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Items: 1 to 20 of 21

1.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
2.

DNA damage

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis. [from NCI]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
3.

Maternal

A designation that has some relationship to motherhood. [from NCI]

MedGen UID:
348949
Concept ID:
C1858460
Finding
4.

DNA Replication Damage

DNA sequence errors introduced via DNA replication. [from NCI]

MedGen UID:
267857
Concept ID:
C1511690
Cell or Molecular Dysfunction
5.

Reproductive Sterility

Complete inability to conceive or induce conception. [from MeSH]

MedGen UID:
882191
Concept ID:
C4074771
Pathologic Function
6.

Subfertility

MedGen UID:
452706
Concept ID:
C0729353
Disease or Syndrome
7.

Subfertility, Female

MedGen UID:
452445
Concept ID:
C0341869
Disease or Syndrome
8.

Female Urogenital Diseases

Pathological processes of the female URINARY TRACT and the reproductive system (GENITALIA, FEMALE). [from MeSH]

MedGen UID:
318599
Concept ID:
C1720887
Disease or Syndrome
9.

Female Urogenital Diseases and Pregnancy Complications

Pathological processes of the female URINARY TRACT, the reproductive system (GENITALIA, FEMALE), and disorders related to PREGNANCY. [from MeSH]

MedGen UID:
318565
Concept ID:
C1720765
Disease or Syndrome
10.

Biosynthesis, Peptide

The production of PEPTIDES or PROTEINS by the constituents of a living organism. The biosynthesis of proteins on RIBOSOMES following an RNA template is termed translation (TRANSLATION, GENETIC). There are other, non-ribosomal peptide biosynthesis (PEPTIDE BIOSYNTHESIS, NUCLEIC ACID-INDEPENDENT) mechanisms carried out by PEPTIDE SYNTHASES and PEPTIDYLTRANSFERASES. Further modifications of peptide chains yield functional peptide and protein molecules. [from MeSH]

MedGen UID:
272130
Concept ID:
C1327133
Molecular Function
11.

Protein Modification, Translational

Any of the enzymatically catalyzed modifications of the individual AMINO ACIDS of PROTEINS, and enzymatic cleavage or crosslinking of peptide chains that occur pre-translationally (on the amino acid component of AMINO ACYL TRNA), co-translationally (during the process of GENETIC TRANSLATION), or after translation is completed (POST-TRANSLATIONAL PROTEIN PROCESSING). [from MeSH]

MedGen UID:
260537
Concept ID:
C1449566
Molecular Function
12.

Female sterility

MedGen UID:
181472
Concept ID:
C0917730
Finding
13.

ICI-69653

MedGen UID:
164157
Concept ID:
C0878250
Organic Chemical; Pharmacologic Substance
14.

NSC-351140

MedGen UID:
163837
Concept ID:
C0878248
Organic Chemical; Pharmacologic Substance
15.

Genetic translation

Protein synthesis is the group of processes that are involved in generation of mature protein molecules. Although protein synthesis may involve translation alone in many cases, in others, it involves also protein folding, integration of prosthetic groups, glycosylation, methylation, phosphorylation, lipidation and any other process that may be involved in maturation of the polypeptide to the biologically active form. [from NCI]

MedGen UID:
108933
Concept ID:
C0597295
Molecular Function
16.

Aphidicolin

An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells. [from MeSH]

MedGen UID:
88346
Concept ID:
C0085171
Organic Chemical; Pharmacologic Substance
17.

Post-Translational Modification

The enzymatic processing of a polypeptide chain after translation from messenger RNA and after peptide bond formation has occurred. Examples include glycosylation, acylation, limited proteolysis, phosphorylation, isoprenylation.(On-line Medical Dictionary) [from NCI]

MedGen UID:
46159
Concept ID:
C0033666
Molecular Function
18.

Infertility

A reduced or absent capacity to reproduce. [from MeSH]

MedGen UID:
43876
Concept ID:
C0021359
Finding; Pathologic Function
19.

Sterility, Postpartum

MedGen UID:
11592
Concept ID:
C0038279
Pathologic Function
20.

Disorder of female genital system

Pathological processes involving the female reproductive tract (GENITALIA, FEMALE). [from MeSH]

MedGen UID:
9003
Concept ID:
C0017411
Disease or Syndrome
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