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Acetylcholine

MedGen UID:
7841
Concept ID:
C0001041
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
Synonyms: 2-(Acetyloxy)-N,N,N-trimethylethanaminium; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-
SNOMED CT: Acetylcholine preparation (13525006); Acetylcholine (13525006); Acetylcholine (57308006)
 

Definition

A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcetylcholine

Recent clinical studies

Etiology

Damm MMB, Jensen TSR, Mahmood B, Lundh M, Poulsen SS, Bindslev N, Hansen MB
Mol Carcinog 2017 Oct;56(10):2223-2233. Epub 2017 Jun 15 doi: 10.1002/mc.22675. PMID: 28544328
Maley MJ, House JR, Tipton MJ, Eglin CM
Microvasc Res 2017 May;111:80-87. Epub 2017 Jan 17 doi: 10.1016/j.mvr.2017.01.005. PMID: 28108308
Marshall-Gradisnik S, Johnston S, Chacko A, Nguyen T, Smith P, Staines D
J Int Med Res 2016 Dec;44(6):1381-1394. Epub 2016 Nov 11 doi: 10.1177/0300060516671622. PMID: 27834303Free PMC Article
Silva I, Ferreirinha F, Magalhães-Cardoso MT, Silva-Ramos M, Correia-de-Sá P
J Urol 2015 Oct;194(4):1146-54. Epub 2015 May 21 doi: 10.1016/j.juro.2015.05.080. PMID: 26004864
Bäckström G, Lundberg B, Behndig A
Acta Ophthalmol 2013 Mar;91(2):123-6. Epub 2012 Mar 16 doi: 10.1111/j.1755-3768.2011.02376.x. PMID: 22429618

Diagnosis

Post-Munson DJ, Pieschl RL, Molski TF, Graef JD, Hendricson AW, Knox RJ, McDonald IM, Olson RE, Macor JE, Weed MR, Bristow LJ, Kiss L, Ahlijanian MK, Herrington J
Eur J Pharmacol 2017 Mar 15;799:16-25. Epub 2017 Jan 26 doi: 10.1016/j.ejphar.2017.01.037. PMID: 28132910
Moreira FTC, Sale MGF, Di Lorenzo M
Biosens Bioelectron 2017 Jan 15;87:607-614. Epub 2016 Aug 30 doi: 10.1016/j.bios.2016.08.104. PMID: 27616286
Ong P, Athanasiadis A, Sechtem U
J Vis Exp 2016 Aug 18;(114) doi: 10.3791/54295. PMID: 27583694
Silva I, Ferreirinha F, Magalhães-Cardoso MT, Silva-Ramos M, Correia-de-Sá P
J Urol 2015 Oct;194(4):1146-54. Epub 2015 May 21 doi: 10.1016/j.juro.2015.05.080. PMID: 26004864
Ong P, Athanasiadis A, Borgulya G, Vokshi I, Bastiaenen R, Kubik S, Hill S, Schäufele T, Mahrholdt H, Kaski JC, Sechtem U
Circulation 2014 Apr 29;129(17):1723-30. Epub 2014 Feb 26 doi: 10.1161/CIRCULATIONAHA.113.004096. PMID: 24573349

Therapy

Falkenburger B
J Neurochem 2017 Mar;140(5):688-691. Epub 2017 Jan 6 doi: 10.1111/jnc.13899. PMID: 28058727
Grimaldi M, Marino SD, Florenzano F, Ciotta MT, Nori SL, Rodriquez M, Sorrentino G, D'Ursi AM, Scrima M
Future Med Chem 2016 Jul;8(11):1179-89. Epub 2016 Jul 12 doi: 10.4155/fmc-2016-0006. PMID: 27402297
Morgan ML, Sigala B, Soeda J, Cordero P, Nguyen V, McKee C, Mouraliderane A, Vinciguerra M, Oben JA
J Gastroenterol Hepatol 2016 Feb;31(2):475-83. doi: 10.1111/jgh.13085. PMID: 26270240
Kistemaker LE, Gosens R
Trends Pharmacol Sci 2015 Mar;36(3):164-71. Epub 2014 Dec 13 doi: 10.1016/j.tips.2014.11.005. PMID: 25511176
Ong P, Athanasiadis A, Borgulya G, Vokshi I, Bastiaenen R, Kubik S, Hill S, Schäufele T, Mahrholdt H, Kaski JC, Sechtem U
Circulation 2014 Apr 29;129(17):1723-30. Epub 2014 Feb 26 doi: 10.1161/CIRCULATIONAHA.113.004096. PMID: 24573349

