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Items: 13

1.

saikosaponin A

MedGen UID:
91347
Concept ID:
C0377261
Organic Chemical; Pharmacologic Substance
2.

Dexamethasone

A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04) [from NCI]

MedGen UID:
8344
Concept ID:
C0011777
Organic Chemical; Pharmacologic Substance
3.

Caspase Inhibitor

Any substance that inhibits a caspase-family protease. Caspases play a key role in apoptosis as well as in inflammation and immune regulation. Caspase inhibition can be used to regulate these processes. [from NCI]

MedGen UID:
273884
Concept ID:
C1516312
Pharmacologic Substance
4.

DNA Fragmentation

A process that results in the breaking of macromolecular DNA into small pieces. [from NCI]

MedGen UID:
138244
Concept ID:
C0376669
Molecular Function
5.

Peptide hydrolase inhibitor

Any substance that inhibits a protease, an enzyme that breaks peptide bonds. Proteases are required for many cell processes and inhibition of proteases can inhibit viral replication, inflammatory responses, proliferation, and tumor growth. [from NCI]

MedGen UID:
18701
Concept ID:
C0033607
Pharmacologic Substance
6.

Enzyme inhibitor

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from MeSH]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance
7.

DNA damage

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis. [from NCI]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
8.

Amino Acid Chloromethyl Ketones

Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process. [from MeSH]

MedGen UID:
1865
Concept ID:
C0002512
Amino Acid, Peptide, or Protein; Pharmacologic Substance
9.

Inhibitors, Cysteine Proteinase

Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES. [from MeSH]

MedGen UID:
1203
Concept ID:
C0010658
Biologically Active Substance; Pharmacologic Substance
10.

Amino acid

Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
11.

FK 009

MedGen UID:
772387
Concept ID:
C3658188
Amino Acid, Peptide, or Protein; Pharmacologic Substance
12.

Ac-ZVAD-FMK

MedGen UID:
242131
Concept ID:
C0971245
Amino Acid, Peptide, or Protein; Pharmacologic Substance
13.

benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone

MedGen UID:
94041
Concept ID:
C0383779
Amino Acid, Peptide, or Protein; Pharmacologic Substance
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