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Items: 18

1.

alpha Ketoglutarate

intermediate in the Krebs' cycle; also produced from glutamate in amino group transfer reactions and by oxidative deamination. [from CRISP]

MedGen UID:
220943
Concept ID:
C1291208
Organic Chemical; Pharmacologic Substance
2.

Losartan

An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II. [from MeSH]

MedGen UID:
50933
Concept ID:
C0126174
Organic Chemical; Pharmacologic Substance
3.

Water

H2O, a clear, colorless, odorless, tasteless liquid that freezes into ice below 0 degrees centigrade and boils above 100 degrees centigrade. [from NCI]

MedGen UID:
22697
Concept ID:
C0043047
Inorganic Chemical; Pharmacologic Substance
4.

Hydrochlorothiazide

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. [from MeSH]

MedGen UID:
6942
Concept ID:
C0020261
Organic Chemical; Pharmacologic Substance
5.

Furosemide

a drug used as a diuretic [from CHV]

MedGen UID:
4807
Concept ID:
C0016860
Organic Chemical; Pharmacologic Substance
6.

Choline

a organic chemical substance found in plants and animal organs [from CHV]

MedGen UID:
3048
Concept ID:
C0008405
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
7.

Bumetanide

A sulfamyl diuretic. [from MeSH]

MedGen UID:
2749
Concept ID:
C0006376
Organic Chemical; Pharmacologic Substance
8.

Salicylate

o-hydroxybenzoate. [from CRISP]

MedGen UID:
508105
Concept ID:
C0036075
Organic Chemical; Pharmacologic Substance
9.

Pulmonary arterial hypertension

Pulmonary hypertension is defined mean pulmonary artery pressure of 25mmHg or more and pulmonary capillary wedge pressure of 15mmHg or less when measured by right heart catheterisation at rest and in a supine position. [from HPO]

MedGen UID:
468368
Concept ID:
C3203102
Disease or Syndrome
10.

Primary pulmonary hypertension

Pulmonary arterial hypertension (PAH) is characterized by widespread obstruction and obliteration of the smallest pulmonary arteries. When a sufficient number of vessels are occluded, the resistance to blood flow through the lungs increases, and the right ventricle attempts to compensate by generating higher pressure to maintain pulmonary blood flow. When the right ventricle can no longer compensate for the increased resistance, progressive heart failure ensues. Initial symptoms include dyspnea (60%), fatigue (19%), syncope (8%), chest pain (7%), palpitations (5%), and leg edema (3%). All ages are affected, but the mean age at diagnosis is 36 years. Mean survival after diagnosis is 2.8 years; current therapy does improve clinical function but has modest effect on survival. The term heritable PAH (HPAH) includes familial PAH (PAH that occurs in two or more family members) and simplex PAH (i.e., a single occurrence in a family) when a pathogenic variant has been identified. Most heritable PAH (75%) is caused by a pathogenic variant in BMPR2; pathogenic variants in other genes (i.e., ACVRL1, KCNK3, CAV1, SMAD9, BMPR1B,) are considerably less common (1-3%). HPAH has identical symptoms, signs, and histology as PAH of unknown cause. The time from onset of symptoms to diagnosis may be shorter in individuals with familial PAH, possibly because of familial awareness of the disease. Three retrospective studies suggest that persons with PAH who have a BMPR2 pathogenic variant exhibit more severe disease. [from GeneReviews]

MedGen UID:
57749
Concept ID:
C0152171
Disease or Syndrome
11.

Amino acid

Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
12.

Aminobenzoates

Derivatives of BENZOIC ACID that contain one or more amino groups attached to the benzene ring structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobenzoate structure. [from MeSH]

MedGen UID:
501172
Concept ID:
C3495420
Organic Chemical; Pharmacologic Substance
13.

para-Aminobenzoates

Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure. [from MeSH]

MedGen UID:
473795
Concept ID:
C3266846
Organic Chemical; Pharmacologic Substance
14.

Benzoate

MedGen UID:
67406
Concept ID:
C0220795
Organic Chemical; Pharmacologic Substance
15.

Para-aminohippuric acid

The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [from MeSH]

MedGen UID:
18256
Concept ID:
C0030123
Indicator, Reagent, or Diagnostic Aid; Organic Chemical; Pharmacologic Substance
16.

Furosemide Monosodium Salt

MedGen UID:
168285
Concept ID:
C0887271
Organic Chemical; Pharmacologic Substance
17.

Furosemide Monohydrochloride

MedGen UID:
164560
Concept ID:
C0887272
Organic Chemical; Pharmacologic Substance
18.

Losartan potassium + hydrochlorothiazide

MedGen UID:
473391
Concept ID:
C1302125
Organic Chemical; Pharmacologic Substance
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