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Tuberculosis

MedGen UID:
22513
Concept ID:
C0041296
Disease or Syndrome
Synonyms: Disease, Koch's; Disease, Kochs; Koch Disease; Koch's Disease; Kochs Disease; Tuberculoses
Modes of inheritance:
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
not inherited (Orphanet)
SNOMED CT: Tuberculous (371569005); Infection due to Mycobacterium tuberculosis (373576009); Infection caused by Mycobacterium tuberculosis (373576009); TB - Tuberculosis (56717001); Tuberculosis (56717001)
 
Orphanet: ORPHA3389

Definition

Tuberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but they can also damage other parts of the body. . TB spreads through the air when a person with TB of the lungs or throat coughs, sneezes, or talks. If you have been exposed, you should go to your doctor for tests. You are more likely to get TB if you have a weak immune system. Symptoms of TB in the lungs may include. - A bad cough that lasts 3 weeks or longer. - Weight loss. - Loss of appetite. - Coughing up blood or mucus. - Weakness or fatigue . - Fever. - Night sweats. Skin tests, blood tests, x-rays, and other tests can tell if you have TB. If not treated properly, TB can be deadly. You can usually cure active TB by taking several medicines for a long period of time. NIH: National Institute of Allergy and Infectious Diseases.  [from MedlinePlus]

Recent clinical studies

Etiology

Matteelli A, Sulis G, Capone S, D'Ambrosio L, Migliori GB, Getahun H
Presse Med 2017 Mar;46(2 Pt 2):e13-e21. Epub 2017 Mar 6 doi: 10.1016/j.lpm.2017.01.015. PMID: 28279508
Santin M, Morandeira-Rego F, Alcaide F, Rabuñal R, Anibarro L, Agüero-Balbín R, Casas-Garcia X, Pérez-Escolano E, Navarro MD, Sánchez F, Coira-Nieto A, Trigo-Daporta M, Martinez-Meñaca A, Gonzalez-Cuevas A, López-Prieto MD, Domínguez-Castellano A, Jové N; IL-2 Study Team.
Clin Microbiol Infect 2016 Dec;22(12):1007.e1-1007.e5. Epub 2016 Sep 16 doi: 10.1016/j.cmi.2016.09.004. PMID: 27647563
Igumnova V, Capligina V, Krams A, Cirule A, Elferts D, Pole I, Jansone I, Bandere D, Ranka R
J Infect Chemother 2016 Jul;22(7):472-7. Epub 2016 May 25 doi: 10.1016/j.jiac.2016.04.003. PMID: 27236516
Probandari A, Widjanarko B, Mahendradhata Y, Sanjoto H, Cerisha A, Nungky S, Riono P, Simon S, Farid MN, Giriputra S, Putra AE, Burhan E, Wahyuni CU, Mustikawati D, Widianingrum C, Tiemersma EW, Alisjahbana B; Tuberculosis Operational Research Group (TORG).
Glob Health Action 2016;9:29866. Epub 2016 Feb 25 PMID: 26928217Free PMC Article
Wang X, Liu H, Wei J, Wu X, Yu Q, Zhao X, Lyu J, Lou Y, Wan K
Tuberculosis (Edinb) 2015 Dec;95(6):695-700. Epub 2015 Oct 19 doi: 10.1016/j.tube.2015.08.006. PMID: 26542224

