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Items: 1 to 20 of 86

1.

Acute myeloid leukemia

CEBPA-associated familial acute myeloid leukemia (AML) is defined as AML in which a heterozygous germline CEBPA pathogenic variant is present in a family in which multiple individuals have AML. In contrast, sporadic CEBPA-associated AML is defined as AML in which a CEBPA pathogenic variant(s) is identified in leukemic cells but not in the non-leukemic cells. Too few individuals with CEBPA-associated familial AML have been reported to be certain about the natural history of the disease. In the majority of individuals, the age of onset of familial AML appears to be earlier than sporadic AML; disease onset has been reported in persons as young as age 1.8 years and older than age 45 years. The prognosis of CEBPA-associated familial AML appears to be favorable compared with sporadic CEBPA-associated AML. Individuals with CEBPA-associated familial AML who have been cured of their initial disease may be at greater risk of developing additional independent leukemic episodes in addition to the risk of relapse due to preexisting clones. [from GTR]

MedGen UID:
9730
Concept ID:
C0023467
Neoplastic Process
2.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [from HPO]

MedGen UID:
9725
Concept ID:
C0023418
Neoplastic Process
3.

Acute myeloid leukemia

A form of leukemia characterized by overproduction of an early myeloid cell. [from HPO]

MedGen UID:
505691
Concept ID:
CN004254
Finding
4.

Mitochondrial import-stimulating factor

MedGen UID:
331468
Concept ID:
C1833246
Molecular Function
5.

Therapy-Related Acute Myeloid Leukemia

An acute myeloid leukemia arising as a result of the mutagenic effect of chemotherapy agents and/or ionizing radiation. (WHO, 2001) [from NCI]

MedGen UID:
237008
Concept ID:
C1336735
Neoplastic Process
6.

Myeloid leukemia

A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia. [from NCI]

MedGen UID:
7320
Concept ID:
C0023470
Neoplastic Process
7.

Topoisomerase-II Inhibitor

Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA double helix. A topoisomerase II inhibitor can either stabilize the DNA-protein complex or inhibit the catalytic activity of the enzyme. Inhibition of topoisomerase-II causes DNA damage, inhibition of DNA replication, and apoptosis. [from NCI]

MedGen UID:
275487
Concept ID:
C1519554
Pharmacologic Substance
8.

Hodgkin lymphoma

Hodgkin lymphoma (HL) is a heterogeneous group of malignant lymphoid neoplasms of B-cell origin characterized histologically by the presence of Hodgkin and Reed-Sternberg (HRS) cells in the vast majority of cases. [from ORDO]

MedGen UID:
799611
Concept ID:
CN206988
Disease or Syndrome
9.

Therapy-Related Leukemia

A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor or exposure to ionizing radiation. [from NCI]

MedGen UID:
414619
Concept ID:
C2825306
Neoplastic Process
10.

GTP Binding

GTP Binding is a molecular interaction between specific proteins (containing a GTP binding site) and guanosine 5-prime triphosphate during diverse cellular processes, such as RNA synthesis, translation, signal transduction, and cytoskeletal assembly. [from NCI]

MedGen UID:
216943
Concept ID:
C1149035
Molecular Function
11.

Frequent

Coming at short intervals or in great quantities. [from NCI]

MedGen UID:
87144
Concept ID:
C0332183
Temporal Concept
12.

Acute

Sudden appearance of disease manifestations over a short period of time. [from HPO]

MedGen UID:
61381
Concept ID:
C0205178
Temporal Concept
13.

Hyperreflexia

Autonomic nervous system overreaction to stimuli, most commonly after spinal cord injury at a T-5 level and above. [from NCI]

MedGen UID:
57738
Concept ID:
C0151889
Finding
14.

Cytophosphan

MedGen UID:
501178
Concept ID:
C3495431
Organic Chemical; Pharmacologic Substance
15.

Winpred

MedGen UID:
327709
Concept ID:
C1564200
Organic Chemical; Pharmacologic Substance
16.

Fawns & McAllan Brand of Prednisone

MedGen UID:
327708
Concept ID:
C1564199
Organic Chemical; Pharmacologic Substance
17.

Cutason

MedGen UID:
327705
Concept ID:
C1564190
Organic Chemical; Pharmacologic Substance
18.

Apo-Prednisone

MedGen UID:
327704
Concept ID:
C1564188
Organic Chemical; Pharmacologic Substance
19.

Predniment

MedGen UID:
308032
Concept ID:
C1514382
Organic Chemical; Pharmacologic Substance
20.

DeCortin

MedGen UID:
308027
Concept ID:
C1514369
Hormone; Organic Chemical; Pharmacologic Substance
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