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Items: 20

1.

Epidermal growth factor

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form. [from MeSH]

MedGen UID:
66867
Concept ID:
C0242275
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
2.

Tyrosine

A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin. [from MeSH]

MedGen UID:
21746
Concept ID:
C0041485
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
3.

Phosphorylation

A process in which a phosphate group is added to a molecule, such as a sugar or a protein. [from NCI_NCI-GLOSS]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
4.

Tyrosine Phosphorylation

Tyrosine phosphorylation involves the introduction of a phosphoryl group into a compound through the formation of an ester bond between a tyrosine residue in the compound and a phosphorus moiety. [from NCI]

MedGen UID:
274331
Concept ID:
C1519726
Molecular Function
5.

Myristate

14 carbon straight chain saturated fatty acid common in membrane phospholipids and fatty acylated proteins. [from CRISP]

MedGen UID:
51290
Concept ID:
C0129533
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
6.

Insulin

Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism. [from NCI]

MedGen UID:
5827
Concept ID:
C0021641
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
7.

Mobility

Ability to move purposefully in own environment independently with or without assistive device [from NOC]

MedGen UID:
603859
Concept ID:
C0425245
Finding
8.

Acetate

salts or esters of acetic acid in which the terminal hydrogen atom is replaced by a metal, for instance copper acetate Cu(CH3COO)2, or where substitution is by a radical, for instance ethyl acetate CH3COOC2H5. [from CRISP]

MedGen UID:
452099
Concept ID:
C0000975
Organic Chemical; Pharmacologic Substance
9.

metaplastic cell transformation

The conversion of a cell from a normal phenotype, which undergoes a limited number of mitotic divisions, into an aberrant phenotype that is immortal and divides indefinitely. Transformed cells no longer retain cell-cycle checkpoints and may ultimately become malignant cancer cells via additional genetic mutations, or damaging environmental events. [from NCI]

MedGen UID:
266929
Concept ID:
C1510411
Pathologic Function
10.

Signal Transduction Pathways

An elaboration of the known or inferred interactions involved in a signal transduction pathway. [from NCI]

MedGen UID:
39530
Concept ID:
C0086982
Molecular Function
11.

Mitogens

A soluble substance, usually a protein, that induces mitosis in resting cells, thereby causing cell proliferation. [from NCI]

MedGen UID:
7665
Concept ID:
C0026249
Pharmacologic Substance
12.

Carcinogenesis

The process by which normal cells are transformed into cancer cells. [from NCI_NCI-GLOSS]

MedGen UID:
154544
Concept ID:
C0596263
Neoplastic Process
13.

Pyrazoles

Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions. [from MeSH]

MedGen UID:
48274
Concept ID:
C0034242
Organic Chemical; Pharmacologic Substance
14.

Neoplastic Processes

The pathological mechanisms and forms taken by tissue during degeneration into a neoplasm and its subsequent activity. [from MeSH]

MedGen UID:
14325
Concept ID:
C0027671
Neoplastic Process
15.

Hormones, Hormone Substitutes, and Hormone Antagonists

A collective grouping for both naturally occurring and synthetic hormones, substitutes, and antagonists. [from MeSH]

MedGen UID:
6887
Concept ID:
C0019934
Pharmacologic Substance
16.

Tumorigenesis

A pathologic process that involves the transformation of normal cells to a neoplastic state and resulting in polyclonal or monoclonal neoplastic cell proliferation. [from NCI]

MedGen UID:
3302
Concept ID:
C0007621
Neoplastic Process
17.

Bioflavonoids

Naturally occurring flavone or coumarin derivatives having the activity of the so-called vitamin P, notably rutin and esculin. [from NCI]

MedGen UID:
2254
Concept ID:
C0005492
Organic Chemical; Pharmacologic Substance; Vitamin
18.

Amino acid

Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
19.

CP118,556

MedGen UID:
156716
Concept ID:
C0754645
Organic Chemical; Pharmacologic Substance
20.

PP1 Src tyrosine kinase inhibitor

MedGen UID:
156193
Concept ID:
C0754646
Organic Chemical; Pharmacologic Substance
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