Diagnosis

Santin M, Morandeira-Rego F, Alcaide F, Rabuñal R, Anibarro L, Agüero-Balbín R, Casas-Garcia X, Pérez-Escolano E, Navarro MD, Sánchez F, Coira-Nieto A, Trigo-Daporta M, Martinez-Meñaca A, Gonzalez-Cuevas A, López-Prieto MD, Domínguez-Castellano A, Jové N; IL-2 Study Team.
Clin Microbiol Infect 2016 Dec;22(12):1007.e1-1007.e5. Epub 2016 Sep 16 doi: 10.1016/j.cmi.2016.09.004. PMID: 27647563
Pathakumari B, Prabhavathi M, Anbarasu D, Paramanandhan P, Raja A
Clin Chim Acta 2016 Oct 1;461:25-33. Epub 2016 Jun 28 doi: 10.1016/j.cca.2016.06.033. PMID: 27370403
Chen T, Li Z, Yu L, Li H, Lin J, Guo H, Wang W, Chen L, Zhang X, Wang Y, Chen Y, Liao Q, Tan Y, Shu Y, Huang W, Cai C, Zhou Z, Yu M, Li G, Zhou L, Zhong Q, Bi L, Zhao M, Guo L, Zhou J
Tuberculosis (Edinb) 2016 Mar;97:108-17. Epub 2016 Jan 14 doi: 10.1016/j.tube.2015.12.007. PMID: 26980502
Wang X, Liu H, Wei J, Wu X, Yu Q, Zhao X, Lyu J, Lou Y, Wan K
Tuberculosis (Edinb) 2015 Dec;95(6):695-700. Epub 2015 Oct 19 doi: 10.1016/j.tube.2015.08.006. PMID: 26542224
Song KS, Nimse SB, Cho NH, Sung N, Kim HJ, Yang J, Kim T
Tuberculosis (Edinb) 2015 Dec;95(6):780-5. Epub 2015 Sep 5 doi: 10.1016/j.tube.2015.08.008. PMID: 26381057

Therapy

Matteelli A, Sulis G, Capone S, D'Ambrosio L, Migliori GB, Getahun H
Presse Med 2017 Mar;46(2 Pt 2):e13-e21. Epub 2017 Mar 6 doi: 10.1016/j.lpm.2017.01.015. PMID: 28279508
Choi R, Jeong BH, Koh WJ, Lee SY
Ann Lab Med 2017 Mar;37(2):97-107. doi: 10.3343/alm.2017.37.2.97. PMID: 28028995Free PMC Article
Parumasivam T, Chan JG, Pang A, Quan DH, Triccas JA, Britton WJ, Chan HK
Eur J Pharm Biopharm 2016 Oct;107:205-14. Epub 2016 Jul 12 doi: 10.1016/j.ejpb.2016.07.014. PMID: 27422209
Chen T, Li Z, Yu L, Li H, Lin J, Guo H, Wang W, Chen L, Zhang X, Wang Y, Chen Y, Liao Q, Tan Y, Shu Y, Huang W, Cai C, Zhou Z, Yu M, Li G, Zhou L, Zhong Q, Bi L, Zhao M, Guo L, Zhou J
Tuberculosis (Edinb) 2016 Mar;97:108-17. Epub 2016 Jan 14 doi: 10.1016/j.tube.2015.12.007. PMID: 26980502
Song KS, Nimse SB, Cho NH, Sung N, Kim HJ, Yang J, Kim T
Tuberculosis (Edinb) 2015 Dec;95(6):780-5. Epub 2015 Sep 5 doi: 10.1016/j.tube.2015.08.008. PMID: 26381057

Prognosis

Matteelli A, Sulis G, Capone S, D'Ambrosio L, Migliori GB, Getahun H
Presse Med 2017 Mar;46(2 Pt 2):e13-e21. Epub 2017 Mar 6 doi: 10.1016/j.lpm.2017.01.015. PMID: 28279508
Papaventsis D, Casali N, Kontsevaya I, Drobniewski F, Cirillo DM, Nikolayevskyy V
Clin Microbiol Infect 2017 Feb;23(2):61-68. Epub 2016 Sep 22 doi: 10.1016/j.cmi.2016.09.008. PMID: 27665704
Srivastava S, Pasipanodya JG, Ramachandran G, Deshpande D, Shuford S, Crosswell HE, Cirrincione KN, Sherman CM, Swaminathan S, Gumbo T
EBioMedicine 2016 Apr;6:126-38. Epub 2016 Feb 27 doi: 10.1016/j.ebiom.2016.02.040. PMID: 27211555Free PMC Article
Chen T, Li Z, Yu L, Li H, Lin J, Guo H, Wang W, Chen L, Zhang X, Wang Y, Chen Y, Liao Q, Tan Y, Shu Y, Huang W, Cai C, Zhou Z, Yu M, Li G, Zhou L, Zhong Q, Bi L, Zhao M, Guo L, Zhou J
Tuberculosis (Edinb) 2016 Mar;97:108-17. Epub 2016 Jan 14 doi: 10.1016/j.tube.2015.12.007. PMID: 26980502
Song KS, Nimse SB, Cho NH, Sung N, Kim HJ, Yang J, Kim T
Tuberculosis (Edinb) 2015 Dec;95(6):780-5. Epub 2015 Sep 5 doi: 10.1016/j.tube.2015.08.008. PMID: 26381057

