3.

Vessel

MedGen UID:
56099
Concept ID:
C0148346
Organic Chemical; Pharmacologic Substance
4.

Prostaglandin

A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes. [from MeSH]

MedGen UID:
18692
Concept ID:
C0033554
Hormone; Organic Chemical; Pharmacologic Substance
5.

Absence

MedGen UID:
739164
Concept ID:
C1689985
Anatomical Abnormality
6.

Congenital premature fusion

Fusion, stoppage, or loss of patency occuring before the usual or proper time. [from NCI]

MedGen UID:
568682
Concept ID:
C0332877
Congenital Abnormality
7.

Abnormality of the cardiovascular system

MedGen UID:
116727
Concept ID:
C0243050
Congenital Abnormality
8.

Heart, malformation of

MedGen UID:
6748
Concept ID:
C0018798
Congenital Abnormality
9.

Heart disease

MedGen UID:
5458
Concept ID:
C0018799
Disease or Syndrome
10.

Disorder of cardiovascular system

MedGen UID:
2848
Concept ID:
C0007222
Disease or Syndrome
11.

Developmental abnormality

Any abnormality, anatomical or biochemical, evident at birth or during the neonatal period. [from NCI]

MedGen UID:
1254
Concept ID:
C0000768
Congenital Abnormality
12.

Patent Ductus Arteriosus Familial

MedGen UID:
424674
Concept ID:
C2936170
Congenital Abnormality
13.

Patent ductus arteriosus 3

The ductus arteriosus is a vital in utero vascular connection between the aorta and pulmonary artery that allows right ventricular output to bypass the nonventilated fetal lungs. Postnatal closure of the ductus arteriosus is an important step in normal cardiopulmonary transition. Failure of ductal closure results in patent ductus arteriosus (PDA), which occurs in approximately 2 to 8 per 10,000 term infants and constitutes 5% to 7% of all congenital heart defects (summary by Hajj and Dagle, 2012). For a discussion of genetic heterogeneity of isolated PDA, see PDA1 (607411). [from OMIM]

MedGen UID:
934720
Concept ID:
C4310753
Congenital Abnormality
14.

Patent ductus arteriosus 1

Persistent patency of the ductus arteriosus, or patent ductus arteriosus (PDA), is the second most common congenital heart disease, affecting approximately 1 in 1,600 to 5,000 live births in the U.S. (Mitchell et al., 1971). In fetal life, the ductus arteriosus, a muscular artery, shunts blood from the pulmonary artery to the aorta, bypassing the lungs. Its abrupt closure at birth establishes the mature circulatory pattern and represents a dramatic example of vascular remodeling. Failure of this normal process results in persistent PDA, which left untreated can result in pulmonary hypertension and heart failure. Closure of the ductus is a complex process. Aspects of this process are regulated by oxygen tension and a decrease in levels of hormones such as prostaglandin E2. PDA occurring in preterm infants often closes spontaneously or in response to inhibitors of prostaglandin biosynthesis (Ramsay et al., 1987). Term PDA typically has not been regarded as a genetic disorder, because it most often occurs sporadically. Nonetheless, term PDA recurs among 5% of sibs of PDA cases (Polani and Campbell, 1960; Lamy et al., 1957), suggesting a genetic component to disease pathogenesis that has typically been presumed to be multifactorial. That single genes can influence this trait has been demonstrated by a mouse model of PDA resulting from disruption of the prostaglandin E2 receptor (Nguyen et al., 1997) and by rare syndromic forms of PDA such as Char syndrome (169100), an autosomal dominant disorder caused by mutations in the transcription factor TFAP2B (601601) (Mani et al., 2002). Genetic Heterogeneity of Patent Ductus Arteriosus Autosomal dominant forms of patent ductus arteriosus include PDA2 (617035), caused by mutation in the TFAP2B gene (601601) on chromosome 6p12, and PDA3 (617039), caused by mutation in the PRDM6 gene (616982) on chromosome 5q23. Hajj and Dagle (2012) reviewed the genetics of patent ductus arteriosus in both term and preterm infants, and discussed possible environmental risk factors as well as animal models of PDA. [from OMIM]

MedGen UID:
924232
Concept ID:
C4282128
Congenital Abnormality
15.

Premature closure of the arterial duct

MedGen UID:
831678
Concept ID:
CN227700
Finding
16.

Closure of fetal arterial duct

MedGen UID:
759377
Concept ID:
C3532264
Finding
17.

Cardiovascular abnormality due to patent arterial duct

MedGen UID:
759170
Concept ID:
C3532057
Disease or Syndrome
18.

Arterial duct dependent pulmonary circulation

MedGen UID:
759126
Concept ID:
C3532012
Finding
19.

Dead fetus in utero

MedGen UID:
753758
Concept ID:
C2919450
Finding
20.

Congenital abnormality of arterial duct

MedGen UID:
657790
Concept ID:
C0574069
Congenital Abnormality
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