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Hemicholinium 3

MedGen UID:
6781
Concept ID:
C0018983
Organic Chemical; Pharmacologic Substance
Synonyms: Hemicholinium; Morpholinium, 2,2'-(1,1'-biphenyl)-4,4'-diylbis(2-hydroxy-4,4-dimethyl)-, dibromide
 

Definition

A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments. [from MeSH]

Recent clinical studies

Etiology

Profita M, Albano GD, Riccobono L, Di Sano C, Montalbano AM, Gagliardo R, Anzalone G, Bonanno A, Pieper MP, Gjomarkaj M
Immunobiology 2014 May;219(5):392-401. Epub 2014 Jan 25 doi: 10.1016/j.imbio.2014.01.004. PMID: 24529390
Zurkovsky L, Bychkov E, Tsakem EL, Siedlecki C, Blakely RD, Gurevich EV
Dis Model Mech 2013 Jan;6(1):171-83. Epub 2012 Aug 3 doi: 10.1242/dmm.010363. PMID: 22864020Free PMC Article
Barwick KE, Wright J, Al-Turki S, McEntagart MM, Nair A, Chioza B, Al-Memar A, Modarres H, Reilly MM, Dick KJ, Ruggiero AM, Blakely RD, Hurles ME, Crosby AH
Am J Hum Genet 2012 Dec 7;91(6):1103-7. Epub 2012 Nov 8 doi: 10.1016/j.ajhg.2012.09.019. PMID: 23141292Free PMC Article
Michel V, Yuan Z, Ramsubir S, Bakovic M
Exp Biol Med (Maywood) 2006 May;231(5):490-504. PMID: 16636297
Pascual J, Fontán A, Zarranz JJ, Berciano J, Flórez J, Pazos A
Brain Res 1991 Jun 21;552(1):170-4. PMID: 1913175

Diagnosis

Cuddy LK, Winick-Ng W, Rylett RJ
J Neurochem 2014 Mar;128(5):725-40. Epub 2013 Nov 4 doi: 10.1111/jnc.12490. PMID: 24127780
Hong BS, Allali-Hassani A, Tempel W, Finerty PJ Jr, Mackenzie F, Dimov S, Vedadi M, Park HW
J Biol Chem 2010 May 21;285(21):16330-40. Epub 2010 Mar 18 doi: 10.1074/jbc.M109.039024. PMID: 20299452Free PMC Article
Michel V, Bakovic M
FASEB J 2009 Aug;23(8):2749-58. Epub 2009 Apr 8 doi: 10.1096/fj.08-121491. PMID: 19357133
Ribeiro FM, Alves-Silva J, Volknandt W, Martins-Silva C, Mahmud H, Wilhelm A, Gomez MV, Rylett RJ, Ferguson SS, Prado VF, Prado MA
J Neurochem 2003 Oct;87(1):136-46. PMID: 12969261
Apparsundaram S, Ferguson SM, George AL Jr, Blakely RD
Biochem Biophys Res Commun 2000 Oct 5;276(3):862-7. doi: 10.1006/bbrc.2000.3561. PMID: 11027560

Therapy

Arlauckas SP, Popov AV, Delikatny EJ
Prog Lipid Res 2016 Jul;63:28-40. Epub 2016 Apr 9 doi: 10.1016/j.plipres.2016.03.005. PMID: 27073147Free PMC Article
Qiao D, Nikitina LA, Buznikov GA, Lauder JM, Seidler FJ, Slotkin TA
Environ Health Perspect 2003 Nov;111(14):1730-5. PMID: 14594623Free PMC Article
Cannon JG
Med Res Rev 1994 Sep;14(5):505-31. PMID: 7815851
Vargas HM, Brezenoff HE, Morris HR, Panico M, Etienne A, Challand GS, Holland SM, Alaghband Zadeh J, de Wardener HE
J Cardiovasc Pharmacol 1994 Nov;24(5):773-8. PMID: 7532755
Yoburn BC, Glusman M
Pharmacol Biochem Behav 1984 Jun;20(6):829-33. PMID: 6540444

Prognosis

Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, Wu M, Li M, Daniels JS, Lindsley CW, Hopkins CR, Blakely RD
ACS Chem Neurosci 2015 Mar 18;6(3):417-27. Epub 2015 Feb 2 doi: 10.1021/cn5001809. PMID: 25560927Free PMC Article
Nunes-Freitas AL, Ribeiro-Carvalho A, Lima CS, Dutra-Tavares AC, Manhães AC, Lisboa PC, Oliveira E, Gaspar de Moura E, Filgueiras CC, Abreu-Villaça Y
Toxicol Sci 2011 Sep;123(1):144-54. Epub 2011 Jun 1 doi: 10.1093/toxsci/kfr147. PMID: 21633116
Abreu-Villaça Y, Filgueiras CC, Manhães AC
Behav Brain Res 2011 Aug 10;221(2):367-78. Epub 2010 Jan 6 doi: 10.1016/j.bbr.2009.12.049. PMID: 20060019
Chernyavsky AI, Arredondo J, Karlsson E, Wessler I, Grando SA
J Biol Chem 2005 Nov 25;280(47):39220-8. Epub 2005 Sep 8 doi: 10.1074/jbc.M504407200. PMID: 16150734
Qiao D, Nikitina LA, Buznikov GA, Lauder JM, Seidler FJ, Slotkin TA
Environ Health Perspect 2003 Nov;111(14):1730-5. PMID: 14594623Free PMC Article

Clinical prediction guides

Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, Wu M, Li M, Daniels JS, Lindsley CW, Hopkins CR, Blakely RD
ACS Chem Neurosci 2015 Mar 18;6(3):417-27. Epub 2015 Feb 2 doi: 10.1021/cn5001809. PMID: 25560927Free PMC Article
Serran-Aguilera L, Nuti R, López-Cara LC, Ríos-Marco P, Carrasco MP, Marco C, Entrena A, Macchiarulo A, Hurtado-Guerrero R
Curr Top Med Chem 2014;14(23):2684-93. PMID: 25515750
Pinthong M, Black SA, Ribeiro FM, Pholpramool C, Ferguson SS, Rylett RJ
Mol Pharmacol 2008 Mar;73(3):801-12. Epub 2007 Oct 30 doi: 10.1124/mol.107.040881. PMID: 17971421
Santiago LR, Erickson LC, Hanin I
Neurochem Res 1998 May;23(5):743-50. PMID: 9566614
Santiago LR, Ivy MT, Erickson LC, Hanin I
J Neurosci Methods 1995 Sep-Oct;61(1-2):185-90. PMID: 8618417

Recent systematic reviews

Arlauckas SP, Popov AV, Delikatny EJ
Prog Lipid Res 2016 Jul;63:28-40. Epub 2016 Apr 9 doi: 10.1016/j.plipres.2016.03.005. PMID: 27073147Free PMC Article

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