Prognosis

Shen XM, Brengman J, Neubauer D, Sine SM, Engel AG
J Biol Chem 2016 Feb 12;291(7):3291-301. Epub 2015 Dec 23 doi: 10.1074/jbc.M115.683995. PMID: 26698174Free PMC Article
Sueda S, Miyoshi T, Sasaki Y, Sakaue T, Habara H, Kohno H
Heart Vessels 2016 Mar;31(3):322-9. Epub 2014 Dec 25 doi: 10.1007/s00380-014-0614-4. PMID: 25539623
Sueda S, Miyoshi T, Sasaki Y, Ohshima K, Sakaue T, Habara H, Kohno H
Heart Vessels 2016 Feb;31(2):143-51. Epub 2014 Nov 4 doi: 10.1007/s00380-014-0595-3. PMID: 25366988
Danielmeier C, Allen EA, Jocham G, Onur OA, Eichele T, Ullsperger M
Curr Biol 2015 Jun 1;25(11):1461-8. Epub 2015 May 7 doi: 10.1016/j.cub.2015.04.022. PMID: 25959965
Pochini L, Scalise M, Galluccio M, Pani G, Siminovitch KA, Indiveri C
Biochim Biophys Acta 2012 Mar;1818(3):559-65. Epub 2011 Dec 21 doi: 10.1016/j.bbamem.2011.12.014. PMID: 22206629

Clinical prediction guides

Pochini L, Scalise M, Di Silvestre S, Belviso S, Pandolfi A, Arduini A, Bonomini M, Indiveri C
Biochim Biophys Acta 2016 Apr;1858(4):653-60. Epub 2015 Dec 23 doi: 10.1016/j.bbamem.2015.12.026. PMID: 26724204
Shen XM, Brengman J, Neubauer D, Sine SM, Engel AG
J Biol Chem 2016 Feb 12;291(7):3291-301. Epub 2015 Dec 23 doi: 10.1074/jbc.M115.683995. PMID: 26698174Free PMC Article
Roy A, Dakroub M, Tezini GC, Liu Y, Guatimosim S, Feng Q, Salgado HC, Prado VF, Prado MA, Gros R
FASEB J 2016 Feb;30(2):688-701. Epub 2015 Oct 19 doi: 10.1096/fj.15-277046. PMID: 26481308
Jiang L, Kosenko A, Yu C, Huang L, Li X, Hoshi N
J Cell Sci 2015 Nov 15;128(22):4235-45. Epub 2015 Oct 7 doi: 10.1242/jcs.175547. PMID: 26446259Free PMC Article
Paparini D, Gori S, Grasso E, Scordo W, Calo G, Pérez Leirós C, Ramhorst R, Salamone G
Acta Physiol (Oxf) 2015 Jun;214(2):237-47. Epub 2015 Apr 6 doi: 10.1111/apha.12494. PMID: 25819434

Recent systematic reviews

Sutherland MT, Ray KL, Riedel MC, Yanes JA, Stein EA, Laird AR
Biol Psychiatry 2015 Nov 15;78(10):711-20. Epub 2015 Jan 7 doi: 10.1016/j.biopsych.2014.12.021. PMID: 25662104Free PMC Article
Picciotto MR, Lewis AS, van Schalkwyk GI, Mineur YS
Neuropharmacology 2015 Sep;96(Pt B):235-43. Epub 2015 Jan 9 doi: 10.1016/j.neuropharm.2014.12.028. PMID: 25582289Free PMC Article
Riese H, Muñoz LM, Hartman CA, Ding X, Su S, Oldehinkel AJ, van Roon AM, van der Most PJ, Lefrandt J, Gansevoort RT, van der Harst P, Verweij N, Licht CM, Boomsma DI, Hottenga JJ, Willemsen G, Penninx BW, Nolte IM, de Geus EJ, Wang X, Snieder H
PLoS One 2014;9(11):e112476. Epub 2014 Nov 10 doi: 10.1371/journal.pone.0112476. PMID: 25384021Free PMC Article
Brunzell DH
Nicotine Tob Res 2012 Nov;14(11):1258-69. Epub 2012 Apr 6 doi: 10.1093/ntr/nts089. PMID: 22492084Free PMC Article
Williams MJ, Adinoff B
Neuropsychopharmacology 2008 Jul;33(8):1779-97. Epub 2007 Oct 10 doi: 10.1038/sj.npp.1301585. PMID: 17928814Free PMC Article

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