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Items: 17

1.

Genotoxic Stress

DNA DAMAGE in vivo. [from MeSH]

MedGen UID:
222489
Concept ID:
C1257899
Cell or Molecular Dysfunction
2.

Murine

MedGen UID:
108834
Concept ID:
C0591833
Organic Chemical; Pharmacologic Substance
3.

Methyl Methanesulfonate

An alkylating agent in cancer therapy that may also act as a mutagen by interfering with and causing damage to DNA. [from MeSH]

MedGen UID:
7596
Concept ID:
C0025706
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
4.

DNA damage

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. [from MeSH]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
5.

Able

MedGen UID:
721424
Concept ID:
C1299581
Finding
6.

Separation

MedGen UID:
508125
Concept ID:
C0036679
Pathologic Function
7.

Negative Regulation of G2 to M Transition

G2/M Arrest consists of cellular biochemical mechanisms, responsive to diverse conditions, that control cellular transition from the G2 to M phase of the cell cycle. Cdc2/cycB regulates this transition. During G2, Cdc2 is inactivated by Wee1 and Mt1 kinases. Activation of Cdc25 phosphatase activates Cdc2. If genome damage has occurred, activated DNA-PK/ATM/ATR kinases inactivate Cdc2/cycB by two channels. First, Cdc25 is inactivated by CHK kinases. Second, phosphorylated p53 dissociates from MDM2, is acetylated by p300/PCAF, binds DNA, and activates transcription of genes that inhibit Cdc2/cyclin (14-3-3s, GADD45, and p21Cip1). [from NCI]

MedGen UID:
309180
Concept ID:
C1517345
Molecular Function
8.

Carcinogenesis, Radiation

The study of the processes by which normal cells, exposed to ionizing radiation, are transformed into cancer cells. [from NCI]

MedGen UID:
183091
Concept ID:
C0920372
Neoplastic Process
9.

Stress

Everyone feels stressed from time to time. Not all stress is bad. All animals have a stress response, and it can be life-saving. But chronic stress can cause both physical and mental harm. There are at least three different types of stress:. -Routine stress related to the pressures of work, family, and other daily responsibilities. -Stress brought about by a sudden negative change, such as losing a job, divorce, or illness. -Traumatic stress, which happens when you are in danger of being seriously hurt or killed. Examples include a major accident, war, assault, or a natural disaster. This type of stress can cause post-traumatic stress disorder (PTSD). Different people may feel stress in different ways. Some people experience digestive symptoms. Others may have headaches, sleeplessness, depressed mood, anger, and irritability. People under chronic stress get more frequent and severe viral infections, such as the flu or common cold. Vaccines, such as the flu shot, are less effective for them. Some people cope with stress more effectively than others. It's important to know your limits when it comes to stress, so you can avoid more serious health effects. NIH: National Institute of Mental Health.  [from MedlinePlus]

MedGen UID:
20971
Concept ID:
C0038435
Finding
10.

Intestinal Neoplasm

Tumors or cancer of the INTESTINES. [from MeSH]

MedGen UID:
43932
Concept ID:
C0021841
Neoplastic Process
11.

Disorder of gastrointestinal tract

A non-neoplastic or neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. [from NCI]

MedGen UID:
8970
Concept ID:
C0017178
Disease or Syndrome
12.

Digestive System Neoplasms

new abnormal digestive system tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease; includes neoplasms of any of the organs that are associated with ingestion, digestion, and absorption of food. [from CRISP]

MedGen UID:
8398
Concept ID:
C0012243
Neoplastic Process
13.

Abnormality of the intestine

An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine. [from HPO]

MedGen UID:
7130
Concept ID:
C0021831
Disease or Syndrome
14.

Neoplasm of the gastrointestinal tract

A tumor (abnormal growth of tissue) of the gastrointestinal tract. [from HPO]

MedGen UID:
4846
Concept ID:
C0017185
Neoplastic Process
15.

Neoplasm of the large intestine

Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI. [from MeSH]

MedGen UID:
3171
Concept ID:
C0009404
Neoplastic Process
16.

Colonic Neoplasms

A benign or malignant neoplasm that affects the colon. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colonic adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms. [from NCI]

MedGen UID:
3165
Concept ID:
C0009375
Neoplastic Process
17.

Disorder of colon

Your colon, also known as the large intestine, is part of your digestive system. It's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. Many disorders affect the colon's ability to work properly. Some of these include. -Colorectal cancer . - Colonic polyps - extra tissue growing in the colon that can become cancerous. - Ulcerative colitis - ulcers of the colon and rectum. - Diverticulitis - inflammation or infection of pouches in the colon. - Irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms. Treatment for colonic diseases varies greatly depending on the disease and its severity. Treatment may involve diet, medicines and in some cases, surgery. NIH: National Institute of Diabetes and Digestive and Kidney Diseases.  [from MedlinePlus]

MedGen UID:
1049
Concept ID:
C0009373
Disease or Syndrome
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