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Items: 17

1.

Zinc

An element with atomic symbol Zn, atomic number 30, and atomic weight 65.39. [from NCI]

MedGen UID:
22752
Concept ID:
C0043481
Biologically Active Substance; Element, Ion, or Isotope; Pharmacologic Substance
2.

Inflammation

A localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. [from NCI]

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
3.

Cachexia

Severe weight loss, wasting of muscle, loss of appetite, and general debility related to a chronic disease. [from HPO]

MedGen UID:
2773
Concept ID:
C0006625
Sign or Symptom
4.

Paraneoplastic neurologic syndrome

MedGen UID:
797890
Concept ID:
C3267031
Pathologic Function
5.

Severe inflammation

MedGen UID:
637405
Concept ID:
C0522569
Finding
6.

Premature centromere division

MedGen UID:
349138
Concept ID:
C1859308
Disease or Syndrome
7.

Severe

Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
104640
Concept ID:
C0205082
Qualitative Concept
8.

Oncolysis

The destruction of tumor cells or a reduction in swelling. [from NCI]

MedGen UID:
90709
Concept ID:
C0333516
Neoplastic Process
9.

Primary ciliary dyskinesia

Primary ciliary dyskinesia (PCD) is associated with situs abnormalities, abnormal sperm motility, and abnormal ciliary structure and function that result in retention of mucus and bacteria in the respiratory tract leading to chronic otosinopulmonary disease. More than 75% of full-term neonates with PCD have ‘neonatal respiratory distress’ requiring supplemental oxygen for days to weeks. Chronic airway infection, apparent in early childhood, results in bronchiectasis that is almost uniformly present in adulthood. Nasal congestion and sinus infections, apparent in early childhood, persist through adulthood. Chronic/recurrent ear infection, apparent in most young children, can be associated with transient or later irreversible hearing loss. Situs inversus totalis (mirror-image reversal of all visceral organs with no apparent physiologic consequences) is present in 40%-50% of individuals with PCD; heterotaxy (discordance of right and left patterns of ordinarily asymmetric structures that can be associated with significant malformations) is present in approximately 12%. Virtually all males with PCD are infertile as a result of abnormal sperm motility. [from GeneReviews]

MedGen UID:
3467
Concept ID:
C0008780
Disease or Syndrome
10.

Weight loss

Decrease in existing BODY WEIGHT. [from MeSH]

MedGen UID:
853198
Concept ID:
C1262477
Finding; Finding
11.

Polysaccharide

linear or branched chain structure containing many sugar molecules linked by glycosidic bonds. [from CRISP]

MedGen UID:
46014
Concept ID:
C0032594
Organic Chemical; Pharmacologic Substance
12.

Endopeptidases

nonEC category which corresponds to EC 3.4.21, EC 3.4.22, EC 3.4.23, EC 3.4.24, and EC 3.4.99. [from CRISP]

MedGen UID:
45389
Concept ID:
C0030946
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
13.

Clinical finding

clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient. [from CRISP]

MedGen UID:
19974
Concept ID:
C0037088
Sign or Symptom
14.

Phosphorylation

A process in which a phosphate group is added to a molecule, such as a sugar or a protein. [from NCI_NCI-GLOSS]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
15.

Emaciated

Clinical manifestation of excessive LEANNESS usually caused by disease or a lack of nutrition (MALNUTRITION). [from MeSH]

MedGen UID:
8585
Concept ID:
C0013911
Sign or Symptom
16.

Weight change

A clinical manifestation consisting of alterations in an individual's weight from his or her norm. [from MeSH]

MedGen UID:
2305
Concept ID:
C0005911
Finding
17.

Finding of digit of hand

MedGen UID:
676660
Concept ID:
C0730480
Finding
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