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Items: 7

1.

(R)-isomer; corydalis B of tetrahydropalmatine

MedGen UID:
212368
Concept ID:
C0896862
Organic Chemical; Pharmacologic Substance
2.

Limonene, (+)-

An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes. [from NCI]

MedGen UID:
183800
Concept ID:
C0950252
Organic Chemical; Pharmacologic Substance
3.

Limonene

MedGen UID:
72972
Concept ID:
C0064992
Organic Chemical; Pharmacologic Substance
4.

Protein Prenylation

A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol. [from MeSH]

MedGen UID:
57980
Concept ID:
C0162766
Molecular Function
5.

Limonene, (+/-)-

A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes. [from NCI]

MedGen UID:
406483
Concept ID:
C1880232
Organic Chemical; Pharmacologic Substance
6.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
7.

Perillyl Alcohol

A naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle. (NCI04) [from NCI]

MedGen UID:
64721
Concept ID:
C0207661
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
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