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Items: 9

1.

Fluoxetine

The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. [from MeSH]

MedGen UID:
42053
Concept ID:
C0016365
Organic Chemical; Pharmacologic Substance
2.

Depression

A melancholy feeling of sadness and despair. [from NCI]

MedGen UID:
8325
Concept ID:
C0011570
Mental or Behavioral Dysfunction
3.

Anxiety

Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus. [from NCI]

MedGen UID:
1613
Concept ID:
C0003467
Finding; Finding
4.

Clonazepam

A synthetic benzodiazepine derivative used for myotonic or atonic seizures, absence seizures, and photosensitive epilepsy, anticonvulsant Clonazepam appears to enhance gamma-aminobutyric acid receptor responses, although its mechanism of action is not clearly understood. It is seldom effective in generalized tonic-clonic or partial seizures. (NCI04) [from NCI]

MedGen UID:
1005
Concept ID:
C0009011
Organic Chemical; Pharmacologic Substance
5.

Anxiety

Human personality is shaped by genetic and environmental factors, and evidence suggests that the genetic component is highly complex, polygenic, and epistatic. Genetic factors are thought to contribute to 40 to 60% of trait variance. Molecular genetics has tried to identify specific genes for quantitative traits, called quantitative trait loci (QTLs). The QTL concept suggests that complex personality traits or dimensions are not attributable to single genes, but to multiple interacting genes (Reif and Lesch, 2003). Fullerton et al. (2003) stated that psychologists were in agreement that the wide variation in human personalities can be explained by a small number of personality factors, including neuroticism (a measure of emotional stability), which manifests at one extreme as anxiety, depression, moodiness, low self-esteem, and diffidence. They cited a number of studies that had described a relationship between high scores on measures of neuroticism and major depressive disorder. They also noted that theoretical studies had suggested that large samples of randomly ascertained sibs could be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits. See also panic disorder (PAND1; 167870), which is a subtype of anxiety disorder. [from GTR]

MedGen UID:
335849
Concept ID:
C1842981
Mental or Behavioral Dysfunction
6.

Depression

An emotional state characterized by feelings of sadness, emptiness, and/or tearfulness. [from NCI]

MedGen UID:
137999
Concept ID:
C0344315
Finding
7.

Sleep disturbance

An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness. [from HPO]

MedGen UID:
52372
Concept ID:
C0037317
Sign or Symptom
8.

Symptoms of depression

MedGen UID:
39170
Concept ID:
C0086132
Sign or Symptom
9.

Depression

A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure. [from HPO]

MedGen UID:
4229
Concept ID:
C0011581
Mental or Behavioral Dysfunction
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