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Items: 1 to 20 of 30

1.

Thrombophilia

Prothrombin-related thrombophilia is characterized by venous thromboembolism (VTE) manifest most commonly in adults as deep-vein thrombosis (DVT) in the legs or pulmonary embolism. The clinical expression of prothrombin-related thrombophilia is variable; many individuals heterozygous or homozygous for the 20210G>A (G20210A or c.*97G>A) allele inF2never develop thrombosis, and while most heterozygotes who develop thrombotic complications remain asymptomatic until adulthood, some have recurrent thromboembolism before age 30 years. The relative risk for DVT in adults heterozygous for the 20210G>A allele is two- to fivefold increased; in children, the relative risk for thrombosis is three- to fourfold increased. 20210G>A heterozygosity has at most a modest effect on recurrence risk after a first episode. Although prothrombin-related thrombophilia may increase the risk for pregnancy loss, its association with preeclampsia and other complications of pregnancy such as intrauterine growth restriction and placental abruption remains controversial. Factors that predispose to thrombosis in prothrombin-related thrombophilia include: the number of 20210G>A alleles; presence of coexisting genetic abnormalities including factor V Leiden; and acquired thrombophilic disorders (e.g., antiphospholipid antibodies). Circumstantial risk factors for thrombosis include pregnancy and oral contraceptive use. Some evidence suggests that the risk for VTE in 20210G>A heterozygotes increases after travel. [from GeneReviews]

MedGen UID:
98306
Concept ID:
C0398623
Disease or Syndrome
2.

Deep venous thrombosis

MedGen UID:
57448
Concept ID:
C0149871
Disease or Syndrome
3.

Thrombosis

MedGen UID:
21160
Concept ID:
C0040053
Pathologic Function
4.

Error occurred: cannot get document summary

ID:
1462451

5.

Hypercoagulability

MedGen UID:
463623
Concept ID:
C3160733
Finding
6.

Folate

A cofactor for 1-carbon transfer involved with DNA synthesis. [from NCI]

MedGen UID:
59819
Concept ID:
C0178638
Organic Chemical; Pharmacologic Substance; Vitamin
7.

Folitixorin

A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity. [from NCI]

MedGen UID:
59057
Concept ID:
C0048858
Organic Chemical; Pharmacologic Substance; Vitamin
8.

Venous thrombosis

MedGen UID:
22631
Concept ID:
C0042487
Pathologic Function
9.

Plasminogen

Plasminogen (810 aa, ~91 kDa) is encoded by the human PLG gene. This protein is involved in fibrinolysis, platelet activation and tissue remodeling. [from NCI]

MedGen UID:
10793
Concept ID:
C0032140
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
10.

Lupus anticoagulant

MedGen UID:
1370558
Concept ID:
C4321325
Finding
11.

Not significant

MedGen UID:
697304
Concept ID:
C1273937
Finding
12.

Risk factor

An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, on the basis of epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. [from MeSH]

MedGen UID:
48477
Concept ID:
C0035648
Finding
13.

Vitamin preparation

A group of organic food substances found in animals and plants in small quantities. They must be supplied in diet or dietary supplement and are essential for normal metabolism. [from NCI]

MedGen UID:
12117
Concept ID:
C0042890
Organic Chemical; Pharmacologic Substance; Vitamin
14.

Anticoagulant

Agents that prevent BLOOD CLOTTING. [from MeSH]

MedGen UID:
1970
Concept ID:
C0003280
Pharmacologic Substance
15.

Genetic predisposition

MedGen UID:
137259
Concept ID:
C0314657
Organism Attribute
16.

Thrombus

MedGen UID:
43439
Concept ID:
C0087086
Pathologic Function
17.

Embolism and Thrombosis

A collective term for pathological conditions which are caused by the formation of a blood clot (THROMBUS) in a blood vessel, or by blocking of a blood vessel with an EMBOLUS, undissolved materials in the blood stream. [from MeSH]

MedGen UID:
43147
Concept ID:
C0085307
Disease or Syndrome
18.

Peripheral Vascular Diseases

MedGen UID:
38790
Concept ID:
C0085096
Disease or Syndrome
19.

Vascular disorder

MedGen UID:
22621
Concept ID:
C0042373
Disease or Syndrome
20.

Phlebitis

Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS). [from MeSH]

MedGen UID:
18425
Concept ID:
C0031542
Pathologic Function
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