Clinical prediction guides

Matteelli A, Sulis G, Capone S, D'Ambrosio L, Migliori GB, Getahun H
Presse Med 2017 Mar;46(2 Pt 2):e13-e21. Epub 2017 Mar 6 doi: 10.1016/j.lpm.2017.01.015. PMID: 28279508
Papaventsis D, Casali N, Kontsevaya I, Drobniewski F, Cirillo DM, Nikolayevskyy V
Clin Microbiol Infect 2017 Feb;23(2):61-68. Epub 2016 Sep 22 doi: 10.1016/j.cmi.2016.09.008. PMID: 27665704
Igumnova V, Capligina V, Krams A, Cirule A, Elferts D, Pole I, Jansone I, Bandere D, Ranka R
J Infect Chemother 2016 Jul;22(7):472-7. Epub 2016 May 25 doi: 10.1016/j.jiac.2016.04.003. PMID: 27236516
Chen T, Li Z, Yu L, Li H, Lin J, Guo H, Wang W, Chen L, Zhang X, Wang Y, Chen Y, Liao Q, Tan Y, Shu Y, Huang W, Cai C, Zhou Z, Yu M, Li G, Zhou L, Zhong Q, Bi L, Zhao M, Guo L, Zhou J
Tuberculosis (Edinb) 2016 Mar;97:108-17. Epub 2016 Jan 14 doi: 10.1016/j.tube.2015.12.007. PMID: 26980502
Song KS, Nimse SB, Cho NH, Sung N, Kim HJ, Yang J, Kim T
Tuberculosis (Edinb) 2015 Dec;95(6):780-5. Epub 2015 Sep 5 doi: 10.1016/j.tube.2015.08.008. PMID: 26381057

Recent systematic reviews

Papaventsis D, Casali N, Kontsevaya I, Drobniewski F, Cirillo DM, Nikolayevskyy V
Clin Microbiol Infect 2017 Feb;23(2):61-68. Epub 2016 Sep 22 doi: 10.1016/j.cmi.2016.09.008. PMID: 27665704
Khan MS, Khine TM, Hutchison C, Coker RJ, Hane KM, Innes AL, Aung S
BMC Infect Dis 2016 Mar 3;16:110. doi: 10.1186/s12879-016-1429-y. PMID: 26940910Free PMC Article
Probandari A, Widjanarko B, Mahendradhata Y, Sanjoto H, Cerisha A, Nungky S, Riono P, Simon S, Farid MN, Giriputra S, Putra AE, Burhan E, Wahyuni CU, Mustikawati D, Widianingrum C, Tiemersma EW, Alisjahbana B; Tuberculosis Operational Research Group (TORG).
Glob Health Action 2016;9:29866. Epub 2016 Feb 25 PMID: 26928217Free PMC Article
Gupta A, Mathad JS, Abdel-Rahman SM, Albano JD, Botgros R, Brown V, Browning RS, Dawson L, Dooley KE, Gnanashanmugam D, Grinsztejn B, Hernandez-Diaz S, Jean-Philippe P, Kim P, Lyerly AD, Mirochnick M, Mofenson LM, Montepiedra G, Piper J, Sahin L, Savic R, Smith B, Spiegel H, Swaminathan S, Watts DH, White A
Clin Infect Dis 2016 Mar 15;62(6):761-9. Epub 2015 Dec 9 doi: 10.1093/cid/civ991. PMID: 26658057Free PMC Article
Graham SM, Cuevas LE, Jean-Philippe P, Browning R, Casenghi M, Detjen AK, Gnanashanmugam D, Hesseling AC, Kampmann B, Mandalakas A, Marais BJ, Schito M, Spiegel HM, Starke JR, Worrell C, Zar HJ
Clin Infect Dis 2015 Oct 15;61Suppl 3:S179-87. doi: 10.1093/cid/civ581. PMID: 26409281Free PMC Article

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