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Items: 15

1.

Nocodazole

A synthetic tubulin-binding agent with antineoplastic activity. Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics. This prevents mitosis and induces apoptosis in tumor cells. Although nocodazole binding site overlaps with that of colchicine, the two agents are structurally quite different. [from NCI]

MedGen UID:
14391
Concept ID:
C0028247
Organic Chemical; Pharmacologic Substance
2.

Taxol

brand name of Paclitaxel an anti-cancer drug [from CHV]

MedGen UID:
151846
Concept ID:
C0678133
Organic Chemical; Pharmacologic Substance
3.

Colchicine

A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE). [from MeSH]

MedGen UID:
3148
Concept ID:
C0009262
Organic Chemical; Pharmacologic Substance
4.

Ability to balance

The maintenance of a stable, upright body position. [from NCI]

MedGen UID:
154340
Concept ID:
C0560184
Finding
5.

Metabolic Networks and Pathways

Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites. [from MeSH]

MedGen UID:
328456
Concept ID:
C1721099
Molecular Function
6.

R-17934

MedGen UID:
168042
Concept ID:
C0878453
Organic Chemical; Pharmacologic Substance
7.

NSC-238159

MedGen UID:
168041
Concept ID:
C0878452
Organic Chemical; Pharmacologic Substance
8.

MAP Kinase Signaling System

An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade. [from MeSH]

MedGen UID:
155748
Concept ID:
C0752321
Molecular Function
9.

Nitrile

An organic compound that contains a cyano moiety (-CN) as a functional group. [from NCI]

MedGen UID:
45099
Concept ID:
C0028131
Organic Chemical; Pharmacologic Substance
10.

Enzyme activation

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme. [from MeSH]

MedGen UID:
41819
Concept ID:
C0014429
Molecular Function
11.

Protein binding

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. [from MeSH]

MedGen UID:
18704
Concept ID:
C0033618
Molecular Function
12.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
13.

Bioflavonoid preparation

Naturally occurring flavone or coumarin derivatives having the activity of the so-called vitamin P, notably rutin and esculin. [from NCI]

MedGen UID:
2254
Concept ID:
C0005492
Organic Chemical; Pharmacologic Substance; Vitamin
14.

Balancing when reaching

MedGen UID:
646650
Concept ID:
C0562285
Finding
15.

Does not balance when reaching

MedGen UID:
646649
Concept ID:
C0562284
Finding
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